scholarly journals Underlying mechanisms of tert‐butyl hydroperoxide induced vascular cell dysfunction and senescence in rats: in vivo and in vitro studies

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Yueh-Chiao Yeh ◽  
Tsun-Jui Liu ◽  
Jun-Chin Lo ◽  
Li-Chuan Wang ◽  
Chu-Ying Peng ◽  
...  
Keyword(s):  
In Vitro Studies ◽  
Vascular Cell ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Cell Dysfunction ◽  
Tert Butyl Hydroperoxide ◽  
Underlying Mechanisms

Protective mechanisms of Aralia continentalis extract against tert-butyl hydroperoxide-induced hepatotoxicity: In vivo and in vitro studies

2008 ◽  
Vol 46 (11) ◽  
pp. 3512-3521 ◽  
Author(s):  
Yong Pil Hwang ◽  
Jae Ho Choi ◽  
Eun Hee Han ◽  
Hyung Kyun Kim ◽  
Shin Keon Kang ◽  
...  
Keyword(s):  
In Vitro Studies ◽  
Protective Mechanisms ◽  
Aralia Continentalis ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Cytoprotective effects of pu-erh tea on hepatotoxicity in vitro and in vivo induced by tert-butyl-hydroperoxide

2010 ◽  
Vol 119 (2) ◽  
pp. 580-585 ◽  
Author(s):  
Pin-Der Duh ◽  
Bor-Sen Wang ◽  
Shiou-Jen Liou ◽  
Chia-Jung Lin
Keyword(s):  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Protective effect of extracts of Perilla frutescens treated with sucrose on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in vitro and in vivo

2012 ◽  
Vol 133 (2) ◽  
pp. 337-343 ◽  
Author(s):  
Sung-Yong Yang ◽  
Chung-oui Hong ◽  
Hojoung Lee ◽  
Sang-yul Park ◽  
Byung-gyu Park ◽  
...  
Keyword(s):  
Protective Effect ◽  
Perilla Frutescens ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

scholarly journals Sinensetin Reduces Osteoarthritis Pathology in the Tert-Butyl Hydroperoxide-Treated Chondrocytes and the Destabilization of the Medial Meniscus Model Mice via the AMPK/mTOR Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenxian Zhou ◽  
Yifeng Shi ◽  
Hui Wang ◽  
Caiyu Yu ◽  
Huanqing Zhu ◽  
...  
Keyword(s):  
Protective Effect ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Potential Candidate ◽  
Mtor Signaling Pathway ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

As a common degenerative disease, osteoarthritis (OA) usually causes disability in the elderly and socioeconomic burden. Previous studies have shown that proper autophagy has a protective effect on OA. Sinensetin (Sin) is a methylated flavonoid derived from citrus fruits. Studies have shown that Sin is a good autophagy inducer and has shown excellent therapeutic effects in a variety of diseases; however, its role in the treatment of OA is not fully understood. This study proved the protective effect of Sin on OA through a series of in vivo and in vitro experiments. In vitro experiments have shown that Sin may inhibit chondrocyte apoptosis induced by tert-butyl hydroperoxide (TBHP); at the same time, it might also inhibit the production of MMP13 and promote the production of aggrecan and collagen II. Mechanism studies have shown that Sin promotes chondrocyte autophagy by activating AMPK/mTOR signaling pathway. On the contrary, inhibition of autophagy can partially abolish the protective effect of Sin on TBHP-treated chondrocytes. In vivo experiments show that Sin may protect against DMM-induced OA pathogenesis. These results provide evidence that Sin serves as a potential candidate for the treatment of OA.

A mechanism of mitochondrial damage induced by tert-butyl hydroperoxide and microsomes in vitro

1990 ◽  
Vol 80 (2) ◽  
pp. 226-232
Author(s):  
Tomoaki Matsuo ◽  
Yumiko Kashiwaki ◽  
Saburo Itoo
Keyword(s):  
Mitochondrial Damage ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro

Life Sciences ◽  
2002 ◽  
Vol 71 (11) ◽  
pp. 1255-1266 ◽  
Author(s):  
Sunday O Awe ◽  
Ayotunde S.O Adeagbo
Keyword(s):  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Vascular Beds

A mechanism of mitochondrial damage induced by tert-butyl hydroperoxide and microsomes in vitro

1990 ◽  
Vol 80 (2) ◽  
pp. 226-232
Author(s):  
Tomoaki Matsuo ◽  
Yumiko Kashiwaki ◽  
Saburo Itoo
Keyword(s):  
Mitochondrial Damage ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide-induced rat hepatotoxicity

2002 ◽  
Vol 40 (5) ◽  
pp. 635-641 ◽  
Author(s):  
Chuen-Lan Liu ◽  
Jin-Ming Wang ◽  
Chia-Yih Chu ◽  
Ming-Tzong Cheng ◽  
Tsui-Hwa Tseng
Keyword(s):  
Protective Effect ◽  
Protocatechuic Acid ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide
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