scholarly journals Diverse Roles of G‐Protein‐Coupled Receptor 40 (GPR40/FFA1) and GPR120 (FFA4) in the Regulation of Cell Growth and Motile Activities in Renal Cell Carcinoma (RCC)

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Priyanka Karmokar ◽  
Nader Moniri
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
G Protein ◽  
Renal Cell ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma

2021 ◽  
Vol 18 (3) ◽  
pp. 207-220
Author(s):  
SHAO-KUAN CHEN ◽  
YEN-CHIEH WANG ◽  
TAI-YUAN LIN ◽  
HSIN-JOU WU ◽  
CHI-JUNG HUANG ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Estrogen Receptor ◽  
Cell Carcinoma ◽  
G Protein ◽  
Renal Cell ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

scholarly journals Activation of G protein coupled estrogen receptor (GPER) promotes the migration of renal cell carcinoma via the PI3K/AKT/MMP-9 signals

2018 ◽  
Vol 12 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Bao-zhang Guan ◽  
Rui-ling Yan ◽  
Jian-Wei Huang ◽  
Fo-Lan Li ◽  
Ying-Xue Zhong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Estrogen Receptor ◽  
Cell Carcinoma ◽  
G Protein ◽  
Renal Cell ◽  
G Protein Coupled

scholarly journals Downregulation of miR-193a-3p inhibits cell growth and migration in renal cell carcinoma by targeting PTEN

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831771195 ◽  
Author(s):  
Lingqi Liu ◽  
Yanqin Li ◽  
Shuchao Liu ◽  
Qixin Duan ◽  
Liang Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals Bromodomain-Containing Protein 4 (BRD4) Inhibition Sensitizes Palomid 529-Induced Anti-Renal Cell Carcinoma Cell Activity in Vitro and in Vivo

2018 ◽  
Vol 50 (2) ◽  
pp. 640-653 ◽  
Author(s):  
Zhao-yu Xing ◽  
Yin Wang ◽  
Long Cheng ◽  
Jie Chen ◽  
Xiao-zhou He ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Cell Apoptosis ◽  
Renal Cell ◽  
Elisa Assay ◽  
Dual Inhibitor ◽  
Brd4 Inhibition

Background/Aims: Mammalian target of rapamycin (mTOR) is a valuable treatment target of renal cell carcinoma (RCC). Palomid 529 is a novel mTORC1/2 dual inhibitor. Methods: RCC cells were treated with different concentrations of Palomid 529. Cell survival was tested by MTT assay and clonogenicity assay. Cell proliferation was tested by BrdU ELISA assay. Cell apoptosis was tested by the Hoechst-33342 nuclei staining assay and Histone DNA ELISA assay. mTOR signaling was tested by Western blotting assay and co-immunoprecipitation (IP) assay. The SCID mouse 786-O xenograft model was established to test RCC cell growth in vivo. Results: Palomid 529 exerted cytotoxic, anti-proliferative and pro-apoptotic activities in 786-O RCC cells. Palomid 529 disassembled mTORC1/2, causing de-phosphorylation of mTORC1/2 substrates. Bromodomain-containing protein 4 (BRD4) is a primary resistant factor of Palomid 529. Palomid 529-induced 786-O cell apoptosis was sensitized by BRD4 inhibitors or BRD4 silencing, but inhibited with BRD4 over-expression. Palomid 529-induced cytotoxicity in the primary human RCC cells was negatively correlated with BRD4 expression level. In vivo, Palomid 529 i.p. administration inhibited 786-O xenograft tumor growth in SCID mice. Its anti-tumor activity was further sensitized by co-administration of the BRD4 inhibitor JQ1. Cconclusion: Palomid 529 inhibits RCC cell growth in vitro and in vivo. BRD4 inhibition could further sensitize Palomid 529 against RCC cells.

scholarly journals MP72-13 EFFECT OF A KETOGENIC DIET ON THE CLEAR CELL RENAL CELL CARCINOMA CELL GROWTH

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Maxime Benoit ◽  
Edouard Fortier ◽  
Magalie Barth ◽  
Vincent Procaccio ◽  
Jennifer Bourreau ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Ketogenic Diet ◽  
Renal Cell ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell

Phosphofructokinase-M inhibits cell growth via modulating the FOXO3 pathway in renal cell carcinoma cells

2020 ◽  
Vol 530 (1) ◽  
pp. 67-74
Author(s):  
Yeda Chen ◽  
Qingfeng Yu ◽  
Xiaolu Duan ◽  
Wenqi Wu ◽  
Guohua Zeng
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells

Effect of a ketogenic diet on the clear cell renal cell carcinoma cell growth

2018 ◽  
Vol 17 (2) ◽  
pp. e57-e59
Author(s):  
M. Benoit ◽  
E. Fortier ◽  
M. Barth ◽  
V. Procaccio ◽  
J. Bourreau ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Growth ◽  
Cell Carcinoma ◽  
Ketogenic Diet ◽  
Renal Cell ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Cell Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Cell
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