Effects of Sevoflurane on Cardiac Action Potential and Delayed Rectifier Potassium Channel: An Ionic Basis for Anesthetic-Induced Changes in QT Interval

2002 ◽  
Vol 96 (Sup 2) ◽  
pp. A625
Author(s):  
Akihiro Suzuki ◽  
Kei Aizawa ◽  
Wai-Meng Kwok ◽  
Zeljko J. Bosnjak
Keyword(s):  
Action Potential ◽  
Potassium Channel ◽  
Qt Interval ◽  
Cardiac Action Potential ◽  
Delayed Rectifier ◽  
Cardiac Action ◽  
Delayed Rectifier Potassium Channel ◽  
Induced Changes ◽  
Ionic Basis ◽  
Rectifier Potassium Channel

Cardiomyocyte slowly activating delayed rectifier potassium channel: regulation by exercise and β-adrenergic signaling

2020 ◽  
Vol 128 (5) ◽  
pp. 1177-1185 ◽  
Author(s):  
Xinrui Wang ◽  
Robert H. Fitts
Keyword(s):  
Exercise Training ◽  
Action Potential ◽  
Potassium Channel ◽  
Delayed Rectifier ◽  
Adrenergic Signaling ◽  
Channel Current ◽  
Channel Regulation ◽  
Anchoring Protein ◽  
Delayed Rectifier Potassium Channel ◽  
Rectifier Potassium Channel

Results demonstrate that exercise training (TRN) downregulates ventricular IKs channel current and the channel’s responsiveness to β-agonist factors mediated by TRN-induced decline in channel subunits KCNQ1 and KCNE1 and the A-kinase anchoring protein yotiao. The reduced IKs current helps explain the TRN-induced prolongation of the action potential in basal conditions and, coupled with previously reported upregulation of the KATP channel, results in a more efficient heart that is better able to respond to beat-by-beat changes in metabolism.

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