scholarly journals The Possible Immunosuppressive Effects of Perioperative Blood Transfusion in Cancer Patients

1988 ◽  
Vol 68 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Julien F. Biebuyck ◽  
Paula A. Schriemer ◽  
David E. Longnecker ◽  
Paul D. Mintz
Keyword(s):  
Blood Transfusion ◽  
Cancer Patients ◽  
Perioperative Blood Transfusion

scholarly journals Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy

2019 ◽  
Vol 8 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Zheng Liu ◽  
Jia-Jun Luo ◽  
Kevin Y Pei ◽  
Sajid A Khan ◽  
Xiao-Xu Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Blood Transfusion ◽  
Cancer Patients ◽  
Death Rate ◽  
Joint Effect ◽  
Severe Anemia ◽  
Joint Effects ◽  
Mild Anemia ◽  
Operative Complications ◽  
Perioperative Blood Transfusion

Abstract Background Both pre-operative anemia and perioperative (intra- and/or post-operative) blood transfusion have been reported to increase post-operative complications in patients with colon cancer undergoing colectomy. However, their joint effect has not been investigated. The purpose of this study was to evaluate the joint effect of pre-operative anemia and perioperative blood transfusion on the post-operative outcome of colon-cancer patients after colectomy. Methods We identified patients from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database 2006–2016 who underwent colectomy for colon cancer. Multivariate logistic regression analysis was employed to assess the independent and joint effects of anemia and blood transfusion on patient outcomes. Results A total of 35,863 patients—18,936 (52.8%) with left-side colon cancer (LCC) and 16,927 (47.2%) with right-side colon cancer (RCC)—were identified. RCC patients were more likely to have mild anemia (62.7%) and severe anemia (2.9%) than LCC patients (40.2% mild anemia and 1.4% severe anemia). A total of 2,661 (7.4%) of all patients (1,079 [5.7%] with LCC and 1,582 [9.3%] with RCC) received a perioperative blood transfusion. Overall, the occurrence rates of complications were comparable between LCC and RCC patients (odds ratio [OR] = 1.01; 95% confidence interval [CI] = 0.95–1.07; P = 0.750). There were significant joint effects of anemia and transfusion on complications and the 30-day death rate (P for interaction: 0.010). Patients without anemia who received a transfusion had a higher risk of any complications (LCC, OR = 3.51; 95% CI = 2.55–4.85; P < 0.001; RCC, OR = 3.74; 95% CI = 2.50–5.59; P < 0.001), minor complications (LCC, OR = 2.54; 95% CI = 1.63–3.97; P < 0.001; RCC, OR = 2.27; 95% CI = 1.24–4.15; P = 0.008), and major complications (LCC, OR = 5.31; 95% CI = 3.68–7.64; P < 0.001; RCC, OR = 5.64; 95% CI = 3.61–8.79; P < 0.001), and had an increased 30-day death rate (LCC, OR = 6.97; 95% CI = 3.07–15.80; P < 0.001; RCC, OR = 4.91; 95% CI = 1.88–12.85; P = 0.001) than patients without anemia who did not receive a transfusion. Conclusions Pre-operative anemia and perioperative transfusion are associated with an increased risk of post-operative complications and increased death rate in colon-cancer patients undergoing colectomy.

Impact of Anesthetics, Analgesics, and Perioperative Blood Transfusion in Pediatric Cancer Patients

2019 ◽  
Vol 129 (6) ◽  
pp. 1653-1665 ◽  
Author(s):  
Juan P. Cata ◽  
Pascal Owusu-Agyemang ◽  
Ravish Kapoor ◽  
Per-Arne Lonnqvist
Keyword(s):  
Blood Transfusion ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
Perioperative Blood Transfusion

The Impact of Perioperative Blood Transfusion on Survival of Bladder Cancer Patients Submitted to Radical Cystectomy: Role of Anemia Status

2016 ◽  
Vol 2 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Marco Moschini ◽  
Marco Bianchi ◽  
Giorgio Gandaglia ◽  
Vito Cucchiara ◽  
Stefano Luzzago ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Blood Transfusion ◽  
Cancer Patients ◽  
Radical Cystectomy ◽  
The Impact ◽  
Perioperative Blood Transfusion

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

2015 ◽  
Vol 32 (6) ◽  
pp. 445-453 ◽  
Author(s):  
Keisuke Kosumi ◽  
Yoshifumi Baba ◽  
Kazuto Harada ◽  
Naoya Yoshida ◽  
Masayuki Watanabe ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Blood Transfusion ◽  
Cancer Patients ◽  
Gastrointestinal Cancer ◽  
Disease Free Survival ◽  
Upper Gastrointestinal Cancer ◽  
Age At Surgery ◽  
Gastric Cancer Patients ◽  
Upper Gastrointestinal ◽  
Perioperative Blood Transfusion

Aims: It is demonstrated that older animals have significantly weaker responses to new alloantigen stimulation than young animals, but the effect on prognosis of perioperative blood transfusion in relation to patient age is unknown. This study is retrospective review to investigate the relationship between perioperative blood transfusion, age at surgery, and clinical outcome in upper gastrointestinal cancer patients. Methods: We analyzed data of 526 upper gastrointestinal cancer patients who underwent curative resection from 2005 to 2010. Results: In esophageal cancer patients, patients with blood transfusion experienced significantly shorter overall survival (OS; univariate HR 2.50, p = 0.0006) and disease-free survival (DFS; univariate HR 1.71, p = 0.016) than patients without. Similar results were observed in gastric cancer patients (OS; univariate HR 3.35, p = 0.0001 and DFS; univariate HR = 3.18, p < 0.0001). Furthermore perioperative blood transfusion may be an independent prognostic factor in esophageal cancer patients (multivariate HR = 2.07, p = 0.026). Interestingly, age at surgery significantly affected the influence of blood transfusion on patient outcome in esophageal cancer patients (p for interaction = 0.022). Conclusion: The negative effect of perioperative blood transfusion was particularly evident among younger patients with esophageal cancer.

scholarly journals Malnutrition-Related Factors Increased the Risk of Anastomotic Leak for Rectal Cancer Patients Undergoing Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hao Xu ◽  
Fanmin Kong
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
Blood Transfusion ◽  
Cancer Patients ◽  
Nutritional Support ◽  
Perioperative Period ◽  
Tumor Stage ◽  
Rectal Cancer Surgery ◽  
Increased Risk ◽  
Perioperative Blood Transfusion

Objective. To study the possible risk factors and related prediction indexes of anastomotic leakage (AL) in patients with rectal cancer during the perioperative period and to provide effective indexes for predicting whether AL will occur in postoperative patients with rectal cancer and whether early nutritional support is needed. Background. AL after rectal cancer surgery is a common and serious complication. Many of the risk factors for AL have been confirmed. Nevertheless, the evidence of the effect of perioperative malnutrition on AL is still insufficient. This article will make a further study on this point. Methods. We collected perioperative clinical data from 382 patients with rectal cancer who underwent surgery from September 2015 to May 2017. After 1 month of follow-up, relevant risk factor data were collected and analyzed. Results. Data analysis showed that the incidence of AL was 14.65%. In single factor analysis, patients with high score of NRS-2002, high score of PG-SGA, diabetes, perioperative blood transfusion, postoperative diarrhea, later tumor stage, high score of ASA, low postoperative albumin, and rectal cancer patients with tumor close to the anus may led to AL. Multivariate analysis revealed that low postoperative albumin (p=0.044), tumor close to the anus (p=0.004), diabetes (p=0.003), perioperative blood transfusion (p<0.001), diarrhea (p=0.005), later tumor stage, and high score of PG-SGA (p<0.001) were the independent risk factors for postoperative AL. Conclusions. AL in rectal cancer operation is a common postoperative complication. Patients with diabetes or high PG-SGA score or low perioperative albumin will have increased risk factors of AL, which should be paid enough attention in the perioperative period and nutritional support should be provided as soon as possible. Patients who have incomplete intestinal obstruction but can make effective intestinal preparation or who receive neoadjuvant chemotherapy have no increased risk of AL.

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