scholarly journals SPDEF targets EMT pathway to inhibit cell migration and invasion in triple‐negative breast cancer

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Hassan Yousefi ◽  
Mousa Vatanmakanian ◽  
Sweaty Koul ◽  
Samuel Okpechi ◽  
Suresh Alahari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer

2014 ◽  
Vol 22 (3) ◽  
pp. 889-898 ◽  
Author(s):  
Hsin-An Chen ◽  
Yi-Wen Chang ◽  
Chi-Feng Tseng ◽  
Ching-Feng Chiu ◽  
Chih-Chen Hong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals LncRNA MIR503HG inhibits cell migration and invasion via miR‐103/OLFM4 axis in triple negative breast cancer

2019 ◽  
Vol 23 (7) ◽  
pp. 4738-4745 ◽  
Author(s):  
Jia Fu ◽  
Guanjun Dong ◽  
Hui Shi ◽  
Junfeng Zhang ◽  
Zhaochen Ning ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy

2020 ◽  
Vol 19 (16) ◽  
pp. 1983-1990 ◽  
Author(s):  
Hui-Yuan Lu ◽  
Jian-Sheng Zhu ◽  
Zhan Zhang ◽  
Wei-Jian Shen ◽  
Shan Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Viability ◽  
Triple Negative Breast Cancer ◽  
Molecular Mechanisms ◽  
Triple Negative ◽  
Chemotherapeutic Agents ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Cell Migration And Invasion

Background: Breast Cancer (BC) is the leading cause of cancer-related deaths among women. As such, novel chemotherapeutic agents are urgently needed, especially for Triple-Negative Breast Cancer (TNBC). Hydroxytyrosol (HT) and Oleuropein (OL) are rich in olive oil, which is associated with a low occurrence of BC. However, the effects and mechanisms of action of HT and OL in BC cells are still unclear. This study aimed to explore the molecular mechanisms underlying the antitumor effect of HT and OL in TNBC. Methods: TNBC MDA-MB-231 cells were treated with HT and OL in combination with Hepatocyte Growth Factor (HGF), rapamycin (Rapa, an inducer of autophagy) or 3-methyladenine (3-MA, an inhibitor of autophagy). Cell viability, migration, invasion, and autophagy signaling were analyzed by scratch assays, transwell migration assays, and Western blot analysis. Results: Treatment with HT or OL reduced MDA-MB-231 cell viability in a dose-dependent manner. MDAMB- 231 cells were more sensitive to HT treatment than OL treatment. Rapa treatment could significantly block HGF-induced MDA-MB-231 cell migration and invasion, suggesting that inhibition of autophagy could promote migration and invasion. Moreover, HT or OL treatment significantly suppressed HGF or 3-MA induced cell migration and invasion by reversing LC3-II/LC3-I and Beclin-1 downregulation and reversing p62 upregulation. Conclusion: These data indicated that HT and OL may inhibit migration and invasion of TNBC cells by activating autophagy. These findings provide potential therapeutic strategies that target autophagy to limit the pathogenesis and progression of BC.

scholarly journals PRAME, cell migration and invasion of triple negative breast cancer cells

2017 ◽  
Vol 28 ◽  
pp. xi26
Author(s):  
B. Al-Sulaiti ◽  
A. Naser ◽  
R. Thomas ◽  
G. Al-Khadairi ◽  
J. Decock
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer

2018 ◽  
Vol 44 ◽  
pp. 33-42 ◽  
Author(s):  
Huaping Xiong ◽  
Ting Yan ◽  
Weijie Zhang ◽  
Fangfang Shi ◽  
Xuesong Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer

2017 ◽  
Vol 24 (S3) ◽  
pp. 685-686
Author(s):  
Hsin-An Chen ◽  
Yi-Wen Chang ◽  
Chi-Feng Tseng ◽  
Ching-Feng Chiu ◽  
Chih-Chen Hong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Migration And Invasion ◽  
Cell Migration And Invasion
Sign in / Sign up

Export Citation Format

Share Document