scholarly journals Negative cooperativity across β 1 ‐adrenoceptor homodimers provides insights into the nature of the secondary low‐affinity CGP 12177 β1‐adrenoceptor binding conformation

2015 ◽  
Vol 29 (7) ◽  
pp. 2859-2871 ◽  
Author(s):  
Karolina Gherbi ◽  
Lauren T. May ◽  
Jillian G. Baker ◽  
Stephen J. Briddon ◽  
Stephen J. Hill
Keyword(s):  
Negative Cooperativity ◽  
Binding Conformation ◽  
Cgp 12177

scholarly journals Engineering the biomimetic cofactors of NMNH for cytochrome P450 BM3 based on binding conformation refinement

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 12036-12042
Author(s):  
Yao Liu ◽  
Yalong Cong ◽  
Chuanxi Zhang ◽  
Bohuan Fang ◽  
Yue Pan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rational Design ◽  
Design Strategy ◽  
Efficient Utilization ◽  
P450 Bm3 ◽  
Binding Conformation ◽  
Cytochrome P450 Bm3

A rational design strategy was proposed to improve the efficient utilization of alternative biomimetic cofactor by P450 BM3 enzyme.

scholarly journals A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.

1988 ◽  
Vol 27 (4) ◽  
pp. 368-376
Author(s):  
D Lacasa ◽  
P Mauriège ◽  
M Lafontan ◽  
M Berlan ◽  
Y Giudicelli
Keyword(s):  
Fat Cells ◽  
Beta Adrenoceptors ◽  
Cgp 12177

scholarly journals (-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.

1985 ◽  
Vol 82 (3) ◽  
pp. 925-929 ◽  
Author(s):  
H. Affolter ◽  
C. Hertel ◽  
K. Jaeggi ◽  
M. Portenier ◽  
M. Staehelin
Keyword(s):  
Rate Constants ◽  
Beta Adrenergic ◽  
Cgp 12177 ◽  
Adrenergic Antagonists

scholarly journals Negative Cooperativity in a Protein Ion Channel Revealed by Current Noise, Conductance and Selectivity Experiments

2009 ◽  
Vol 96 (3) ◽  
pp. 603a
Author(s):  
Elena García-Gimenez ◽  
Vicente M. Aguilella ◽  
Antonio Alcaraz
Keyword(s):  
Ion Channel ◽  
Current Noise ◽  
Negative Cooperativity

Effect of bupranolol on CGP 12177-induced relaxation and cAMP accumulation in the guinea pig taenia caecum

1995 ◽  
Vol 26 (8) ◽  
pp. 1791-1794 ◽  
Author(s):  
Katsuo Koike ◽  
Takahiro Horinouchi ◽  
Issei Takayanagi
Keyword(s):  
Guinea Pig ◽  
Camp Accumulation ◽  
Cgp 12177
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