scholarly journals The role of mitochondrial oxidative stress in the metabolic alterations in diet‐induced obesity in rats

2019 ◽  
Vol 33 (11) ◽  
pp. 12060-12072 ◽  
Author(s):  
Gema Marín‐Royo ◽  
Cristina Rodríguez ◽  
Aliaume Le Pape ◽  
Raquel Jurado‐Lopez ◽  
María Luaces ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Oxidative Stress ◽  
Metabolic Alterations ◽  
Diet Induced Obesity

scholarly journals Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder

2017 ◽  
Vol Volume 13 ◽  
pp. 1633-1645 ◽  
Author(s):  
Xiaosong Bu ◽  
De Wu ◽  
Xiaomei Lu ◽  
Li Yang ◽  
Xiaoyan Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autistic Spectrum Disorder ◽  
Spectrum Disorder ◽  
Mitochondrial Oxidative Stress ◽  
Autistic Spectrum

scholarly journals Role of Olive Oil and Monounsaturated Fatty Acids in Mitochondrial Oxidative Stress and Aging

2006 ◽  
Vol 64 (10) ◽  
pp. 31-39 ◽  
Author(s):  
José L. Quiles ◽  
Gustavo Barja ◽  
Maurizio Battino ◽  
José Mataix ◽  
Vincenzo Solfrizzi
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Olive Oil ◽  
Monounsaturated Fatty Acids ◽  
Mitochondrial Oxidative Stress

Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells

2008 ◽  
Vol 320 (1-2) ◽  
pp. 185-195 ◽  
Author(s):  
Binod Kumar ◽  
Amit Kumar ◽  
B. N. Pandey ◽  
K. P. Mishra ◽  
Banasri Hazra
Keyword(s):  
Oxidative Stress ◽  
Breast Carcinoma ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Mitochondrial Oxidative Stress ◽  
Mcf 7

Mitochondrial Oxidative Stress-Induced Epigenetic Modif ications in Pancreatic Epithelial Cells

2014 ◽  
Vol 33 (2) ◽  
pp. 116-129 ◽  
Author(s):  
Pradyumna Kumar Mishra ◽  
Gorantla Venkata Raghuram ◽  
Deepika Jain ◽  
Subodh Kumar Jain ◽  
Naveen Kumar Khare ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Histone Modifications ◽  
Expression Patterns ◽  
Fragile Sites ◽  
Gene Promoters ◽  
Mitochondrial Oxidative Stress ◽  
Altered Expression ◽  
Posttranslational Histone Modifications

Emerging studies have linked prooxidative carbamate compound exposures with various human pathologies including pancreatic cancer. In these studies, our aim was to examine mitochondrial oxidative stress-mediated aberrant chromatin responses in human pancreatic ductal epithelial cells. Posttranslational histone modifications, promoter DNA methylation, and micro-RNA (miRNA) expression patterns were evaluated following induction of mitochondrial oxidative stress by N-succinimidyl N-methylcarbamate exposure. In treated cells, perturbation in mitochondrial machinery led to hypermethylation of p16 and smad4 gene promoters and downregulation of respective gene products. Posttranslational histone modifications that include hypoacetylation of acetylated histone (AcH) 3 and AcH4, hypermethylation of monomethylated histone 3 at lysine 9 and trimethylated histone 4 at lysine 20 ubiquitinated histone (uH) 2A/uH2B, and increased phosphorylation of H2AX and H3 were observed in the treated cells. Altered expression of miRNAs denoted possible location of corresponding genes at oxidatively damaged fragile sites. Collectively, our results provide a direct role of mitochondrial oxidative stress-mediated epigenetic imbalance to perturbed genomic integrity in oxygen radical-induced pancreatic injury. Further, identification and characterization of molecular switches that affect these epigenomic signatures and targets thereof will be imperative to understand the complex role of redox-regulatory network in pancreatic milieu.

scholarly journals Role of Mitochondrial Oxidative Stress in Sepsis

2018 ◽  
Vol 33 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Harsha Nagar ◽  
Shuyu Piao ◽  
Cuk-Seong Kim
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Oxidative Stress
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