scholarly journals Cerium Oxide Nanoparticles Confer Protection against Severe Sepsis Induced Hepatic Inflammation and Injury in Sprague Dawley Rats

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Nandini Manne ◽  
Ravikumar Arvapalli ◽  
Niraj Nepal ◽  
Kevin Rice ◽  
Eric Blough
Keyword(s):  
Severe Sepsis ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Hepatic Inflammation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Spleen data: Cerium oxide nanoparticles attenuate polymicrobial sepsis induced spenic damage in male Sprague Dawley rats

Data in Brief ◽  
2018 ◽  
Vol 18 ◽  
pp. 740-746 ◽  
Author(s):  
Kevin M. Rice ◽  
Venkata Vinay Kumar Bandarupalli ◽  
Nandini D.P.K. Manne ◽  
Eric R. Blough
Keyword(s):  
Cerium Oxide ◽  
Polymicrobial Sepsis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats

2015 ◽  
Vol 43 (11) ◽  
pp. e477-e489 ◽  
Author(s):  
Nandini D. P. K. Manne ◽  
Ravikumar Arvapalli ◽  
Niraj Nepal ◽  
Srinivasarao Thulluri ◽  
Vellaisamy Selvaraj ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Therapeutic Potential ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles

Biomaterials ◽  
2015 ◽  
Vol 59 ◽  
pp. 160-171 ◽  
Author(s):  
Vellaisamy Selvaraj ◽  
Niraj Nepal ◽  
Steven Rogers ◽  
Nandini D.P.K. Manne ◽  
Ravikumar Arvapalli ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Map Kinase ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis

Data in Brief ◽  
2015 ◽  
Vol 4 ◽  
pp. 105-115 ◽  
Author(s):  
Vellaisamy Selvaraj ◽  
Niraj Nepal ◽  
Steven Rogers ◽  
Nandini D.P.K. Manne ◽  
Ravikumar Arvapalli ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Map Kinase ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Safety assessment of cerium oxide nanoparticles: Combined repeated-dose toxicity with reproductive/developmental toxicity screening and biodistribution in rats

2019 ◽  
Author(s):  
Jinsoo Lee ◽  
Ji-Seong Jeong ◽  
Sang Yun Kim ◽  
Seung-Jin Lee ◽  
Young-Jun Shin ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Safety Assessment ◽  
Developmental Toxicity ◽  
Real Life ◽  
Repeated Dose ◽  
Oral Exposure ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicity Screening ◽  
Sprague Dawley

Abstract Background Cerium oxide nanoparticles (CeO 2 NPs) are widely used in various commercial applications because of their characteristic properties. CeO 2 NPs can be easily exposed to humans in real life, but the safety assessment of CeO 2 NPs has not been fully investigated. Therefore, in this study, we conducted a combined repeated-dose and reproductive/developmental toxicity screening study to investigate the potential effects on general health hazards, including reproductive/developmental functions, after repeated CeO 2 NPs oral exposure. In addition, tissues from parental animals and their pups were collected to analyze the internal accumulation of cerium. CeO 2 NPs were orally administered to Sprague-Dawley rats at doses of 0, 100, 300 and 1000 mg/kg during their pre-mating, mating, gestation and early lactation periods. Results In the general systemic and reproductive/developmental examinations, no marked toxicities were observed in any of in-life and terminal observation parameters in this study. In the biodistribution analysis, cerium was not detected in either parental or pup tissues (blood, liver, lungs and kidneys). Conclusion Repeated oral exposure of CeO 2 NPs did not induce marked toxicities affecting general systemic and reproductive/developmental functions up to the dose level of 1000 mg/kg and the CeO 2 NPs were not systemically absorbed in parental animals or their pups. This result could be used to risk assessment for human, and additional toxicity studies with CeO 2 NPs will be necessary considering various physicochemical properties and exposure probabilities of this nanoparticles.

Polyacrylic Acid Modified Cerium Oxide Nanoparticles: Synthesis and Characterization as a Peroxidase Mimic for Non-Enzymatic H2O2 Sensor

2020 ◽  
Vol 16 (5) ◽  
pp. 816-828
Author(s):  
Gurdeep Rattu ◽  
Nishtha Khansili ◽  
Prayaga M. Krishna
Keyword(s):  
Hydrogen Peroxide ◽  
Cerium Oxide ◽  
Polyacrylic Acid ◽  
Spectroscopic Analysis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Peroxidase Mimic ◽  
Ft Ir ◽  
H2o2 Sensing ◽  
Fluorescence Spectrometer

Background: Cerium oxide nanoparticles (nanoceria) are efficient free-radical scavengers due to their dual valence state and thus exhibit optical and catalytic properties. Therefore, the main purpose of this work was to understand the peroxidase mimic activity of polymer-stabilized nanoceria for enzyme-less H2O2 sensing by fluorescence spectrometer. Objective: This research revealed the development of fluorescence hydrogen peroxide nanosensor based on the peroxidase-like activity of polyacrylic acid stabilized nanoceria (PAA-CeO2 Nps). Methods: PAA-CeO2 Nps were synthesized by simple cross-linking reaction at a low temperature and characterized by XRD, SEM, Zeta potential, TGA, FT-IR and UV-VIS spectroscopic analysis. H2O2 sensing was performed by a fluorescence spectrometer. Results:: The synthesized polymer nanocomposite was characterized by XRD, SEM, TGA, FT-IR and UV-VIS spectroscopic analysis. The XRD diffraction patterns confirmed the polycrystalline nature and SEM micrograph showed nanoparticles having hexagonal symmetry and crystallite size of 32 nm. The broad peak of Ce–O bond appeared at 508 cm-1. UV-VIS measurements revealed a welldefined absorbance peak around 315 nm and an optical band-gap of 3.17 eV. As synthesized PAACeO2 Nps effectively catalysed the decomposition of hydrogen peroxide (H2O2) into hydroxyl radicals. Then terephthalic acid was oxidized by hydroxyl radical to form a highly fluorescent product. Under optimized conditions, the linear range for determination of hydrogen peroxide was 0.01 - 0.2 mM with a limit of detection (LOD) of 1.2 μM. Conclusion: The proposed method is ideally suited for the sensing of H2O2 at a low cost and this detection system enabled the sensing of analytes (sugars), which can enzymatically generate hydrogen peroxide.

Sign in / Sign up

Export Citation Format

Share Document