Functional and immunological relevance of the COOH‐terminal extension of human chorionic gonadotropin beta: implications for the WHO birth control vaccine

1993 ◽  
Vol 7 (14) ◽  
pp. 1381-1385 ◽  
Author(s):  
S Dirnhofer ◽  
R Klieber ◽  
R De Leeuw ◽  
J M Bidart ◽  
W E Merz ◽  
...  
1996 ◽  
Vol 31 (1-2) ◽  
pp. 21-36 ◽  
Author(s):  
Alison M. Jackson ◽  
Thomas Klonisch ◽  
Adrian J. Lapthorn ◽  
Peter Berger ◽  
Neil W. Isaacs ◽  
...  

2015 ◽  
Vol 444 ◽  
pp. 92-100 ◽  
Author(s):  
L. Aldaz-Carroll ◽  
S. Richon ◽  
V. Dangles-Marie ◽  
M. Cocquebert ◽  
T. Fournier ◽  
...  

1998 ◽  
Vol 5 (1) ◽  
pp. E6 ◽  
Author(s):  
Paul B. Rogers ◽  
Eliot C. Sims ◽  
Nicholas Plowman

Levels of human chorionic gonadotropin-beta (HCG-beta) are elevated in up to 43% of patients with intracranial germ cell tumors (GCTs) and are useful in the diagnosis of these tumors and the follow up of such patients. The ratio of blood HCG-beta to lumbar cerebrospinal fluid (CSF) HCG-beta in these patients at presentation has not been defined. Twenty-two patients with intracranial GCTs have been treated at St. Bartholomew's Hospital over the past 15 years. Two (17%) of 12 germinomas and seven (70%) of 10 nongerminomatous GCTs had elevated blood HCG-beta at presentation. Four cases of pineal region GCTs (one of 12 germinomas and three of 10 nongerminomatous GCTs) had paired, elevated, blood and lumbar CSF HCG-beta levels. The mean blood to CSF ratio was 1:10 (range 1.7-18.4), which is substantially lower than the ratio of 286:1 reported in systemic GCTs. The authors confirm the finding of a previous single report showing that ventricular CSF HCG-beta sampling via an accessible ventriculoperitoneal shunt reservoir may give a spuriously negative result, and they discuss the pathophysiology of the blood-brain barrier in the pineal region and the implications of the intrathecal administration of chemotherapy.


2016 ◽  
Vol 62 (09/2016) ◽  
Author(s):  
Xiaoyong Guan ◽  
Yifan Sun ◽  
Hongyu Zhang ◽  
Ka Liang ◽  
Kang Long ◽  
...  

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