The elevated serum Monocyte Chemoattractant Protein‐1 (MCP‐1) in obesity is influenced by parathyroid hormone (PTH) and not body mass index (BMI)

Body mass index (BMI) and breast cancer biomarkers such as resistin, leptin adiponectin, monocyte chemoattractant protein-1 (MCP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) are highly associated with each other. The report has focused the inter-relationship between BMI and breast cancer biomarkers based on probabilistic modeling. It has been shown that mean BMI is positively associated with leptin (P<0.0001) and MCP-1 (P=0.0002), while it is negatively associated with adiponectin (P=0.0003), HOMA-IR (P<0.0001), and it is higher for healthy women (P=0.0116) than breast cancer women. In addition, variance of BMI is negatively associated with resistin (P=0.1450). On the other hand, mean MCP-1 is positively associated with BMI (P<0.0001). Mean resistin is positively associated with the interaction effect of BMI and leptin (BMI*Leptin) (P=0.0415), while its variance is positively associated with BMI (P=0.0942), and it is negatively associated with BMI*Adiponectin (P=0.1518). Leptin is positively associated with BMI (P<0.0001). Also adiponectin is negatively associated with BMI (P<0.0001), BMI*Leptin (P=0.1729), while it is positively associated with Age*BMI (P=0.0017) and BMI*Resistin (P=0.0615). It can be concluded that BMI and breast cancer biomarkers are strongly associated with each other. Care should be taken on BMI for breast cancer women.

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Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone

Journal of Bone and Mineral Research ◽

10.1002/jbmr.1933 ◽

2013 ◽

Vol 28 (9) ◽

pp. 1975-1986 ◽

Cited By ~ 29

Author(s):

Joseph A Tamasi ◽

Anatoliy Vasilov ◽

Emi Shimizu ◽

Noah Benton ◽

Joshua Johnson ◽

...

Keyword(s):

Parathyroid Hormone ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Anabolic Action

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Association of monocyte CCR2 expression with obesity and insulin resistance in postmenopausal women

Clinical & Investigative Medicine ◽

10.25011/cim.v36i1.19402 ◽

2013 ◽

Vol 36 (1) ◽

pp. 24 ◽

Cited By ~ 8

Author(s):

Vlatka Pandzic Jaksic ◽

Branimir Gizdic ◽

Zorana Miletic ◽

Karmen Trutin-Ostovic ◽

Ozren Jaksic

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Weight ◽

Oxidative Burst ◽

C Reactive Protein ◽

Monocyte Activation ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Reactive Protein ◽

Monocyte Chemoattractant Protein

Purpose: Monocytes actively participate in inflammatory mechanisms that contribute to the development of adipose tissue dysfunction and atherogenesis. The aim of this study was to evaluate the association of monocyte CCR2 chemokine receptor expression and intracellular oxidative burst with the metabolic and inflammatory factors related to body weight. Methods: The study was performed in 67 postmenopausal women with normal, overweight and obese body mass index. Monocyte CCR2 surface expression and intracellular oxidative burst activity (determined using 2', 7'-dichlorofluorescin diacetate) were analyzed by flow cytometry. Serum levels of HMW adoponectin, monocyte chemoattractant protein-1 (MCP-1), insulin, glucose, lipids and C-reactive protein were determined. Results: Subjects with homeostasis model assessment-estimated insulin resistance (HOMA-IR) above the median had significantly higher proportion of CCR2+ monocytes and higher mean fluorescence intensity (MFI) of CCR2 and oxidative burst. The proportion of CCR2+ monocytes and CCR2 MFI were correlated with body weight, body mass index, fat mass, insulin and HOMA-IR. Oxidative burst also correlated with anthropometric measures, fat mass and expression of CCR2. No correlations were found between these markers of monocyte activation and HMW adiponectin or monocyte chemoattractant protein-1. The absolute number of monocytes was associated with insulin and this association remained significant after adjusting for C-reactive protein. In the multiple regression model the monocyte number was determined to be an independent predictor of insulin level. Conclusion: These results provide support for significant associations of monocyte number and markers involved in monocyte activation with obesity and insulin resistance.

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