scholarly journals Altered circadian activity and sleep/wake rhythms in the stable tubule only polypeptide (STOP) null mouse model of schizophrenia

SLEEP ◽  
2020 ◽  
Author(s):  
Samuel Deurveilher ◽  
Kristin Robin Ko ◽  
Brock St C Saumure ◽  
George S Robertson ◽  
Benjamin Rusak ◽  
...  
Keyword(s):  
Wheel Running ◽  
Active Phase ◽  
Null Mouse ◽  
Wild Type ◽  
Activity Rhythms ◽  
Lighting Conditions ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Lower Amplitude ◽  
Free Running

Abstract Sleep and circadian rhythm disruptions commonly occur in individuals with schizophrenia. Stable tubule only polypeptide (STOP) knockout (KO) mice show behavioral impairments resembling symptoms of schizophrenia. We previously reported that STOP KO mice slept less and had more fragmented sleep and waking than wild-type littermates under a light/dark (LD) cycle. Here, we assessed the circadian phenotype of male STOP KO mice by examining wheel-running activity rhythms and EEG/EMG-defined sleep/wake states under both LD and constant darkness (DD) conditions. Wheel-running activity rhythms in KO and wild-type mice were similarly entrained in LD, and had similar free-running periods in DD. The phase delay shift in response to a light pulse given early in the active phase under DD was preserved in KO mice. KO mice had markedly lower activity levels, lower amplitude activity rhythms, less stable activity onsets, and more fragmented activity than wild-type mice in both lighting conditions. KO mice also spent more time awake and less time in rapid eye movement sleep (REMS) and non-REMS (NREMS) in both LD and DD conditions, with the decrease in NREMS concentrated in the active phase. KO mice also showed altered EEG features and higher amplitude rhythms in wake and NREMS (but not REMS) amounts in both lighting conditions, with a longer free-running period in DD, compared to wild-type mice. These results indicate that the STOP null mutation in mice altered the regulation of sleep/wake physiology and activity rhythm expression, but did not grossly disrupt circadian mechanisms.

Restricted feeding entrains circadian wheel-running activity rhythms of the kowari

1991 ◽  
Vol 261 (4) ◽  
pp. R819-R827 ◽  
Author(s):  
G. A. Kennedy ◽  
G. J. Coleman ◽  
S. M. Armstrong
Keyword(s):  
Pilot Study ◽  
Wheel Running ◽  
Light Period ◽  
Restricted Feeding ◽  
Activity Rhythms ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Free Running ◽  
Anticipatory Activity ◽  
Constant Dark

The effect of daily restricted feeding (RF) on the circadian wheel-running rhythms of the kowari, Dasyuroides byrnei, was examined in two experiments. Kowaris were presented with a preferred food (determined in a pilot study) during a daily 2-h meal in the light period of a 14:10 light-dark (LD) cycle (expts 1 and 2), during constant dark (DD) immediately after termination of the LD cycle (expt 1), and during DD when kowaris were free running (expt 1). Results showed that 1) RF elicited anticipatory activity similar in duration and phasing to that observed in the rat; 2) cycles of meal-associated activity free ran for up to 6 days after the termination of RF; 3) activity persists at a phase near that of the former mealtime during periods of food deprivation; and 4) activity indicative of beating between two pacemakers occurred when feeding was restricted to the L period of LD cycles. Together these observations suggest that the activity rhythms of the kowari may be controlled by separate, but possibly coupled, light-entrainable and food-entrainable pacemakers, as are those of the rat.

scholarly journals SCN lesions abolish ultradian and circadian components of activity rhythms in LEW/Ztm rats

1989 ◽  
Vol 256 (5) ◽  
pp. R1027-R1039 ◽  
Author(s):  
F. Wollnik ◽  
F. W. Turek
Keyword(s):  
Activity Pattern ◽  
Wheel Running ◽  
Dark Cycle ◽  
Spectral Estimates ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Neural Substrate ◽  
Free Running ◽  
Males And Females ◽  
Periodogram Analysis

A trimodal locomotor activity pattern has been observed in LEW/Ztm rats. Complete and partial lesions of the suprachiasmatic nucleus (SCN) were used to determine whether the same neural substrate may underlie the circadian rhythms and the ultradian modulation of wheel-running activity in these rats. Whereas sham lesions had little or no effect on the wheel-running activity pattern, complete SCN lesions resulted in a complete loss of circadian and ultradian activity components under free-running or 12:12 h light-dark cycle (12:12 LD) conditions. Ultradian and circadian activity components were still present after partial SCN lesions. Periodogram analysis for any given animal revealed that the ultradian periods were always submultiples of the entrained or free-running circadian period. Furthermore there was a high correlation between the amplitudes of circadian and ultradian spectral estimates, but with a different slope in males and females. These results indicate that in LEW/Ztm rats the SCN contributes to the control of both the circadian wheel-running rhythm and the trimodal ultradian modulation of that behavior.

Failure of pinealectomy or melatonin to alter circadian activity rhythm of the rat

1982 ◽  
Vol 242 (3) ◽  
pp. R261-R264 ◽  
Author(s):  
P. W. Cheung ◽  
C. E. McCormack
Keyword(s):  
Wheel Running ◽  
Activity Rhythm ◽  
Physiological Mechanism ◽  
Continuous Darkness ◽  
Running Activity ◽  
Melatonin Administration ◽  
Wheel Running Activity ◽  
Free Running ◽  
Dim Light ◽  
Free Running Period

These experiments were undertaken to determine if the pineal gland is involved in the physiological mechanism by which the rat alters its free-running period (tau) in response to changes in illuminance. Spontaneous wheel-running activity was recorded from pinealectomized or sham-operated female Charles River rats. The tau of running activity was determined in continuous darkness (DD) or in continuous dim light (LL). Pinealectomized rats and sham-operated rats lengthened their tau's to approximately the same extent when shifted from DD to LL and shortened their tau's when shifted back to DD. Continuous melatonin administration via Silastic capsules failed to alter tau of rats kept in dim LL. These results indicate that the pineal is not primarily involved in the mechanism by which the rat alters tau in response to changes in illuminance.

Stability of circadian timing with age in Syrian hamsters

1998 ◽  
Vol 275 (4) ◽  
pp. R960-R968 ◽  
Author(s):  
Fred C. Davis ◽  
N. Viswanathan
Keyword(s):  
Wheel Running ◽  
Activity Level ◽  
Circadian Pacemaker ◽  
Experimental Conditions ◽  
Syrian Hamsters ◽  
Running Activity ◽  
Age Related ◽  
Wheel Running Activity ◽  
Free Running ◽  
Free Running Period

The causes of age-related disruptions in the timing of human sleep and wakefulness are not known but may include changes in both the homeostatic and circadian regulation of sleep. In Syrian hamsters the free running period of the circadian activity/rest rhythm has been reported to shorten with age. Although this has been observed under a variety of experimental conditions, the changes have been small and their consistency uncertain. In the present study, the wheel running activity/rest rhythm was continuously measured in male Syrian hamsters ( Mesocricetus auratus) in dim constant light (<1 lx) from 8 wk of age until death. Fifteen hamsters survived to at least 90 wk (28%). The average free running period of these hamsters did not change with age. In 18 hamsters that died between 50 and 88 wk, free running period also did not change before death. In contrast to free running period, other measures related to activity level changed significantly with age and before death. Despite changes in the expression of the activity/rest rhythm, the free running period of the hamster circadian pacemaker remained remarkably stable with age.

Circadian wheel running activity rhythms in two strains of domestic rabbit

1994 ◽  
Vol 55 (2) ◽  
pp. 385-389 ◽  
Author(s):  
Gerard A Kennedy ◽  
Robyn Hudson ◽  
Stuart Maxwell Armstrong
Keyword(s):  
Wheel Running ◽  
Activity Rhythms ◽  
Domestic Rabbit ◽  
Running Activity ◽  
Wheel Running Activity

Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORβ knockout

2007 ◽  
Vol 292 (6) ◽  
pp. R2357-R2367 ◽  
Author(s):  
Monica I. Masana ◽  
Isabel C. Sumaya ◽  
Michael Becker-Andre ◽  
Margarita L. Dubocovich
Keyword(s):  
Circadian Rhythms ◽  
Light Pulse ◽  
Learned Helplessness ◽  
Wheel Running ◽  
Receptor Gene ◽  
Activity Rhythms ◽  
Pineal Melatonin ◽  
Running Activity ◽  
Melatonin Administration ◽  
Wheel Running Activity

This study reports for the first time the effects of retinoid-related orphan receptors [RORβ; receptor gene deletion RORβ(C3H)−/−] in C3H/HeN mice on behavioral and circadian phenotypes. Pineal melatonin levels showed a robust diurnal rhythm with high levels at night in wild-type (+/+), heterozygous (+/−), and knockout (−/−) mice. The RORβ(C3H)−/− mice displayed motor (“duck gait,” hind paw clasping reflex) and olfactory deficits, and reduced anxiety and learned helplessness-related behaviors. Circadian rhythms of wheel-running activity in all genotypes showed entrainment to the light-dark (LD) cycle, and free running in constant dark, with RORβ(C3H)−/− mice showing a significant increase in circadian period ( tau). Melatonin administration (90 μg/mouse sc for 3 days) at circadian time (CT) 10 induced phase advances, while exposure to a light pulse (300 lux) at CT 14 induced phase delays of circadian activity rhythms of the same magnitude in all genotypes. In RORβ(C3H)−/− mice a light pulse at CT 22 elicited a larger phase advance in activity rhythms and a slower rate of reentrainment after a 6-h advance in the LD cycle compared with (+/+) mice. Yet, the rate of reentrainment was significantly advanced by melatonin administration at the new dark onset in both (+/+) and (−/−) mice. We conclude that the RORβ nuclear receptor is not involved in either the rhythmic production of pineal melatonin or in mediating phase shifts of circadian rhythms by melatonin, but it may regulate clock responses to photic stimuli at certain time domains.

Sign in / Sign up

Export Citation Format

Share Document