scholarly journals 0112 Sleep-Dependent Motor Sequence Memory Consolidation in Individuals with Periodic Limb Movements

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A44-A44
Author(s):  
L B Ray ◽  
V Sergeeva ◽  
J Viczko ◽  
A M Owen ◽  
S M Fogel
Keyword(s):  
Memory Consolidation ◽  
Periodic Limb Movements ◽  
Motor Sequence ◽  
Limb Movements ◽  
Sequence Memory

Sleep-dependent motor sequence memory consolidation in individuals with periodic limb movements

2017 ◽  
Vol 40 ◽  
pp. e276
Author(s):  
L.B. Ray ◽  
V. Sergeeva ◽  
J. Viczko ◽  
A.M. Owen ◽  
S.M. Fogel
Keyword(s):  
Memory Consolidation ◽  
Periodic Limb Movements ◽  
Motor Sequence ◽  
Limb Movements ◽  
Sequence Memory

Sleep-dependent motor sequence memory consolidation in individuals with periodic limb movements

2017 ◽  
Vol 40 ◽  
pp. 23-32 ◽  
Author(s):  
Valya Sergeeva ◽  
Jeremy Viczko ◽  
Laura B. Ray ◽  
Adrian M. Owen ◽  
Stuart M. Fogel
Keyword(s):  
Memory Consolidation ◽  
Periodic Limb Movements ◽  
Motor Sequence ◽  
Limb Movements ◽  
Sequence Memory

Sleep Increases Amplitude of Mu-Beta Oscillations during Motor Sequence Memory Consolidation

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S55
Author(s):  
G. Albouy ◽  
F. Lecaignard ◽  
C. Delpuech ◽  
P.E. Aguera ◽  
P.H. Luppi ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Motor Sequence ◽  
Beta Oscillations ◽  
Sequence Memory

scholarly journals Distributed slow-wave dynamics during sleep predict memory consolidation and its impairment in schizophrenia

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Ullrich Bartsch ◽  
Andrew J. Simpkin ◽  
Charmaine Demanuele ◽  
Erin Wamsley ◽  
Hugh M. Marston ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Partial Least Squares Regression ◽  
Nrem Sleep ◽  
Network Activity ◽  
Healthy Controls ◽  
Least Squares Regression ◽  
Motor Sequence ◽  
Wave Dynamics ◽  
Sequence Memory ◽  
Phase Amplitude

Abstract The slow waves (SW) of non-rapid eye movement (NREM) sleep reflect neocortical components of network activity during sleep-dependent information processing; their disruption may therefore impair memory consolidation. Here, we quantify sleep-dependent consolidation of motor sequence memory, alongside sleep EEG-derived SW properties and synchronisation, and SW–spindle coupling in 21 patients suffering from schizophrenia and 19 healthy volunteers. Impaired memory consolidation in patients culminated in an overnight improvement in motor sequence task performance of only 1.6%, compared with 15% in controls. During sleep after learning, SW amplitudes and densities were comparable in healthy controls and patients. However, healthy controls showed a significant 45% increase in frontal-to-occipital SW coherence during sleep after motor learning in comparison with a baseline night (baseline: 0.22 ± 0.05, learning: 0.32 ± 0.05); patient EEG failed to show this increase (baseline: 0.22 ± 0.04, learning: 0.19 ± 0.04). The experience-dependent nesting of spindles in SW was similarly disrupted in patients: frontal-to-occipital SW–spindle phase-amplitude coupling (PAC) significantly increased after learning in healthy controls (modulation index baseline: 0.17 ± 0.02, learning: 0.22 ± 0.02) but not in patients (baseline: 0.13 ± 0.02, learning: 0.14 ± 0.02). Partial least-squares regression modelling of coherence and PAC data from all electrode pairs confirmed distributed SW coherence and SW–spindle coordination as superior predictors of overnight memory consolidation in healthy controls but not in patients. Quantifying the full repertoire of NREM EEG oscillations and their long-range covariance therefore presents learning-dependent changes in distributed SW and spindle coordination as fingerprints of impaired cognition in schizophrenia.

scholarly journals Neurophysiological predictors of memory impairment in schizophrenia: decoupled slow-wave dynamics during non-REM sleep

2019 ◽  
Author(s):  
Ullrich Bartsch ◽  
Andrew Simpkin ◽  
Charmaine Demanuele ◽  
Erin Wamsley ◽  
Hugh Marston ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Long Range ◽  
Memory Consolidation ◽  
Network Activity ◽  
Rapid Eye Movement Sleep ◽  
Least Squares Regression ◽  
Motor Sequence ◽  
Wave Dynamics ◽  
Sequence Memory ◽  
Phase Amplitude

AbstractThe slow-waves (SW) of non-rapid eye movement sleep (NREM) reflect neocortical components of network activity during sleep-dependent information processing; their disruption may therefore contribute to impaired memory consolidation. Here, we quantify SW dynamics relative to motor sequence memory in patients suffering schizophrenia and healthy volunteers.Patients showed normal intrinsic SW properties but impaired SW coherence, which failed to exhibit the learning-dependent increases evident in healthy volunteers. SW-spindle phase amplitude coupling across distributed EEG electrodes was also dissociated from experience in patients, with long-range fronto-parietal and -occipital networks most severely affected. Partial least squares regression modelling confirmed distributed SW coherence and SW-spindle coordination as predictors of overnight memory consolidation in healthy controls, but not in patients.Quantifying the full repertoire of NREM EEG oscillations and their long-range covariance therefore presents learning-dependent changes in distributed SW and spindle coordination as fingerprints of impaired cognition in schizophrenia.

Hippocampus and striatum: Dynamics and interaction during acquisition and sleep-related motor sequence memory consolidation

Hippocampus ◽  
2013 ◽  
Vol 23 (11) ◽  
pp. 985-1004 ◽  
Author(s):  
Geneviève Albouy ◽  
Bradley R. King ◽  
Pierre Maquet ◽  
Julien Doyon
Keyword(s):  
Memory Consolidation ◽  
Motor Sequence ◽  
Sequence Memory

Das Restless-Legs-Syndrom, eine diagnostische und therapeutische Herausforderung bei Kindern und Jugendlichen

2019 ◽  
Vol 19 (03) ◽  
pp. 194-199
Author(s):  
Silvano Vella
Keyword(s):  
Periodic Limb Movements ◽  
Wird Eine ◽  
Limb Movements ◽  
Kognitive Leistungsfähigkeit ◽  
Restless Legs ◽  
Restless Legs Syndrom

ZusammenfassungDas Restless-Legs-Syndrom (RLS) ist eine zentralnervöse, genetisch prädisponierte, durch biochemische Faktoren getriggerte chronisch-progrediente sensomotorische Störung, oft mit Beginn im Kindes- oder Jugendalter. Zugrundeliegend wird eine zerebrale Störung des Eisen- und Dopamin-Stoffwechsels postuliert. Diese manifestiert sich durch den unwiderstehlichen Zwang seine Extremitäten bewegen zu müssen, verbunden mit Parästhesien und Dysästhesien. Die Beschwerden nehmen in Ruhe und in der Nacht zu und bessern sich durch Bewegung. RLS sollte eigentlich mit Restless-Limbs-Syndrome übersetzt werden, da langfristig auch Beschwerden in den Armen auftreten können. Kinder ab 18 Monaten können bereits betroffen sein. Die Prävalenz im Kindes- und Jugendalter beträgt 2–4 %, in Assoziation mit ADHS noch höher. Die Diagnose des RLS beruht auf anamnestischen und somit subjektiv geprägten Aussagen, die bei Kindern mit beschränkten sprachlichen Ausdrucksmöglichkeiten schwierig zu werten sind. Bis zu 75 % der RLS-Betroffenen entwickeln im Schlaf periodische Extremitätenbewegungen, welche die Nachtruhe empfindlich stören können (PLMS, periodic limb movements in sleep). Mitbetroffen sind die kognitive Leistungsfähigkeit, Stimmung und Lebensqualität am Tag. Eisenmangel, Genussmittel und gewisse Medikamente können die Beschwerden verstärken. Im Gegensatz zum RLS können PLMS mit neurophysiologischen Messungen objektiviert werden. Therapeutisch steht an erster Stelle die Behandlung eines allfälligen Eisenmangels. Entwickelt wurden Algorithmen für intravenöse Therapien. Falls angezeigt, kommen L-Dopa oder Dopamin-Agonisten zur Anwendung. Da auch Kinder eine Zunahme der RLS-Symptome unter dieser Therapie erleben (Augmentationen), wird zunehmend eine primäre Gabe von Alpha-2-Liganden bevorzugt.Dieser Artikel möchte auf die wichtige Aufgabe von Kinderärzten und Grundversorgern bei der rechtzeitigen Erkennung und Behandlung von RLS/PLMS hinweisen.

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