scholarly journals Inhibitory Effect of Ethanol Extract from Folium et Ramulus Securinegae on TNF‐α induced vascular inflammation in Human Umbilical Vein Endothelial Cells

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Byung Hyuk Han ◽  
Chun Ho Song ◽  
Chang Seob Seo ◽  
Dae Gill Kang ◽  
Yun Jung Lee ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Human Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells

scholarly journals Inhibitory effect of brassinin on TNF-α-induced vascular inflammation in human umbilical vein endothelial cells

2017 ◽  
Vol 16 (5) ◽  
pp. 6890-6895 ◽  
Author(s):  
Byung Hyuk Han ◽  
Jung Joo Yoon ◽  
Eun Sik Choi ◽  
Da Hye Jeong ◽  
Yun Jung Lee ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Inhibitory Effect ◽  
Human Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells

Anti-Inflammatory Effect of Buddleja officinalis on Vascular Inflammation in Human Umbilical Vein Endothelial Cells

2010 ◽  
Vol 38 (03) ◽  
pp. 585-598 ◽  
Author(s):  
Yun Jung Lee ◽  
Mi Kyoung Moon ◽  
Sun Mi Hwang ◽  
Jung Joo Yoon ◽  
So Min Lee ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Human Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells ◽  
Cell Adhesion Molecule 1

Vascular inflammation process has been suggested to be an important risk factor in the initiation and development of atherosclerosis. In this study, we investigated whether and by what mechanisms an aqueous extract of Buddleja officinalis (ABO) inhibited the expressions of cellular adhesion molecules, which are relevant to inflammation and atherosclerosis. Pretreatment of human umbilical vein endothelial cells (HUVEC) with ABO (1–10 μg/ml) for 18 hours dose-dependently inhibited TNF-α-induced adhesion U937 monocytic cells, as well as mRNA and protein expressions of vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1). Pretreatment with ABO also blocked TNF-α-induced ROS formation. Nuclear factor-kappa B (NF-κB) is required in the transcription of these adhesion molecule genes. Western blot analysis revealed that ABO inhibits the translocation of the p65 subunit of NF-κB to the nucleus. ABO inhibited the TNF-α-induced degradation of IκB-α, an inhibitor of NF-κB, by inhibiting the phosphorylation of IκB-α in HUVEC. Taken together, ABO could reduce cytokine-induced endothelial adhesiveness throughout down-regulating intracellular ROS production, NF-κB, and adhesion molecule expression in HUVEC, suggesting that the natural herb Buddleja officinalis may have potential implications in atherosclerosis.

Effect of Zanthoxylum schinifolium on TNF-α-induced vascular inflammation in human umbilical vein endothelial cells

2009 ◽  
Vol 50 (5-6) ◽  
pp. 200-207 ◽  
Author(s):  
Li Hua Cao ◽  
Yun Jung Lee ◽  
Dae Gill Kang ◽  
Jin Sook Kim ◽  
Ho Sub Lee
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Human Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells ◽  
Zanthoxylum Schinifolium

Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway

2018 ◽  
Vol 9 (4) ◽  
pp. 2386-2397 ◽  
Author(s):  
Juan Chen ◽  
Minghua Zhang ◽  
Maomao Zhu ◽  
Junfei Gu ◽  
Jie Song ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Signaling Pathway ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Inhibitory Effect ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Paeoniflorin has inhibitory effect on ER stress-associated vascular inflammation.

scholarly journals Effect of Paeotang on TNF‐α‐induced vascular inflammation in human umbilical vein endothelial cells (1158.4)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Dae Hwan Kim ◽  
Yun Jung Lee ◽  
Jung Joo Yoon ◽  
So Min Lee ◽  
Dae Gill Kang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Vascular Inflammation ◽  
Human Umbilical Vein ◽  
Tnf Α ◽  
Umbilical Vein Endothelial Cells
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