Faculty Opinions recommendation of Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior.

For many, the terms oxytocin and vasopressin immediately evoke images of animals interacting with one another, as both of these neuropeptides have been implicated as being part of the neurochemical “glue” that socially binds animals. However, social environments and social interactions are complex and include behaviors that bring animals together as well as behaviors that keep animals apart. It is at the intersection of social context, social experience, and an individual’s sex that oxytocin and vasopressin act to modulate social behavior and social cognition. In this review, this complexity will be explored across mammalian species, with a focus on social memory, cooperative behaviors, and competitive behaviors. Implications for humans as well as future directions will also be considered.

Download Full-text

Pro-social behavior in rats is modulated by social experience

eLife ◽

10.7554/elife.01385 ◽

2014 ◽

Vol 3 ◽

Cited By ~ 105

Author(s):

Inbal Ben-Ami Bartal ◽

David A Rodgers ◽

Maria Sol Bernardez Sarria ◽

Jean Decety ◽

Peggy Mason

Keyword(s):

Social Behavior ◽

Genetic Relatedness ◽

Social Motivation ◽

Social Experience ◽

Pro Social Behavior

In mammals, helping is preferentially provided to members of one’s own group. Yet, it remains unclear how social experience shapes pro-social motivation. We found that rats helped trapped strangers by releasing them from a restrainer, just as they did cagemates. However, rats did not help strangers of a different strain, unless previously housed with the trapped rat. Moreover, pair-housing with one rat of a different strain prompted rats to help strangers of that strain, evidence that rats expand pro-social motivation from one individual to phenotypically similar others. To test if genetic relatedness alone can motivate helping, rats were fostered from birth with another strain and were not exposed to their own strain. As adults, fostered rats helped strangers of the fostering strain but not rats of their own strain. Thus, strain familiarity, even to one’s own strain, is required for the expression of pro-social behavior.

Download Full-text

Social Experience Interacts with Serotonin to Affect Functional Connectivity in the Social Behavior Network following Playback of Social Vocalizations in Mice

eNeuro ◽

10.1523/eneuro.0247-20.2021 ◽

2021 ◽

Vol 8 (2) ◽

pp. ENEURO.0247-20.2021

Author(s):

Christopher L. Petersen ◽

Sarah E. D. Davis ◽

Bhumi Patel ◽

Laura M. Hurley

Keyword(s):

Social Behavior ◽

Functional Connectivity ◽

Social Experience ◽

The Social ◽

Behavior Network

Download Full-text

The Relationship Between Social Behavior and the Use of Space in the Benthic Fish Chasmodes Bosquianus Lacepede (Teleostei, Blenniidae)

Behaviour ◽

10.1163/156853974x00525 ◽

1974 ◽

Vol 49 (3-4) ◽

pp. 205-225 ◽

Cited By ~ 5

Author(s):

R.R. Phillips

Keyword(s):

Social Behavior ◽

Factorial Design ◽

Social Experience ◽

The Other ◽

Physical Contact ◽

Benthic Fish ◽

Social Encounters ◽

The Relationship ◽

Prior Residency ◽

Observation Period

AbstractI. The purpose of this study was to determine whether male blennies are attracted to or repulsed by neighboring prior residents. In a previous study of prior residency, I found that the newcomer often was physically attacked and chased. This obscured the question of whether the newcomer initially was attracted to the resident. In the present study, the two animals were separated by a transparent, perforated barrier so that physical contact was impossible. The newcomer could choose between approaching the resident and utilizing the enclosure within his view or withdrawing and using an enclosure out of sight of the resident. 2. A second variable, that of the effect of prior social experience, was also tested. The newcomers were separated into two classes depending on whether they dominated or were subordinate in previous social encounters. The effects of these two variables were separated by means of a 2 X 2 factorial design. Four measures of approach/ withdrawal to the prior resident and three measures of enclosure choice were employed. 3. Those newcomers that had dominated in previous encounters approached the prior resident. They did not demonstrate a preference for either of the enclosures during the observation period (30 minutes). A measure covering a longer period did reveal a preference for the enclosure near the resident. 4. The subordinate fish neither approached nor avoided the resident. They did use the enclosure farther away from the prior resident more than they used the other enclosure, hower.

Download Full-text

Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males

Neuroscience Letters ◽

10.1016/j.neulet.2014.02.023 ◽

2014 ◽

Vol 566 ◽

pp. 131-136 ◽

Cited By ~ 53

Author(s):

Freedom H. Holland ◽

Prabarna Ganguly ◽

David N. Potter ◽

Elena H. Chartoff ◽

Heather C. Brenhouse

Keyword(s):

Prefrontal Cortex ◽

Social Behavior ◽

Life Stress ◽

Early Life ◽

Early Life Stress ◽

Parvalbumin Interneurons ◽

Time Point

Download Full-text

S189. PREFRONTAL PARVALBUMIN INTERNEURONS REQUIRE JUVENILE SOCIAL EXPERIENCE TO ESTABLISH ADULT SOCIAL BEHAVIOR

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa031.255 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S110-S110

Author(s):

Lucy Bicks ◽

Kazuhiko Yamamuro ◽

Meghan Flanigan ◽

Elizabeth Lucas ◽

Hiroyuki Koike ◽

...

Keyword(s):

Prefrontal Cortex ◽

Social Behavior ◽

Psychiatric Disorders ◽

Social Isolation ◽

Social Experience ◽

Designer Drugs ◽

Social Approach ◽

Adult Mice ◽

Behavior Development ◽

Social Processing

Abstract Background Social isolation during developmental critical windows could be highly detrimental to proper functioning of mature prefrontal cortex (PFC) and establishment of appropriate adult behaviors. However, the specific circuits that undergo social experience-dependent maturation to regulate social behavior development are poorly understood. Social processing is a domain that is commonly dysregulated in psychiatric disorders including Schizophrenia, and is poorly treated by available psychiatric medications. In humans and rodents, portions of the evolutionarily conserved medial prefrontal cortex (mPFC) are part of a network that regulates social behavior. Many disorders with shared social processing deficits show impairments in inhibitory neurotransmission within the brain, particularly in the mPFC, suggesting a role for PFC inhibitory action in regulating social behavior. Parvalbumin expressing interneurons (PVIs) are one of the major subclasses of inhibitory neurons, implicated in psychiatric disorders. Here we aim to examine a contribution of PVIs in mPFC for social behavior development in mice. Methods We use juvenile social isolation (jSI) during a 2-week sensitive window immediately following weaning and test social behavior in adult mice using the 3-chamber test and reciprocal interaction test. To investigate the causal contribution of mPFC-PVIs in social behavior of adult mice, we leveraged chemogenetic technologies. We selectively expressed hM4Di, an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drugs), or hM3Dq an excitatory DREADD in the adult mPFC-PVIs and manipulated mPFC-PVI activity acutely using the selective DREADD agonist, Clozapine-N-oxide (CNO). To test the activity of mPFC-PVIs in response to social experience we used in vivo imaging of calcium transients by fiber photometry. Results We identified a specific activation pattern of parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior to an active bout, or a bout initiated by the focal mouse, but not during a passive bout when mice are explored by a stimulus mouse. Optogenetic and chemogenetic manipulation revealed that brief dmPFC-PVI activation triggers an active social approach to promote sociability. Juvenile social isolation critically decoupled dmPFC-PVI activation from subsequent active social approach by “freezing” the functional maturation process of dmPFC-PVIs during the juvenile-to-adult transition. Chemogenetic activation of dmPFC-PVI activity in the adult animal mitigated juvenile isolation-induced social deficits. Discussion These results demonstrate that PVI development in the juvenile mPFC is critically linked to long-term impacts on social behavior. Our study implicates mPFC PVIs as promising cellular targets for future therapeutic development on social impairments in psychiatric disorders such as Schizophrenia.

Download Full-text