scholarly journals 0672 The Effect Of Armodafinil On Sleep Spindles In Obstructive Sleep Apnea: Secondary Analysis Of A Randomized Placebo-controlled Trial

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A256-A257
Author(s):  
L Emami ◽  
N S Marshall ◽  
J L Chapman ◽  
G Cho ◽  
R R Grunstein ◽  
...  
Keyword(s):  
Driving Simulator ◽  
Research Training ◽  
Controlled Trial ◽  
Nrem Sleep ◽  
Driving Performance ◽  
Sleep Spindles ◽  
Time On Task ◽  
Sleep Spindle ◽  
Simulated Driving ◽  
Obstructive Sleep

Abstract Introduction Armodafinil has been trialed in OSA patients to promote wakefulness and simulated driving performance. We have previously completed a 6-month trial of 150mg of armodafinil vs placebo in moderate-severe OSA patients not using CPAP (ACTRN# 12611000847910) observing that participants on armodafinil learned to perform better across a 90-minute driving simulator task faster than those on placebo. It is possible that this reduction in time-on-task decrement may have been due to increased learning on armodafinil. Sleep spindles have previously been implicated in procedural learning and neurobehavioral performance. We hypothesized that armodafinil increases sleep spindle events during NREM sleep to enhance learning. Methods Sixty-three overweight severe OSA patients (mean BMI: 32.3kg/m2 (26.1-42.5); age 53.1 years (28-71), 52 males) underwent overnight in-lab polysomnography at baseline (0 months) and at a 6-month follow-up. All-night EEG signals were analyzed using a previously validated automated spindle detection algorithm. EEG recordings were visually inspected by an experienced sleep physician (LE), who was blinded to drug allocation. To minimize the likelihood of type 1 error we selected three key spindle variables detected at Cz for analysis of change between 0 and 6 months: 1) total number of spindle events (11-16 Hz) in NREM sleep 2) density of slow spindles (≥11 to ≤ 13Hz) per minute of NREM sleep, and 3) fast spindle density in NREM (>13 to ≤ 16Hz). Results The change in total spindle count in NREM sleep (armodafinil=11.6 vs Placebo =-17.1, p=0.57), fast spindle density (armodafinil=0.06 vs Placebo =-0.02, p=0.63) and slow spindle density (armodafinil=-0.00 vs. Placebo =-0.03, p=0.74) were not increased by armodafinil. Conclusion If armodafinil enhances simulated driving performance in a way that suppresses time-on-task effects it does not appear to be through a sleep spindle enhancing mechanism. Armodafinil is probably not a pharmacological method of enhancing sleep spindles. Support World Sleep Society (International Sleep Research Training Program)CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney

scholarly journals P018 The effects of zopiclone on sleep spindles in obstructive sleep apnea: A randomized placebo-controlled trial

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A27-A27
Author(s):  
S Carter ◽  
J Siong ◽  
C Hoyos ◽  
J Carberry ◽  
R Grunstein ◽  
...  
Keyword(s):  
Driving Simulator ◽  
Standard Dose ◽  
Controlled Trial ◽  
Driving Performance ◽  
Sleep Spindles ◽  
Sleep Spindle ◽  
Double Blind ◽  
Simulated Driving ◽  
Spindle Activity ◽  
Obstructive Sleep

Abstract Purpose This study aimed to determine the effects of a standard dose of zopiclone (7.5mg) on sleep spindle activity and to assess if potential changes in sleep spindles correlate with improvements in next-day measures of sleepiness and simulated driving performance in people with obstructive sleep apnoea (OSA). Methods Thirty-one people with OSA completed polysomnography (PSG) at baseline followed by 1-month nightly treatment with 7.5mg zopiclone or placebo according to a double-blind, parallel design (ANZCTRN12613001106729). Participants completed two further PSGs on the first (night1) and final (night30) night of treatment. A 30-min AusEd driving simulator task and a subjective sleepiness questionnaire (Karolinska sleepiness scale, KSS) on each visit were also performed in the morning. Sleep spindle events and spindle frequency activity (SFA, sigma EEG power) were quantified during N2 sleep from all-night EEG recordings. Results Sleep spindle events were consistently higher in both frontal and central EEG sites on night1 and night30 treatment nights in the zopiclone group compared to placebo (e.g. F4 night30 = 346[SEM±28] vs. 239[SEM±27] total # of sleep spindles respectively, p=0.009). Additionally, greater sleep spindle density in the zopiclone group correlated with better next-day simulated driving performance on night1 and night30. No correlations were observed between sleep spindle activity and the KSS. Conclusions Zopiclone is associated with greater sleep spindle activity in OSA compared to placebo, and sleep spindle increases are associated with better driving simulator performance. Thus, hypnotic-induced increases in sleep spindles may help alleviate certain cognitive performance decrements in people with OSA.

Effects of Individual Differences, Attention, and Memory Deficits on Driver Distraction

2020 ◽  
Vol 64 (1) ◽  
pp. 1196-1201
Author(s):  
Alejandro A. Arca ◽  
Kaitlin M. Stanford ◽  
Mustapha Mouloua
Keyword(s):  
Individual Differences ◽  
Driving Simulator ◽  
Memory Deficits ◽  
Driving Performance ◽  
Driver Distraction ◽  
Phone Call ◽  
Traffic Density ◽  
Attention And Memory ◽  
Adhd Diagnosis ◽  
Simulated Driving

The current study was designed to empirically examine the effects of individual differences in attention and memory deficits on driver distraction. Forty-eight participants consisting of 37 non-ADHD and 11 ADHD drivers were tested in a medium fidelity GE-ISIM driving simulator. All participants took part in a series of simulated driving scenarios involving both high and low traffic conditions in conjunction with completing a 20-Questions task either by text- message or phone-call. Measures of UFOV, simulated driving, heart rate variability, and subjective (NASA TLX) workload performance were recorded for each of the experimental tasks. It was hypothesized that ADHD diagnosis, type of cellular distraction, and traffic density would affect driving performance as measured by driving performance, workload assessment, and physiological measures. Preliminary results indicated that ADHD diagnosis, type of cellular distraction, and traffic density affected the performance of the secondary task. These results provide further evidence for the deleterious effects of cellphone use on driver distraction, especially for drivers who are diagnosed with attention-deficit and memory capacity deficits. Theoretical and practical implications are discussed, and directions for future research are also presented.

scholarly journals Impact of Age-Related Vision Changes on Driving

2020 ◽  
Vol 17 (20) ◽  
pp. 7416
Author(s):  
Sonia Ortiz-Peregrina ◽  
Carolina Ortiz ◽  
Miriam Casares-López ◽  
José J. Castro-Torres ◽  
Luis Jiménez del Barco ◽  
...  
Keyword(s):  
Linear Regression ◽  
Visual Function ◽  
Driving Simulator ◽  
Multiple Linear Regression Model ◽  
Driving Performance ◽  
Older Drivers ◽  
Linear Regression Models ◽  
Simulated Driving ◽  
Age Related ◽  
Intraocular Straylight

Aging leads to impaired visual function, which can affect driving—a very visually demanding task—and has a direct impact on an individual’s quality of life if their license is withdrawn. This study examined the associations between age-related vision changes and simulated driving performance. To this end, we attempted to determine the most significant visual parameters in terms of evaluating elderly drivers’ eyesight. Twenty-one younger drivers (aged 25–40) were compared to 21 older drivers (aged 56–71). Study participants were assessed for visual acuity, contrast sensitivity, halos, and intraocular straylight, which causes veiling luminance on the retina and degrades vision. Driving performance was evaluated using a driving simulator. The relationships between simulated driving performance and the visual parameters tested were examined with correlation analyses and linear regression models. Older drivers presented impairment in most visual parameters (p < 0.05), with straylight being the most significantly affected (we also measured the associated effect size). Older drivers performed significantly worse (p < 0.05) in the simulator test, with a markedly lower performance in lane stability. The results of the multiple linear regression model evidenced that intraocular straylight is the best visual parameter for predicting simulated driving performance (R2 = 0.513). Older drivers have shown significantly poorer results in several aspects of visual function, as well as difficulties in driving simulator performance. Our results suggest that the non-standardized straylight evaluation could be significant in driver assessments, especially at the onset of age-related vision changes.

scholarly journals CPAP Treatment Partly Normalizes Sleep Spindle Features in Obstructive Sleep Apnea

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Tiia Saunamäki ◽  
Eero Huupponen ◽  
Juho Loponen ◽  
Sari-Leena Himanen
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Control Group ◽  
Sleep Spindles ◽  
Sleep Spindle ◽  
Cpap Treatment ◽  
Automated Method ◽  
Obstructive Sleep

Objective. Obstructive sleep apnea (OSA) decreases sleep spindle density and frequency. We evaluated the effects of continuous positive airway pressure (CPAP) treatment on different features of sleep spindles.Methods. Twenty OSA patients underwent two night polysomnographies in a diagnostic phase and one night polysomnography after 6 months of CPAP treatment. The control group comprised 20 healthy controls. Sleep spindles were analyzed by a previously developed automated method. Unilateral and bilateral spindles were identified in central and frontopolar brain locations. Spindle density and frequency were determined for the first and last half of the NREM time.Results. The density of bilateral central spindles, which did not change in the untreated OSA patients, increased towards the morning hours during CPAP treatment and in the controls. Central spindles did not become faster with sleep in OSA patients and the central spindles remained slow in the left hemisphere even with CPAP.Conclusion. CPAP treatment normalized spindle features only partially. The changes may be associated with deficits in thalamocortical spindle generating loops.Significance. This study shows that some sleep spindle changes persist after CPAP treatment in OSA patients. The association of these changes to daytime symptoms in OSA patients needs to be further evaluated.

scholarly journals P143 Sleep-dependent declarative memory consolidation and NREM sleep EEG oscillations in older adults with obstructive sleep apnea

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A68-A68
Author(s):  
J Teh ◽  
L Grummit ◽  
C Haroutonian ◽  
N Cross ◽  
D Bartlett ◽  
...  
Keyword(s):  
Older Adults ◽  
Memory Consolidation ◽  
Declarative Memory ◽  
Memory Task ◽  
Nrem Sleep ◽  
Sleep Eeg ◽  
Control Group ◽  
Sleep Spindles ◽  
Targeted Interventions ◽  
Obstructive Sleep

Abstract Objectives To compare overnight declarative memory consolidation and NREM sleep EEG oscillations in older adults with OSA to an age-matched control group, and to assess the quantitative sleep EEG features as correlates of memory consolidation. Methods 46 participants (24 without OSA and 22 patients with OSA) were recruited. Participants completed a word-paired associates declarative memory task before and after an 8-hour sleep opportunity with full polysomnography. Power spectral analysis was performed on all-night EEG recorded at frontal and central electrode sites. We calculated slow wave activity (slow oscillations absolute power 0.25–1 Hz; and delta EEG power (0.5–4.5 Hz) in NREM sleep. Slow spindle density (11–13 Hz, events p/min) and fast spindle density (13–16 Hz, events p/min) in stage N2 was derived using an automated spindle detection algorithm. Results Patients with OSA showed no significant differences in overnight memory recall and recognition compared to individuals without OSA. The OSA group showed reduced slow spindle density at the central region and fast spindle density at the frontal region relative to controls. No differences were observed in SWA. Within group correlations showed slow and fast spindle density were correlated to percent recognition in the control group. Conclusion Older adults with OSA had deficits in slow and fast sleep spindles compared to controls. OSA patients showed preserved sleep-dependent declarative memory consolidation despite sleep fragmentation and intermittent hypoxemia. Sleep spindles were positively correlated with overnight memory consolidation in controls but not OSA patients. Targeted interventions to boost spindles may enhance memory consolidation in older adults.

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