scholarly journals S189. PREFRONTAL PARVALBUMIN INTERNEURONS REQUIRE JUVENILE SOCIAL EXPERIENCE TO ESTABLISH ADULT SOCIAL BEHAVIOR

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S110-S110
Author(s):  
Lucy Bicks ◽  
Kazuhiko Yamamuro ◽  
Meghan Flanigan ◽  
Elizabeth Lucas ◽  
Hiroyuki Koike ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Social Behavior ◽  
Psychiatric Disorders ◽  
Social Isolation ◽  
Social Experience ◽  
Designer Drugs ◽  
Social Approach ◽  
Adult Mice ◽  
Behavior Development ◽  
Social Processing

Abstract Background Social isolation during developmental critical windows could be highly detrimental to proper functioning of mature prefrontal cortex (PFC) and establishment of appropriate adult behaviors. However, the specific circuits that undergo social experience-dependent maturation to regulate social behavior development are poorly understood. Social processing is a domain that is commonly dysregulated in psychiatric disorders including Schizophrenia, and is poorly treated by available psychiatric medications. In humans and rodents, portions of the evolutionarily conserved medial prefrontal cortex (mPFC) are part of a network that regulates social behavior. Many disorders with shared social processing deficits show impairments in inhibitory neurotransmission within the brain, particularly in the mPFC, suggesting a role for PFC inhibitory action in regulating social behavior. Parvalbumin expressing interneurons (PVIs) are one of the major subclasses of inhibitory neurons, implicated in psychiatric disorders. Here we aim to examine a contribution of PVIs in mPFC for social behavior development in mice. Methods We use juvenile social isolation (jSI) during a 2-week sensitive window immediately following weaning and test social behavior in adult mice using the 3-chamber test and reciprocal interaction test. To investigate the causal contribution of mPFC-PVIs in social behavior of adult mice, we leveraged chemogenetic technologies. We selectively expressed hM4Di, an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drugs), or hM3Dq an excitatory DREADD in the adult mPFC-PVIs and manipulated mPFC-PVI activity acutely using the selective DREADD agonist, Clozapine-N-oxide (CNO). To test the activity of mPFC-PVIs in response to social experience we used in vivo imaging of calcium transients by fiber photometry. Results We identified a specific activation pattern of parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior to an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are explored by a stimulus mouse. Optogenetic and chemogenetic manipulation revealed that brief dmPFC-PVI activation triggers an active social approach to promote sociability. Juvenile social isolation critically decoupled dmPFC-PVI activation from subsequent active social approach by “freezing” the functional maturation process of dmPFC-PVIs during the juvenile-to-adult transition. Chemogenetic activation of dmPFC-PVI activity in the adult animal mitigated juvenile isolation-induced social deficits. Discussion These results demonstrate that PVI development in the juvenile mPFC is critically linked to long-term impacts on social behavior. Our study implicates mPFC PVIs as promising cellular targets for future therapeutic development on social impairments in psychiatric disorders such as Schizophrenia.

Ibotenic acid induced lesions impair the modulation of dendritic spine plasticity in the prefrontal cortex and amygdala, a phenomenon that underlies working memory and social behavior

2021 ◽  
Vol 896 ◽  
pp. 173883
Author(s):  
Néstor I. Martínez-Torres ◽  
Nallely Vázquez-Hernández ◽  
Fabiola L. Martín-Amaya-Barajas ◽  
Mario Flores-Soto ◽  
Ignacio González-Burgos
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Social Behavior ◽  
Dendritic Spine ◽  
Ibotenic Acid ◽  
Spine Plasticity

Teaching Nonhandicapped Students about Individual Differences: A Pilot Study

1984 ◽  
Vol 9 (3) ◽  
pp. 196-206 ◽  
Author(s):  
William Stainback ◽  
Susan Stainback ◽  
Catherine Hatcher ◽  
Marlene Strathe ◽  
Harriet Healy
Keyword(s):  
Individual Differences ◽  
Pilot Study ◽  
Social Behavior ◽  
Social Interactions ◽  
Social Acceptance ◽  
Empirical Investigation ◽  
Group Setting ◽  
Direct Training ◽  
Behavior Development ◽  
The Social

The lack of social acceptance of handicapped students by their nonhandicapped peers has been cited as a major deterrent to the success of mainstreaming (Strain, 1982). While this problem has been recognized, there has been little empirical investigation of ways to deal with the social acceptance issue beyond direct training of the handicapped in appropriate social behavior development (Gresham 1981). The primary purpose of the present investigation was to examine the influence of training nonhandicapped students about individual differences on their social interactions with rejected handicapped students. The results of the investigation provide initial evidence that training nonhandicapped students about individual differences influences their social interactions with their rejected handicapped peers in a small group setting.

scholarly journals Inhibition of mTOR during a postnatal critical sensitive window rescues deficits in GABAergic PV cell connectivity and social behavior caused by loss of TSC1

2020 ◽  
Author(s):  
Mayukh Choudhury ◽  
Clara A. Amegandjin ◽  
Vidya Jadhav ◽  
Josianne Nunes Carriço ◽  
Ariane Quintal ◽  
...  
Keyword(s):  
Social Behavior ◽  
Time Course ◽  
Cell Types ◽  
Developmental Time ◽  
Adult Mice ◽  
Mtorc1 Signaling ◽  
Pv Cell ◽  
Mechanistic Basis

ABSTRACTMutations in regulators of the Mechanistic Target Of Rapamycin Complex 1 (mTORC1), such as Tsc1/2, lead to neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. Whereas the effects of mTORC1 signaling dysfunction within diverse cell types are likely critical for the onset of the diverse neurological symptoms associated with mutations in mTORC1 regulators, they are not well understood. In particular, the effects of mTORC1 dys-regulation in specific types of inhibitory interneurons are unclear.Here, we showed that Tsc1 haploinsufficiency in parvalbumin (PV)-positive GABAergic interneurons either in cortical organotypic cultures or in vivo caused a premature increase in their perisomatic innervations, followed by a striking loss in adult mice. This effects were accompanied by alterations of AMPK-dependent autophagy in pre-adolescent but not adult mice. PV cell-restricted Tsc1 mutant mice showed deficits in social behavior. Treatment with the mTOR inhibitor Rapamycin restricted to the third postnatal week was sufficient to permanently rescue deficits in both PV cell innervation and social behavior in adult conditional haploinsufficient mice. All together, these findings identify a novel role of Tsc1-mTORC1 signaling in the regulation of the developmental time course and maintenance of cortical PV cell connectivity and provide a mechanistic basis for the targeted rescue of autism-related behaviors in disorders associated with deregulated mTORC1 signaling.

scholarly journals Combined social and spatial coding in a descending projection from the prefrontal cortex

2017 ◽  
Author(s):  
M. Murugan ◽  
M. Park ◽  
J. Taliaferro ◽  
H.J. Jang ◽  
J. Cox ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Social Behavior ◽  
Spatial Information ◽  
Spatial Association ◽  
Well Being ◽  
Unique Contribution ◽  
Social Investigation ◽  
Spatial Coding ◽  
Socially Motivated ◽  
Spatial Locations

Social interactions are crucial to the survival and well-being of all mammals, including humans. Although the prelimbic cortex (PL, part of medial prefrontal cortex) has been implicated in social behavior, it is not clear which neurons are relevant, nor how they contribute. We found that the PL contains anatomically and molecularly distinct subpopulations of neurons that target 3 downstream regions that have been implicated in social behavior: the nucleus accumbens (NAc), the amygdala, and the ventral tegmental area. Activation of NAc-projecting PL neurons (PL-NAc), but not the other subpopulations, decreased preference for a social target, suggesting an unique contribution of this population to social behavior. To determine what information PL-NAc neurons convey, we recorded selectively from them, and found that individual neurons were active during social investigation, but only in specific spatial locations. Spatially-specific inhibition of these neurons prevented the formation of a social-spatial association at the inhibited location. In contrast, spatially nonspecific inhibition did not affect social behavior. Thus, the unexpected combination of social and spatial information within the PL-NAc population appears to support socially motivated behavior by enabling the formation of social-spatial associations.

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