Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern

The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.

Download Full-text

Review of "The Viral Transcription Group Determines the HLA Class I Cellular Immune Response Against Human Respiratory Syncytial Virus"

Publons reviews and discussion ◽

10.14322/publons.r113028 ◽

2015 ◽

Author(s):

Etienne Caron

Keyword(s):

Immune Response ◽

Respiratory Syncytial Virus ◽

Cellular Immune Response ◽

Hla Class I ◽

Human Respiratory Syncytial Virus ◽

Class I ◽

Viral Transcription ◽

Syncytial Virus ◽

Cellular Immune

Download Full-text

Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child

Human Immunology ◽

10.1016/s0198-8859(02)00396-8 ◽

2002 ◽

Vol 63 (6) ◽

pp. 452-458 ◽

Cited By ~ 40

Author(s):

Corine A. van Kampen ◽

Minke F.J. Versteeg-vd Voort Maarschalk ◽

Janneke Langerak-Langerak ◽

Dave L. Roelen ◽

Frans H.J. Claas

Keyword(s):

Immune Response ◽

Cellular Immune Response ◽

Hla Class I ◽

Class I ◽

Hla Class I Antigens ◽

Cellular Immune ◽

Kinetics Of

Download Full-text

HLA Alleles B53:01 and C06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda

Frontiers in Immunology ◽

10.3389/fimmu.2021.650028 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jean C. Digitale ◽

Perri C. Callaway ◽

Maureen Martin ◽

George Nelson ◽

Mathias Viard ◽

...

Keyword(s):

Immune Response ◽

T Cells ◽

Cellular Immune Response ◽

Hla Class I ◽

T Cell Response ◽

Class I ◽

Hla Alleles ◽

Symptomatic Malaria ◽

Cellular Immune ◽

Hla Molecules

Variation within the HLA locus been shown to play an important role in the susceptibility to and outcomes of numerous infections, but its influence on immunity to P. falciparum malaria is unclear. Increasing evidence indicates that acquired immunity to P. falciparum is mediated in part by the cellular immune response, including NK cells, CD4 and CD8 T cells, and semi-invariant γδ T cells. HLA molecules expressed by these lymphocytes influence the epitopes recognized by P. falciparum-specific T cells, and class I HLA molecules also serve as ligands for inhibitory receptors including KIR. Here we assessed the relationship of HLA class I and II alleles to the risk of P. falciparum infection and symptomatic malaria in a cohort of 892 Ugandan children and adults followed prospectively via both active and passive surveillance. We identified two HLA class I alleles, HLA-B*53:01 and HLA-C*06:02, that were associated with a higher prevalence of P. falciparum infection. Notably, no class I or II HLA alleles were found to be associated with protection from P. falciparum parasitemia or symptomatic malaria. These findings suggest that class I HLA plays a role in the ability to restrict parasitemia, supporting an essential role for the cellular immune response in P. falciparum immunity. Our findings underscore the need for better tools to enable mechanistic studies of the T cell response to P. falciparum at the epitope level and suggest that further study of the role of HLA in regulating pre-erythrocytic stages of the P. falciparum life cycle is warranted.

Download Full-text

The Viral Transcription Group Determines the HLA Class I Cellular Immune Response Against Human Respiratory Syncytial Virus

Molecular & Cellular Proteomics ◽

10.1074/mcp.m114.045401 ◽

2015 ◽

Vol 14 (4) ◽

pp. 893-904 ◽

Cited By ~ 9

Author(s):

Carolina Johnstone ◽

Elena Lorente ◽

Alejandro Barriga ◽

Eilon Barnea ◽

Susana Infantes ◽

...

Keyword(s):

Immune Response ◽

Respiratory Syncytial Virus ◽

Cellular Immune Response ◽

Hla Class I ◽

Human Respiratory Syncytial Virus ◽

Class I ◽

Viral Transcription ◽

Syncytial Virus ◽

Cellular Immune

Download Full-text

Differential Immunogenicity of HLA Class I Alloantigens for the Humoral versus the Cellular Immune Response: “Towards Tailor-Made HLA Mismatching”

Human Immunology ◽

10.1016/j.humimm.2006.03.004 ◽

2006 ◽

Vol 67 (6) ◽

pp. 424-429 ◽

Cited By ~ 12

Author(s):

Frans H.J. Claas ◽

Dave L. Roelen ◽

Arend Mulder ◽

Ilias I.N. Doxiadis ◽

Machteld Oudshoorn ◽

...

Keyword(s):

Immune Response ◽

Cellular Immune Response ◽

Hla Class I ◽

Class I ◽

Cellular Immune

Download Full-text

MHC class I and II peptide homology regulates the cellular immune response

The FASEB Journal ◽

10.1096/fj.201903002r ◽

2020 ◽

Vol 34 (6) ◽

pp. 8082-8101

Author(s):

Matthew M. Halpert ◽

Vanaja Konduri ◽

Dan Liang ◽

Jonathan Vazquez‐Perez ◽

Colby J. Hofferek ◽

...

Keyword(s):

Immune Response ◽

Mhc Class I ◽

Cellular Immune Response ◽

Class I ◽

Cellular Immune

Download Full-text

The Evaluation of Cellular Immunity to Avian Viral Diseases: Methods, Applications, and Challenges

Frontiers in Microbiology ◽

10.3389/fmicb.2021.794514 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiaoli Hao ◽

Fan Zhang ◽

Yi Yang ◽

Shaobin Shang

Keyword(s):

Immune Response ◽

T Cell ◽

Viral Infection ◽

T Cell Activation ◽

Cellular Immunity ◽

Cellular Immune Response ◽

Viral Diseases ◽

Immune Protection ◽

Cell Immunity ◽

Cellular Immune

Cellular immune responses play critical roles in the control of viral infection. However, the immune protection against avian viral diseases (AVDs), a major challenge to poultry industry, is yet mainly evaluated by measuring humoral immune response though antibody-independent immune protection was increasingly evident in the development of vaccines against some of these diseases. The evaluation of cellular immune response to avian viral infection has long been neglected due to limited reagents and methods. Recently, with the availability of more immunological reagents and validated approaches, the evaluation of cellular immunity has become feasible and necessary for AVD. Herein, we reviewed the methods used for evaluating T cell immunity in chickens following infection or vaccination, which are involved in the definition of different cellular subset, the analysis of T cell activation, proliferation and cytokine secretion, and in vitro culture of antigen-presenting cells (APC) and T cells. The pros and cons of each method were discussed, and potential future directions to enhance the studies of avian cellular immunity were suggested. The methodological improvement and standardization in analyzing cellular immune response in birds after viral infection or vaccination would facilitate the dissection of mechanism of immune protection and the development of novel vaccines and therapeutics against AVD.

Download Full-text