scholarly journals Green tea extract (GTE) protects against nonalcoholic fatty liver disease (NAFLD) in obese mice by decreasing liver injury and improving enzymatic antioxidant defenses

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Dana Anne DiNatale ◽  
Hea Jin Park ◽  
Min‐Yu Chung ◽  
Sung Koo ◽  
Richard Bruno
2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Rodrigo Barros Freitas ◽  
Rômulo Dias Novaes ◽  
Reggiani Vilela Gonçalves ◽  
Bianca Gazolla Mendonça ◽  
Eliziária Cardoso Santos ◽  
...  

We investigated the effects ofE. edulisbioproducts (lyophilized pulp [LEE], defatted lyophilized pulp [LDEE], and oil [EO]) on nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in rats. All products were chemically analyzed.In vivo, 42 rats were equally randomized into seven groups receiving standard diet, HFD alone or combined with EO, LEE, or LDEE. After NAFLD induction, LEE, LDEE, or EO was added to the animals’ diet for 4 weeks. LEE was rich in polyunsaturated fatty acids. From LEE degreasing, LDEE presented higher levels of anthocyanins and antioxidant capacityin vitro. Dietary intake of LEE and especially LDEE, but not EO, attenuated diet-induced NAFLD, reducing inflammatory infiltrate, steatosis, and lipid peroxidation in liver tissue. Although bothE. edulisbioproducts were not hepatotoxic, only LDEE presented sufficient benefits to treat NAFLD in rats, possibly by its low lipid content and high amount of phenols and anthocyanins.


2009 ◽  
Vol 136 (5) ◽  
pp. A-845
Author(s):  
Valerio Nobili ◽  
Naim Alkhouri ◽  
Anna Alisi ◽  
Melania Manco ◽  
Andrea Bartuli ◽  
...  

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