scholarly journals Comparative characterization of Taq DNA polymerase mutants capable of recognizing 2' modified nucleotides (967.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Aaron Leconte ◽  
Hannah Chia ◽  
Emma Hadley ◽  
Andrea Gochi ◽  
Alfredo Valencia
Keyword(s):  
Dna Polymerase ◽  
Modified Nucleotides ◽  
Taq Dna Polymerase ◽  
Comparative Characterization ◽  
Polymerase Mutants

scholarly journals Efforts towards crystallization of Taq DNA polymerase mutants (967.4)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Alfredo Valencia ◽  
Jacqueline Kroll ◽  
Matthew Sazinsky ◽  
Aaron Leconte
Keyword(s):  
Dna Polymerase ◽  
Taq Dna Polymerase ◽  
Polymerase Mutants

scholarly journals Characterization of the DNA polymerase gene of varicella-zoster viruses resistant to acyclovir

2001 ◽  
Vol 82 (11) ◽  
pp. 2761-2765 ◽  
Author(s):  
Tomoko Kamiyama ◽  
Masahiko Kurokawa ◽  
Kimiyasu Shiraki
Keyword(s):  
Amino Acid ◽  
Dna Polymerase ◽  
Sequence Similarity ◽  
Polymerase Gene ◽  
Varicella Zoster ◽  
Dna Polymerase Gene ◽  
Simplex Virus ◽  
Polymerase Mutants ◽  
Hsv 1

The nucleotide changes of the DNA polymerase gene and the susceptibility of acyclovir (ACV)-resistant varicella-zoster virus (VZV) mutants to anti-herpetic drugs were determined and compared to those of herpes simplex virus type 1 (HSV-1) mutants. The seven ACV-resistant VZV mutants were classified into three groups, N779S, G805C and V855M, according to the sequences of their DNA polymerase genes. The amino acid substitutions N779S and G805C were identical in position to the N815S and G814C mutations in the HSV-1 DNA polymerase mutants, respectively, and the V855M amino acid substitution was similar to the HSV-1 V892M mutation. All three groups of VZV mutants were susceptible to ACV, phosphonoacetic acid, vidarabine and aphidicolin, at levels similar to those seen with the respective HSV-1 mutants, except for subtle differences that were due possibly to the non-conserved regions in their sequences. Although both the HSV-1 and the VZV DNA polymerase genes show 53% sequence similarity, both viruses essentially show a similar biochemical behaviour.

Steady-State Kinetic Characterization of RB69 DNA Polymerase Mutants Τhat Affect dNTP Incorporation†

Biochemistry ◽  
1999 ◽  
Vol 38 (25) ◽  
pp. 8094-8101 ◽  
Author(s):  
Guangwei Yang ◽  
T.-C. Lin ◽  
J. Karam ◽  
W. H. Konigsberg
Keyword(s):  
Steady State ◽  
Dna Polymerase ◽  
Kinetic Characterization ◽  
Steady State Kinetic ◽  
Polymerase Mutants ◽  
State Kinetic

Taq DNA Polymerase Mutants and 2′-Modified Sugar Recognition

Biochemistry ◽  
2015 ◽  
Vol 54 (38) ◽  
pp. 5999-6008 ◽  
Author(s):  
Hayley J. Schultz ◽  
Andrea M. Gochi ◽  
Hannah E. Chia ◽  
Alexie L. Ogonowsky ◽  
Sharon Chiang ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Taq Dna Polymerase ◽  
Polymerase Mutants ◽  
Sugar Recognition

A Comprehensive Comparative Characterization of Keratinocytes; The Significant Wound Healing Agents

2016 ◽  
Vol 2 (2) ◽  
pp. 3
Author(s):  
Muhammad Irfan-maqsood ◽  
Hojjat Naderi-Meshkin ◽  
Asieh Heirani-Tabasi ◽  
Monireh Bahrami ◽  
Mahdi Mirahmadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Comparative Characterization
Sign in / Sign up

Export Citation Format

Share Document