scholarly journals A Tail of Kinase Regulation: How C‐termini Modulate CK1 Substrate Phosphorylation

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Sierra Cullati ◽  
Jun‐Song Chen ◽  
Kathy Gould
Diabetes ◽  
1990 ◽  
Vol 39 (2) ◽  
pp. 250-259 ◽  
Author(s):  
R. S. Thies ◽  
J. M. Molina ◽  
T. P. Ciaraldi ◽  
G. R. Freidenberg ◽  
J. M. Olefsky

1991 ◽  
Vol 266 (30) ◽  
pp. 19908-19916 ◽  
Author(s):  
R. Herbst ◽  
R. Lammers ◽  
J. Schlessinger ◽  
A. Ullrich

2021 ◽  
Vol 7 (23) ◽  
pp. eabg0007
Author(s):  
Deniz Pirincci Ercan ◽  
Florine Chrétien ◽  
Probir Chakravarty ◽  
Helen R. Flynn ◽  
Ambrosius P. Snijders ◽  
...  

Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities of successive cyclin waves. Alternatively, in the quantitative model, the gradual rise of Cdk activity from G1 phase to mitosis leads to ordered substrate phosphorylation at sequential thresholds. Here, we study the relative contributions of qualitative and quantitative Cdk control in Saccharomyces cerevisiae. All S phase and mitotic cyclins can be replaced by a single mitotic cyclin, albeit at the cost of reduced fitness. A single cyclin can also replace all G1 cyclins to support ordered cell cycle progression, fulfilling key predictions of the quantitative model. However, single-cyclin cells fail to polarize or grow buds and thus cannot survive. Our results suggest that budding yeast has become dependent on G1 cyclin specificity to couple cell cycle progression to essential morphogenetic events.


Sign in / Sign up

Export Citation Format

Share Document