scholarly journals The crystal structure of amyloid precursor‐like protein 2 E2 domain completes the amyloid precursor protein family

2019 ◽  
Vol 33 (4) ◽  
pp. 5076-5081 ◽  
Author(s):  
Laila C. Roisman ◽  
Sen Han ◽  
Mun Joo Chuei ◽  
Andrea R. Connor ◽  
Roberto Cappai
Keyword(s):  
Crystal Structure ◽  
Amyloid Precursor Protein ◽  
Protein Family ◽  
Precursor Protein

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

scholarly journals IGF-1-induced Processing of the Amyloid Precursor Protein Family Is Mediated by Different Signaling Pathways

2007 ◽  
Vol 282 (14) ◽  
pp. 10203-10209 ◽  
Author(s):  
Linda Adlerz ◽  
Sofia Holback ◽  
Gerd Multhaup ◽  
Kerstin Iverfeldt
Keyword(s):  
Amyloid Precursor Protein ◽  
Signaling Pathways ◽  
Protein Family ◽  
Precursor Protein

scholarly journals Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch

2001 ◽  
Vol 276 (38) ◽  
pp. 35235-35238 ◽  
Author(s):  
Yongjun Gu ◽  
Hiroaki Misonou ◽  
Toru Sato ◽  
Naoshi Dohmae ◽  
Koji Takio ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Family ◽  
Precursor Protein ◽  
Β Amyloid

scholarly journals Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging

2013 ◽  
Vol 8 (Suppl 1) ◽  
pp. P26
Author(s):  
Arpita Kundu ◽  
Andreas Zymny ◽  
Steffi Chang ◽  
Nelli Röhner ◽  
Donat Kögel
Keyword(s):  
Amyloid Precursor Protein ◽  
Family Members ◽  
Protein Family ◽  
Precursor Protein ◽  
Stress Signaling

scholarly journals The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation

2015 ◽  
Vol 29 (8) ◽  
pp. 785-790 ◽  
Author(s):  
Kai Xu ◽  
Olav Olsen ◽  
Dorothea Tzvetkova-Robev ◽  
Marc Tessier-Lavigne ◽  
Dimitar B. Nikolov
Keyword(s):  
Crystal Structure ◽  
Amyloid Precursor Protein ◽  
Death Receptor ◽  
Receptor Activation ◽  
Precursor Protein ◽  
Insight Into

scholarly journals Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers

2008 ◽  
Vol 124 (4) ◽  
pp. 393-398 ◽  
Author(s):  
Guo-Bo Chen ◽  
Thomas J. Payne ◽  
Xiang-Yang Lou ◽  
Jennie Z. Ma ◽  
Jun Zhu ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Binding ◽  
Nicotine Dependence ◽  
Binding Protein ◽  
Protein Family ◽  
Precursor Protein ◽  
European American

The Function of the Amyloid Precursor Protein Family

2006 ◽  
pp. 37-51 ◽  
Author(s):  
Roberto Cappai ◽  
B. Elise Needham ◽  
Giuseppe D. Ciccotosto
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Family ◽  
Precursor Protein
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