Matrix metalloproteinase‐1‐mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C‐X‐C chemokine receptor 4 axis

AbstractMesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.

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O096 : Matrix metalloproteinase-10 contributes to hepatocellular carcinoma development in a novel crosstalk with stromal derived growth factor 1/C-X-C chemokine receptor 4 axis

Journal of Hepatology ◽

10.1016/s0168-8278(15)30115-x ◽

2015 ◽

Vol 62 ◽

pp. S242

Author(s):

O. Garcia-Irigoyen ◽

M.U. Latasa ◽

S. Carotti ◽

I. Uriarte ◽

M. Elizalde ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Growth Factor ◽

Matrix Metalloproteinase ◽

Chemokine Receptor ◽

Chemokine Receptor 4

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Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats

International Journal of Molecular Medicine ◽

10.3892/ijmm.2018.3516 ◽

2018 ◽

Cited By ~ 5

Author(s):

Chao Du ◽

Mingde Jiang ◽

Xiaolong Wei ◽

Jianpin Qin ◽

Hui Xu ◽

...

Keyword(s):

Bone Marrow ◽

Stem Cell ◽

Liver Fibrosis ◽

Mesenchymal Stem Cell ◽

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 1

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The Effect of Mesenchymal Stem Cell Wharton's Jelly on Matrix Metalloproteinase-1 and Interleukin-4 Levels in Osteoarthritis Rat Model

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.152 ◽

2019 ◽

Vol 7 (4) ◽

pp. 529-535 ◽

Cited By ~ 1

Author(s):

Endrinaldi Endrinaldi ◽

Eryati Darwin ◽

Nasrul Zubir ◽

Gusti Revilla

Keyword(s):

Stem Cell ◽

Mesenchymal Stem Cell ◽

Matrix Metalloproteinase ◽

Joint Disease ◽

Interleukin 4 ◽

Target Component ◽

Control Group ◽

Control Group Design ◽

Matrix Metalloproteinase 1

BACKGROUND: Osteoarthritis (OA) is generally considered a degenerative joint disease caused by biomechanical changes and the ageing process. In OA pathogenesis, the development of OA is thought to be regulated largely by excess matrix metalloproteinase (MMP), which contributes to the degradation of extracellular matrices such as MMP-1 and Interleukin-4. AIM: This study aims to prove the influence of Mesenchymal Stem Cell Wharton Jelly on decreasing MMP-1 levels and increasing IL-4 which is a specific target as a target component in cases of osteoarthritis in vivo. MATERIAL AND METHODS: This research is an experimental study with the design of Post-Test-Only Control Group Design. The sample consisted of 16 OA rats as a control group and 16 OA rats treated with MSC-WJ as a treatment group. OA induction is done by injection of monosodium iodoacetate (MIA) into the intra-articular right knee. Giving MSC-WJ is done in the third week after MIA induction. The serum MMP-1 and IL-4 levels were measured after 3 weeks treated with MSC-WJ using the ELISA method. The statistical test used is an independent t-test. The value of p < 0.05 was said to be statistically significant. RESULTS: The result showed that serum MMP-1 levels were higher in the group treated with MSC-WJ than in the control group (p < 0.05). Serum IL-4 levels were higher in the group treated with MSC-WJ than in the control group (p < 0.05). CONCLUSION: This study concluded that MSC-WJ increased MMP-1 levels and IL-4 levels in serum OA rats. MSC-WJ showed a negative effect on MMP-1 in the serum of OA rats.

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