scholarly journals Sphingosine‐1‐phosphate Modulates Aldosterone‐induced Epithelial Sodium Channel Subunit Trafficking in Renal Cortical Collecting Duct Cells

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Wei‐qing Han ◽  
Qing Zhu ◽  
Junping Hu ◽  
Pin‐Lan Li ◽  
Ningjun Li
Keyword(s):  
Sodium Channel ◽  
Collecting Duct ◽  
Epithelial Sodium Channel ◽  
Cortical Collecting Duct ◽  
Duct Cells ◽  
Sphingosine 1 Phosphate ◽  
Collecting Duct Cells

scholarly journals The Epithelial Sodium Channel (ENaC) Traffics to Apical Membrane in Lipid Rafts in Mouse Cortical Collecting Duct Cells

2007 ◽  
Vol 282 (52) ◽  
pp. 37402-37411 ◽  
Author(s):  
Warren G. Hill ◽  
Michael B. Butterworth ◽  
Huamin Wang ◽  
Robert S. Edinger ◽  
Jonathan Lebowitz ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Lipid Rafts ◽  
Apical Membrane ◽  
Collecting Duct ◽  
Epithelial Sodium Channel ◽  
Cortical Collecting Duct ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Epithelial Sodium Channel Enac

scholarly journals Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells

2021 ◽  
Vol 35 (5) ◽  
Author(s):  
Eric R. Barros Lamus ◽  
Valentina Carotti ◽  
Christine R. S. Vries ◽  
Femke Witsel ◽  
Onno J. Arntz ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Extracellular Vesicles ◽  
Purinergic Signaling ◽  
Collecting Duct ◽  
Epithelial Sodium Channel ◽  
Duct Cells ◽  
Channel Expression ◽  
Collecting Duct Cells ◽  
Renal Collecting Duct

scholarly journals Resveratrol Inhibits the Epithelial Sodium Channel via Phopshoinositides and AMP-Activated Protein Kinase in Kidney Collecting Duct Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78019 ◽  
Author(s):  
Kelly M. Weixel ◽  
Allison Marciszyn ◽  
Rodrigo Alzamora ◽  
Hui Li ◽  
Oliver Fischer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sodium Channel ◽  
Collecting Duct ◽  
Epithelial Sodium Channel ◽  
Kidney Collecting Duct ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Amp Activated Protein Kinase

Whole cell and unitary amiloride-sensitive sodium currents in M-1 mouse cortical collecting duct cells

1996 ◽  
Vol 270 (4) ◽  
pp. C998-C1010 ◽  
Author(s):  
M. L. Chalfant ◽  
T. G. O'Brien ◽  
M. M. Civan
Keyword(s):  
Collecting Duct ◽  
Cell Permeability ◽  
Na Channel ◽  
Na Channels ◽  
Cortical Collecting Duct ◽  
Ionic Selectivity ◽  
Whole Cell ◽  
Duct Cells ◽  
Excised Patches ◽  
Collecting Duct Cells

Amiloride-sensitive whole cell currents have been reported in M-1 mouse cortical collecting duct cells (Korbmacher et al., J. Gen. Physiol. 102: 761-793, 1993). We have confirmed that amiloride inhibits the whole cell currents but not necessarily the measured whole cell currents. Anomalous responses were eliminated by removing external Na+ and/or introducing paraepithelial shunts. The amiloride-sensitive whole cell currents displayed Goldman rectification. The ionic selectivity sequence of the amiloride-sensitive conductance was Li+ > Na+ >> K+. Growth of M-1 cells on permeable supports increased the amiloride-sensitive whole cell permeability, compared with cells grown on plastic. Single amiloride-sensitive channels were observed, which conformed to the highly selective low-conductance amiloride-sensitive class [Na(5)] of epithelial Na+ channels. Hypotonic pretreatment markedly slowed run-down of channel activity. The gating of the M-1 Na+ channel in excised patches was complex. Open- and closed-state dwell-time distributions from patches that display one operative channel were best described with two or more exponential terms each. We conclude that 1) study of M-1 whole cell Na+ currents is facilitated by reducing the transepithelial potential to zero, 2) these M-1 currents reflect the operation of Na(5) channels, and 3) the Na+ channels display complex kinetics, involving > or = 2 open and > or = 2 closed states.

scholarly journals Lipidomic and proteomic analysis of exosomes from mouse cortical collecting duct cells

2017 ◽  
Vol 31 (12) ◽  
pp. 5399-5408 ◽  
Author(s):  
Viet D. Dang ◽  
Kishore Kumar Jella ◽  
Ragy R. T. Ragheb ◽  
Nancy D. Denslow ◽  
Abdel A. Alli
Keyword(s):  
Proteomic Analysis ◽  
Collecting Duct ◽  
Cortical Collecting Duct ◽  
Duct Cells ◽  
Collecting Duct Cells
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