Probing The Structural Basis of Metabotropic Glutamate Receptor 5 (mGlu
            5
            ) Activation and Positive Allosteric Modulation

Md Abdur Razzak; Karen Gregory; Katie Leach; Shane Hellyer

doi:10.1096/fasebj.2021.35.s1.03361

Probing The Structural Basis of Metabotropic Glutamate Receptor 5 (mGlu 5 ) Activation and Positive Allosteric Modulation

The FASEB Journal ◽

10.1096/fasebj.2021.35.s1.03361 ◽

2021 ◽

Vol 35 (S1) ◽

Author(s):

Md Abdur Razzak ◽

Karen Gregory ◽

Katie Leach ◽

Shane Hellyer

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulation ◽

Structural Basis ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the μ-opioid receptor

Neuropharmacology ◽

10.1016/j.neuropharm.2008.12.010 ◽

2009 ◽

Vol 56 (4) ◽

pp. 768-778 ◽

Cited By ~ 43

Author(s):

H. Schröder ◽

D.-F. Wu ◽

A. Seifert ◽

M. Rankovic ◽

S. Schulz ◽

...

Keyword(s):

Opioid Receptor ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulation ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Μ Opioid Receptor

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulation Effects on Microglia Phenotype

10.22215/etd/2021-14640 ◽

2021 ◽

Author(s):

Natasha Curtis

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulation ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

Loss of Object Recognition Memory Produced by Extended Access to Methamphetamine Self-Administration is Reversed by Positive Allosteric Modulation of Metabotropic Glutamate Receptor 5

Neuropsychopharmacology ◽

10.1038/npp.2010.212 ◽

2010 ◽

Vol 36 (4) ◽

pp. 782-792 ◽

Cited By ~ 81

Author(s):

Carmela M Reichel ◽

Marek Schwendt ◽

Jacqueline F McGinty ◽

M Foster Olive ◽

Ronald E See

Keyword(s):

Object Recognition ◽

Recognition Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulation ◽

Self Administration ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Object Recognition Memory ◽

Extended Access

Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection

Neuroscience Letters ◽

10.1016/j.neulet.2011.10.007 ◽

2011 ◽

Vol 505 (2) ◽

pp. 140-145 ◽

Cited By ~ 24

Author(s):

Thomas M. Piers ◽

Simon J. Heales ◽

Jennifer M. Pocock

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulation ◽

Metabotropic Glutamate Receptor 5 ◽

Neuronal Protection ◽

Activated Microglia ◽

Metabotropic Glutamate

The Effects of MPEP, a Selective Metabotropic Glutamate Receptor 5 Antagonist, on Conditioned Taste Aversion in Rats

PsycEXTRA Dataset ◽

10.1037/e413812005-369 ◽

2002 ◽

Author(s):

Todd R. Schachtman ◽

Carla Bills ◽

Rodica Ghinescu ◽

Kevin Murch ◽

Agnes Simonyi

Keyword(s):

Taste Aversion ◽

Glutamate Receptor ◽

Conditioned Taste Aversion ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

Faculty Opinions recommendation of Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006551.81756 ◽

2002 ◽

Author(s):

David Jane

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Structural Basis ◽

Metabotropic Glutamate

Faculty Opinions recommendation of Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718499023.793498248 ◽

2014 ◽

Author(s):

Roland Seifert

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Transmembrane Domain ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Class C

Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine

Neuroscience Letters ◽

10.1016/j.neulet.2020.135552 ◽

2021 ◽

Vol 743 ◽

pp. 135552

Author(s):

Yingying Niu ◽

Xiaoxu Zeng ◽

Guangcheng Qin ◽

Dunke Zhang ◽

Jiying Zhou ◽

...

Keyword(s):

Chronic Migraine ◽

Glutamate Receptor ◽

Rat Model ◽

Central Sensitization ◽

Metabotropic Glutamate Receptor ◽

Mtor Pathway ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience ◽

10.1016/j.neuroscience.2006.06.043 ◽

2006 ◽

Vol 142 (3) ◽

pp. 691-702 ◽

Cited By ~ 67

Author(s):

D. Balschun ◽

W. Zuschratter ◽

W. Wetzel

Keyword(s):

Spatial Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate