scholarly journals Retinoic Acid Enhances Natriuretic Peptide Receptor‐A gene Transcription: Role of Additive Effect of Retinoic Acid Receptor‐α and Ets‐1

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Prerna Kumar ◽  
Gevoni Bolden ◽  
Kailash N Pandey
Keyword(s):  
Retinoic Acid ◽  
Natriuretic Peptide ◽  
Gene Transcription ◽  
Retinoic Acid Receptor ◽  
Natriuretic Peptide Receptor ◽  
Acid Receptor ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Retinoic Acid Receptor Α

scholarly journals The Importance of Natriuretic Peptides in Cardiometabolic Diseases

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Shravya Vinnakota ◽  
Horng H Chen
Keyword(s):  
Heart Failure ◽  
Natriuretic Peptide ◽  
Defense Mechanisms ◽  
Pressure Overload ◽  
Natriuretic Peptide Receptor ◽  
Therapeutic Role ◽  
Peptide Receptor ◽  
Genes Encoding ◽  
Natriuretic Peptide Receptor A

Abstract The natriuretic peptide (NP) system is composed of 3 distinct peptides (atrial natriuretic peptide or ANP, B-type natriuretic peptide or BNP, and C-type natriuretic peptide or CNP) and 3 receptors (natriuretic peptide receptor-A or NPR-A or particulate guanynyl cyclase-A natriuretic peptide receptor-B or NPR-B or particulate guanynyl cyclase-B, and natriuretic peptide receptor-C or NPR-C or clearance receptor). ANP and BNP function as defense mechanisms against ventricular stress and the deleterious effects of volume and pressure overload on the heart. Although the role of NPs in cardiovascular homeostasis has been extensively studied and well established, much remains uncertain about the signaling pathways in pathological states like heart failure, a state of impaired natriuretic peptide function. Elevated levels of ANP and BNP in heart failure correlate with disease severity and have a prognostic value. Synthetic ANP and BNP have been studied for their therapeutic role in hypertension and heart failure, and promising trials are under way. In recent years, the expression of ANP and BNP in human adipocytes has come to light. Through their role in promotion of adipocyte browning, lipolysis, lipid oxidation, and modulation of adipokine secretion, they have emerged as key regulators of energy consumption and metabolism. NPR-A signaling in skeletal muscles and adipocytes is emerging as pivotal to the maintenance of long-term insulin sensitivity, which is disrupted in obesity and reduced glucose-tolerance states. Genetic variants in the genes encoding for ANP and BNP have been associated with a favorable cardiometabolic profile. In this review, we discuss several pathways that have been proposed to explain the role of NPs as endocrine networkers. There is much to be explored about the therapeutic role of NPs in improving metabolic milieu.

scholarly journals The potential role of retinoic acid receptor α on glomerulosclerosis in rats and podocytes injury is associated with the induction of MMP2 and MMP9

2017 ◽  
Vol 49 (8) ◽  
pp. 669-679 ◽  
Author(s):  
Xiuping Chen ◽  
Yuanhan Qin ◽  
Tianbiao Zhou ◽  
Ling Jiang ◽  
Fengying Lei ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Potential Role ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α

735 Role of P38 MAPK in aldosterone-induced glomerular injury in natriuretic peptide receptor-A deficient mice

2012 ◽  
Vol 30 (Supplement 1) ◽  
pp. e213
Author(s):  
Yukiko Kato ◽  
Masashi Mukoyama ◽  
Hideki Yokoi ◽  
Yoshihisa Ogawa ◽  
Kiyoshi Mori ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Natriuretic Peptide ◽  
Natriuretic Peptide Receptor ◽  
Glomerular Injury ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A ◽  
Deficient Mice

The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse

2008 ◽  
Vol 294 (4) ◽  
pp. L714-L723 ◽  
Author(s):  
Jeffrey M. Dodd-o ◽  
Maria L. Hristopoulos ◽  
Kathleen Kibler ◽  
Jolanta Gutkowska ◽  
Suhayla Mukaddam-Daher ◽  
...  
Keyword(s):  
Lung Injury ◽  
Natriuretic Peptide ◽  
Ischemia Reperfusion ◽  
Intracellular Camp ◽  
Natriuretic Peptide Receptor ◽  
Intact Mouse ◽  
Peptide Receptor ◽  
Natriuretic Peptide Receptor A

Ischemia-reperfusion (IR) causes human lung injury in association with the release of atrial and brain natriuretic peptides (ANP and BNP), but the role of ANP/BNP in IR lung injury is unknown. ANP and BNP bind to natriuretic peptide receptor-A (NPR-A) generating cGMP and to NPR-C, a clearance receptor that can decrease intracellular cAMP. To determine the role of NPR-A signaling in IR lung injury, we administered the NPR-A blocker anantin in an in vivo SWR mouse preparation of unilateral lung IR. With uninterrupted ventilation, the left pulmonary artery was occluded for 30 min and then reperfused for 60 or 150 min. Anantin administration decreased IR-induced Evans blue dye extravasation and wet weight in the reperfused left lung, suggesting an injurious role for NPR-A signaling in lung IR. In isolated mouse lungs, exogenous ANP (2.5 nM) added to the perfusate significantly increased the filtration coefficient sevenfold only if lungs were subjected to IR. This effect of ANP was also blocked by anantin. Unilateral in vivo IR increased endogenous plasma ANP, lung cGMP concentration, and lung protein kinase G (PKGI) activation. Anantin enhanced plasma ANP concentrations and attenuated the increase in cGMP and PKGI activation but had no effect on lung cAMP. These data suggest that lung IR triggered ANP release and altered endothelial signaling so that NPR-A activation caused increased pulmonary endothelial permeability.

Critical Role of Tyrosine 277 in the Ligand-Binding and Transactivating Properties of Retinoic Acid Receptor α†

Biochemistry ◽  
2000 ◽  
Vol 39 (9) ◽  
pp. 2183-2192 ◽  
Author(s):  
Sandrine Mailfait ◽  
Denise Belaiche ◽  
Mostafa Kouach ◽  
Nathalie Dallery ◽  
Philippe Chavatte ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Ligand Binding ◽  
Retinoic Acid Receptor ◽  
Critical Role ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α
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