BIOSPUN VASCULAR GRAFTS: IN VIVO EVALUATION OF A NOVEL SMALL‐DIAMETER BIOACTIVE NANOFIBROUS VASCULAR GRAFT FOR ARTERIAL RECONSTRUCTION

2008 ◽  
Vol 22 (S2) ◽  
pp. 605-605
Author(s):  
Mauricio Antonio Contreras ◽  
Mathew Douglas Phaneuf ◽  
Shengqian Wu ◽  
Martin J. Bide ◽  
Frank W. LoGerfo
Keyword(s):  
Vascular Graft ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Arterial Reconstruction ◽  
In Vivo Evaluation

Chitosan-based hydrogels for developing a small-diameter vascular graft: in vitro and in vivo evaluation

2017 ◽  
Vol 12 (6) ◽  
pp. 065003 ◽  
Author(s):  
A Aussel ◽  
N B Thébaud ◽  
X Bérard ◽  
V Brizzi ◽  
S Delmond ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Small Diameter ◽  
In Vivo Evaluation

In vivo evaluation of an elastomeric small‐diameter vascular graft reinforced with a highly flexible Nitinol mesh

2018 ◽  
Vol 107 (4) ◽  
pp. 951-964 ◽  
Author(s):  
Giorgio Soldani ◽  
Michele Murzi ◽  
Francesco Faita ◽  
Nicole Di Lascio ◽  
Tamer Al Kayal ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Small Diameter ◽  
In Vivo Evaluation

Antithrombogenic surface modifications in xenogenic pericardial vascular grafts: Initial in-vivo evaluation

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
J Linneweber ◽  
F Voss ◽  
P Dohmen ◽  
W Erdbrügger ◽  
W Konertz
Keyword(s):  
Vascular Grafts ◽  
Surface Modifications ◽  
In Vivo Evaluation

scholarly journals Decellularised Human Umbilical Artery as a Vascular Graft Elicits Minimal Pro-Inflammatory Host Response Ex Vivo and In Vivo

2021 ◽  
Vol 22 (15) ◽  
pp. 7981
Author(s):  
Alexander Høgsted Ahlmann ◽  
Shu Fang ◽  
Sussi Bagge Mortensen ◽  
Line Weis Andersen ◽  
Pernille Gejl Pedersen ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Umbilical Artery ◽  
Ex Vivo ◽  
White Blood Cells ◽  
Small Diameter ◽  
M1 Macrophages ◽  
Host Immune Responses ◽  
Cytokine Levels ◽  
Anti Inflammatory Cytokine

Small diameter (<6 mm) vessel grafts still pose a challenge for scientists worldwide. Decellularised umbilical artery (dUA) remains promising as small diameter tissue engineered vascular graft (TEVG), yet their immunogenicity remains unknown. Herein, we evaluated the host immune responses, with a focus on the innate part, towards human dUA implantation in mice, and confirmed our findings in an ex vivo allogeneic human setup. Overall, we did not observe any differences in the number of circulating white blood cells nor the number of monocytes among three groups of mice (1) dUA patch; (2) Sham; and (3) Mock throughout the study (day −7 to 28). Likewise, we found no difference in systemic inflammatory and anti-inflammatory cytokine levels between groups. However, a massive local remodelling response with M2 macrophages were observed in the dUA at day 28, whereas M1 macrophages were less frequent. Moreover, human monocytes from allogeneic individuals were differentiated into macrophages and exposed to lyophilised dUA to maximize an eventual M1 response. Yet, dUA did not elicit any immediate M1 response as determined by the absence of CCR7 and CXCL10. Together this suggests that human dUA elicits a minimal pro-inflammatory response further supporting its use as a TEVG in an allogeneic setup.

scholarly journals Review: Tissue Engineering of Small-Diameter Vascular Grafts and Their In Vivo Evaluation in Large Animals and Humans

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 713
Author(s):  
Shu Fang ◽  
Ditte Gry Ellman ◽  
Ditte Caroline Andersen
Keyword(s):  
Animal Models ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Large Animal ◽  
Large Animal Models ◽  
Graft Outcome ◽  
Limited Success ◽  
Large Animals

To date, a wide range of materials, from synthetic to natural or a mixture of these, has been explored, modified, and examined as small-diameter tissue-engineered vascular grafts (SD-TEVGs) for tissue regeneration either in vitro or in vivo. However, very limited success has been achieved due to mechanical failure, thrombogenicity or intimal hyperplasia, and improvements of the SD-TEVG design are thus required. Here, in vivo studies investigating novel and relative long (10 times of the inner diameter) SD-TEVGs in large animal models and humans are identified and discussed, with emphasis on graft outcome based on model- and graft-related conditions. Only a few types of synthetic polymer-based SD-TEVGs have been evaluated in large-animal models and reflect limited success. However, some polymers, such as polycaprolactone (PCL), show favorable biocompatibility and potential to be further modified and improved in the form of hybrid grafts. Natural polymer- and cell-secreted extracellular matrix (ECM)-based SD-TEVGs tested in large animals still fail due to a weak strength or thrombogenicity. Similarly, native ECM-based SD-TEVGs and in-vitro-developed hybrid SD-TEVGs that contain xenogeneic molecules or matrix seem related to a harmful graft outcome. In contrast, allogeneic native ECM-based SD-TEVGs, in-vitro-developed hybrid SD-TEVGs with allogeneic banked human cells or isolated autologous stem cells, and in-body tissue architecture (IBTA)-based SD-TEVGs seem to be promising for the future, since they are suitable in dimension, mechanical strength, biocompatibility, and availability.

scholarly journals In vitro and in vivo Evaluation of Hemocompatibility of Silk Fibroin Based Artificial Vascular Grafts

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Derya Aytemiz ◽  
Yu Suzuki ◽  
Tomoko Shindo ◽  
Toshiki Saotome ◽  
Ryou Tanaka ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Vascular Grafts ◽  
In Vivo Evaluation

scholarly journals In vivo evaluation of biomimetic fluorosurfactant polymer-coated expanded polytetrafluoroethylene vascular grafts in a porcine carotid artery bypass model

2016 ◽  
Vol 63 (6) ◽  
pp. 1620-1630.e4 ◽  
Author(s):  
Jennifer M. Bastijanic ◽  
Roger E. Marchant ◽  
Faina Kligman ◽  
Matthew T. Allemang ◽  
Ryan O. Lakin ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Artery Bypass ◽  
Vascular Grafts ◽  
In Vivo Evaluation ◽  
Expanded Polytetrafluoroethylene ◽  
Porcine Carotid Artery

scholarly journals The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Ruiming Liu ◽  
Yuansen Qin ◽  
Huijin Wang ◽  
Yong Zhao ◽  
Zuojun Hu ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Blood Compatibility ◽  
Small Diameter

Tissue Engineered Small-Diameter Arterial Graft: In Vivo Evaluation of an Electrospun Nanofiber Scaffold

2013 ◽  
Vol 179 (2) ◽  
pp. 203
Author(s):  
K.A. Rocco ◽  
M.W. Maxfield ◽  
P.S. Bagi ◽  
H. Kurobe ◽  
T. Yi ◽  
...  
Keyword(s):  
Small Diameter ◽  
Arterial Graft ◽  
Electrospun Nanofiber ◽  
In Vivo Evaluation ◽  
Nanofiber Scaffold
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