In vitro synergistic effects of some novel Cu(ll) complexes in combination with epirubicin and mitomycin C against HeLa-S3 cervical cancer cell line

1996 ◽  
Vol 7 (4) ◽  
pp. 469-475 ◽  
Author(s):  
G D Geromichalos ◽  
G A Katsoulos ◽  
C C Hadjikostas ◽  
A H Kortsaris ◽  
D A Kyriakidis
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Mitomycin C ◽  
Cancer Cell ◽  
Synergistic Effects ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Hela S3

scholarly journals A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4214
Author(s):  
Jenna M. Len ◽  
Noor Hussein ◽  
Saloni Malla ◽  
Kyle Mcintosh ◽  
Rahul Patidar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Mitotic Catastrophe ◽  
Cervical Cancer Cell Line ◽  
Intrinsic Apoptosis ◽  
Caspase 7

In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores in the cervical cancer cell line, OV2008. The compound, DML6 was selective and significantly decreased the proliferation of OV2008 and HeLa cells in sub-micromolar concentrations, compared to prostate, lung, colon, breast or human embryonic kidney cell line (HEK293). DML6, at 5 μM, arrested the OV2008 cells in the G2 phase. Furthermore, DML6, at 5 μM, increased the levels of reactive oxygen species and induced a collapse in the mitochondrial membrane potential, compared to OV2008 cells incubated with a vehicle. DML6, at 5 μM, induced intrinsic apoptosis by significantly (1) increasing the levels of the pro-apoptotic proteins, Bak and Bax, and (2) decreasing the levels of l the anti-apoptotic protein, Bcl-2, compared to cell incubated with a vehicle. Furthermore, DML6, at 5 and 20 μM, induced the cleavage of caspase-9, followed by subsequent cleavage of the executioner caspases, caspase-3 and caspase-7, which produced OV2008 cell death. Overall, our data suggest that DML6 is an apoptosis-inducing compound that should undergo further evaluation as a potential treatment for cervical cancer.

scholarly journals Retraction: Tetraarsenic Oxide-mediated Apoptosis in a Cervical Cancer Cell Line, SiHa

2007 ◽  
Vol 39 (1) ◽  
pp. 48
Author(s):  
Jeong Kim ◽  
Su-Mi Bae ◽  
Dae-Seog Lim ◽  
Sun-Young Kwak ◽  
Chang-Ki Lee ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line
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