scholarly journals MHC class I and II peptide homology regulates the cellular immune response

2020 ◽  
Vol 34 (6) ◽  
pp. 8082-8101
Author(s):  
Matthew M. Halpert ◽  
Vanaja Konduri ◽  
Dan Liang ◽  
Jonathan Vazquez‐Perez ◽  
Colby J. Hofferek ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Antonio J. Martín-Galiano ◽  
Francisco Díez-Fuertes ◽  
Michael J. McConnell ◽  
Daniel López

The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.


2002 ◽  
Vol 63 (6) ◽  
pp. 452-458 ◽  
Author(s):  
Corine A. van Kampen ◽  
Minke F.J. Versteeg-vd Voort Maarschalk ◽  
Janneke Langerak-Langerak ◽  
Dave L. Roelen ◽  
Frans H.J. Claas

2021 ◽  
Vol 12 ◽  
Author(s):  
Jean C. Digitale ◽  
Perri C. Callaway ◽  
Maureen Martin ◽  
George Nelson ◽  
Mathias Viard ◽  
...  

Variation within the HLA locus been shown to play an important role in the susceptibility to and outcomes of numerous infections, but its influence on immunity to P. falciparum malaria is unclear. Increasing evidence indicates that acquired immunity to P. falciparum is mediated in part by the cellular immune response, including NK cells, CD4 and CD8 T cells, and semi-invariant γδ T cells. HLA molecules expressed by these lymphocytes influence the epitopes recognized by P. falciparum-specific T cells, and class I HLA molecules also serve as ligands for inhibitory receptors including KIR. Here we assessed the relationship of HLA class I and II alleles to the risk of P. falciparum infection and symptomatic malaria in a cohort of 892 Ugandan children and adults followed prospectively via both active and passive surveillance. We identified two HLA class I alleles, HLA-B*53:01 and HLA-C*06:02, that were associated with a higher prevalence of P. falciparum infection. Notably, no class I or II HLA alleles were found to be associated with protection from P. falciparum parasitemia or symptomatic malaria. These findings suggest that class I HLA plays a role in the ability to restrict parasitemia, supporting an essential role for the cellular immune response in P. falciparum immunity. Our findings underscore the need for better tools to enable mechanistic studies of the T cell response to P. falciparum at the epitope level and suggest that further study of the role of HLA in regulating pre-erythrocytic stages of the P. falciparum life cycle is warranted.


2006 ◽  
Vol 67 (6) ◽  
pp. 424-429 ◽  
Author(s):  
Frans H.J. Claas ◽  
Dave L. Roelen ◽  
Arend Mulder ◽  
Ilias I.N. Doxiadis ◽  
Machteld Oudshoorn ◽  
...  

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  

2004 ◽  
Vol 146 (4) ◽  
pp. 159-172 ◽  
Author(s):  
D. Müller-Doblies ◽  
S. Baumann ◽  
P. Grob ◽  
A. Hülsmeier ◽  
U. Müller-Doblies ◽  
...  

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