scholarly journals Kaempferol ameliorates airway inflammation through Tyk2‐STAT1/3 signaling in human airway epithelial cells and ovalbumin‐challenged mice: role of interleukin‐8

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ju Hyun Gong ◽  
Young-Hee Kang
Keyword(s):  
Epithelial Cells ◽  
Airway Inflammation ◽  
Airway Epithelial Cells ◽  
Interleukin 8 ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

scholarly journals Role of Protein Kinase C‐alpha in Listeriolysin‐induced ENaC dysfunction in human airway epithelial cells

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Guang Yang ◽  
Richard White ◽  
Martin Leustik ◽  
Aluya Oseghale ◽  
Mario Marrero ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Kinase C ◽  
Protein Kinase C Alpha ◽  
Human Airway Epithelial Cells

scholarly journals A Novel Role of Protein Tyrosine Kinase2 in Mediating Chloride Secretion in Human Airway Epithelial Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e21991 ◽  
Author(s):  
Lihua Liang ◽  
Owen M. Woodward ◽  
Zhaohui Chen ◽  
Robert Cotter ◽  
William B. Guggino
Keyword(s):  
Epithelial Cells ◽  
Chloride Secretion ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Protein Tyrosine ◽  
Human Airway ◽  
Human Airway Epithelial Cells

scholarly journals The Role of Nox4 in Oxidative Stress–InducedMUC5ACOverexpression in Human Airway Epithelial Cells

2008 ◽  
Vol 39 (5) ◽  
pp. 598-609 ◽  
Author(s):  
Hyun Jik Kim ◽  
Young-Duck Park ◽  
Uk Yeol Moon ◽  
Jun-Hee Kim ◽  
Ju Hyun Jeon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

scholarly journals Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation

Nutrients ◽  
2011 ◽  
Vol 3 (11) ◽  
pp. 910-928 ◽  
Author(s):  
Chiara Murgia ◽  
Dion Grosser ◽  
Ai Q. Truong-Tran ◽  
Eugene Roscioli ◽  
Agnes Michalczyk ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Inflammation ◽  
Murine Model ◽  
Allergic Airway Inflammation ◽  
Airway Epithelial Cells ◽  
Zinc Transporter ◽  
Airway Epithelial ◽  
Human Airway ◽  
Apical Localization ◽  
Human Airway Epithelial Cells

The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells

2004 ◽  
Vol 287 (3) ◽  
pp. L584-L591 ◽  
Author(s):  
Steven G. Kelsen ◽  
Mark O. Aksoy ◽  
Yi Yang ◽  
Syed Shahabuddin ◽  
Judith Litvin ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Inflammation ◽  
Chemokine Receptor ◽  
Splice Variant ◽  
Constitutive Expression ◽  
Airway Epithelial Cells ◽  
Mrna Levels ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

Activation of the chemokine receptor CXCR3 by its cognate ligands induces several differentiated cellular responses important to the growth and migration of a variety of hematopoietic and structural cells. In the human respiratory tract, human airway epithelial cells (HAEC) release the CXCR3 ligands Mig/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. Simultaneous expression of CXCR3 by HAEC would have important implications for the processes of airway inflammation and repair. Accordingly, in the present study we sought to determine whether HAEC also express the classic CXCR3 chemokine receptor CXCR3-A and its splice variant CXCR3-B and hence may respond in autocrine fashion to its ligands. We found that cultured HAEC (16-HBE and tracheocytes) constitutively expressed CXCR3 mRNA and protein. CXCR3 mRNA levels assessed by expression array were ∼35% of β-actin expression. In contrast, CCR3, CCR4, CCR5, CCR8, and CX3CR1 were <5% β-actin. Both CXCR3-A and -B were expressed. Furthermore, tracheocytes freshly harvested by bronchoscopy stained positively for CXCR3 by immunofluorescence microscopy, and 68% of cytokeratin-positive tracheocytes (i.e., the epithelial cell population) were positive for CXCR3 by flow cytometry. In 16-HBE cells, CXCR3 receptor density was ∼78,000 receptors/cell when assessed by competitive displacement of 125I-labeled IP-10/CXCL10. Finally, CXCR3 ligands induced chemotactic responses and actin reorganization in 16-HBE cells. These findings indicate constitutive expression by HAEC of a functional CXC chemokine receptor, CXCR3. Our data suggest the possibility that autocrine activation of CXCR3 expressed by HAEC may contribute to airway inflammation and remodeling in obstructive lung disease by regulating HAEC migration.

scholarly journals Epithelial Na+ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1

2012 ◽  
Vol 166 (4) ◽  
pp. 1272-1289 ◽  
Author(s):  
Gordon B Watt ◽  
Noor AS Ismail ◽  
Agustin Garcia Caballero ◽  
Stephen C Land ◽  
Stuart M Wilson
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Na Channel ◽  
Airway Epithelial ◽  
Channel Activity ◽  
Human Airway ◽  
Epithelial Na Channel ◽  
Human Airway Epithelial Cells
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