scholarly journals Predictive Value of the Mouse Model of Critical Limb Ischemia: Methodological Differences May Dictate the Outcome of Preclinical Efficacy

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Ben Brooks ◽  
Jeff McKee
Keyword(s):  
Mouse Model ◽  
Critical Limb Ischemia ◽  
Predictive Value ◽  
Limb Ischemia ◽  
Preclinical Efficacy

scholarly journals Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia

Antioxidants ◽  
2017 ◽  
Vol 6 (3) ◽  
pp. 47 ◽  
Author(s):  
Sally Elshaer ◽  
Islam Mohamed ◽  
Maha Coucha ◽  
Sara Altantawi ◽  
Wael Eldahshan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Critical Limb Ischemia ◽  
High Fat Diet ◽  
Limb Ischemia ◽  
High Fat ◽  
Impaired Angiogenesis

scholarly journals Magnetic Resonance Imaging Allows the Evaluation of Tissue Damage and Regeneration in a Mouse Model of Critical Limb Ischemia

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142111 ◽  
Author(s):  
Germana Zaccagnini ◽  
Anna Palmisano ◽  
Tamara Canu ◽  
Biagina Maimone ◽  
Francesco M. Lo Russo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Critical Limb Ischemia ◽  
Tissue Damage ◽  
Limb Ischemia ◽  
Resonance Imaging

scholarly journals TRICKS Magnetic Resonance Angiography at 3-Tesla for Assessing Whole Lower Extremity Vascular Tree in Patients with High-Grade Critical Limb Ischemia: DSA and TASC II Guidelines Correlations

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Sheung-Fat Ko ◽  
Jiunn-Jye Sheu ◽  
Chen-Chang Lee ◽  
Chung-Cheng Huang ◽  
Fan-Yen Lee ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Image Quality ◽  
Magnetic Resonance Angiography ◽  
Critical Limb Ischemia ◽  
Predictive Value ◽  
Limb Ischemia ◽  
High Grade ◽  
Vascular Tree ◽  
Point Scale ◽  
Significant Stenosis

The entire vascular tree of 58 lower extremities with high-grade critical limb ischemia (CLI) was assessed with three-station time resolved imaging of contrast kinetics (TRICKS) magnetic resonance angiography (T-MRA) and correlated with digital subtraction angiography (DSA) examinations and Trans-Atlantic Inter-Society Consensus II (TASC II) guidelines. Kappa (κ) statistics were utilized to evaluate the agreement of stenosis scores (5-point scale; 0 normal to 4 occlusion) based on T-MRA and DSA. With DSA as the standard, significant stenosis instances (stenosis score ≥2) among vascular segments were compared. Theκ-statistics of image quality (4-point scale; 1 nondiagnostic to 4 excellent) of T-MRA and TASC II classification assessed by a radiologist and a vascular surgeon were also evaluated. Among 870 vascular segments, excellent agreement was observed between T-MRA and DSA (meanκ= 0.883) in revealing stenosis (mean stenosis score, 2.1  ±  1.3 versus 2.0  ±  1.3). T-MRA harbored overall high sensitivity (99.5%), specificity (93.6%), positive predictive value (95.4%), negative predictive value (99.6%), and accuracy (97.7%) in depicting significant stenosis. Excellent interobserver agreement (meanκ= 0.818) of superb image quality (mean score = 3.5–3.6) of T-MRA and outstanding agreement of TASC II classification of aortoiliac and femoral-popliteal lesions (κ= 0.912–0.917) between two raters further verified the clinical feasibility of T-MRA for treatment planning.

E-Selectin/AAV Gene Therapy Promotes Wound Healing in a Critical Limb Ischemia Mouse Model

2018 ◽  
Vol 52 ◽  
pp. 7-8
Author(s):  
Punam P. Parikh ◽  
Roberta M. Lassance-Soares ◽  
Hongwei Shao ◽  
Zhao-Jun Liu ◽  
Omaida C. Velazquez
Keyword(s):  
Gene Therapy ◽  
Wound Healing ◽  
Mouse Model ◽  
Critical Limb Ischemia ◽  
Limb Ischemia
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