Population pharmacokinetics of low-dose paclitaxel in patients with brain tumors

2003 ◽  
Vol 14 (6) ◽  
pp. 417-422 ◽  
Author(s):  
Georg Hempel ◽  
Christian Rübe ◽  
Christina Mosler ◽  
Marlies Wienstroer ◽  
Alexandra Wagner-Bohn ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Population Pharmacokinetics ◽  
Low Dose

Interstitial Irradiation of Brain Tumors

Neurosurgery ◽  
1981 ◽  
Vol 9 (6) ◽  
pp. 741-750 ◽  
Author(s):  
Mark Bernstein ◽  
Philip H. Gutin
Keyword(s):  
Brain Tumors ◽  
Low Dose ◽  
Treatment Approach ◽  
Radiation Necrosis ◽  
Benign Tumors ◽  
Normal Brain ◽  
Interstitial Irradiation ◽  
Dose Rates ◽  
Conventional Dose ◽  
History Of

Abstract As an adjuvant to surgery, radiation therapy has consistently proven to be the most successful form of treatment for primary and secondary malignant brain tumors and possibly for inoperable benign tumors. Because the risk of radiation necrosis of normal brain limits the amount of radiation that can be given by external beam therapy at conventional dose rates, interstitial radiation of brain tumors is a logical alternative treatment approach. We discuss the radiobiological advantages of low dose rate irradiation and intratumoral placement of sources that make interstitial irradiation an attractive treatment for brain tumors and review the history of clinical brachytherapy for intracranial neoplasia.

scholarly journals Low dose ionizing radiation induced acoustic neuroma: A putative link?

2012 ◽  
Vol 01 (01) ◽  
pp. 078-079
Author(s):  
Sachin Borkar ◽  
Deepak Agrawal
Keyword(s):  
Ionizing Radiation ◽  
Brain Tumors ◽  
Acoustic Neuroma ◽  
Cumulative Dose ◽  
Low Dose ◽  
High Dose ◽  
Atomic Reactor ◽  
Radiation Induced

Abstract Although exposure to high dose ionizing radiation (following therapeutic radiotherapy) has been incriminated in the pathogenesis of many brain tumors, exposure to chronic low dose ionizing radiation has not yet been shown to be associated with tumorigenesis. The authors report a case of a 50-year-old atomic reactor scientist who received a cumulative dose of 78.9 mSv over a 10-year period and was detected to have an acoustic neuroma another 15 years later. Although there is no proof that exposure to ionizing radiation was the cause for the development of the acoustic neuroma, this case highlights the need for extended follow-up periods following exposure to low dose ionizing radiation.

scholarly journals Multi-joint steroid-induced avascular necrosis in a malignant brain tumor patient

CNS Oncology ◽  
2021 ◽  
Author(s):  
Jessica M Lewis-Gonzalez ◽  
Mallika P Patel ◽  
Katherine B Peters
Keyword(s):  
Case Report ◽  
Brain Tumors ◽  
Avascular Necrosis ◽  
Symptom Management ◽  
Low Dose ◽  
Low Grade ◽  
Tumor Patient ◽  
Frequent Use ◽  
Short Course ◽  
High Doses

Avascular necrosis (AVN) is a rare but serious adverse event associated with the use of corticosteroids for long durations or at high doses. This case report describes a 47-year-old female patient with low-grade astrocytoma who was initiated on low-dose dexamethasone for symptom management. The patient developed joint pain 1 year after steroid exposure, then was found to have AVN of the hip followed by multiple other joints. This case report highlights the extent to which AVN can occur in patients with brain tumors following a short course of low-dose corticosteroids. Careful evaluation of and monitoring for the development of AVN should occur frequently in patients with brain tumors given the frequent use of corticosteroids for symptom management in this population.

LOW-DOSE RATE TELECOBALT-THERAPY AS A BOOST AGAINST BRAIN-TUMORS

1994 ◽  
Author(s):  
S YAMADA ◽  
Y TAKAI ◽  
K NEMOTO ◽  
Y OGAWA ◽  
A HOSHI ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Dose Rate ◽  
Low Dose ◽  
Low Dose Rate

Additive value of 320-section low-dose dynamic volume CT in relation to 3-T MRI for the preoperative evaluation of brain tumors

2016 ◽  
Vol 34 (10) ◽  
pp. 691-699
Author(s):  
Eri Hayashida ◽  
Toshinori Hirai ◽  
Hideo Nakamura ◽  
Masafumi Kidoh ◽  
Minako Azuma ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Low Dose ◽  
Preoperative Evaluation ◽  
Volume Ct ◽  
Dynamic Volume Ct

scholarly journals Population pharmacokinetics of intranasally administered low dose melatonin

2002 ◽  
Vol 53 (5) ◽  
pp. 543P-544P
Author(s):  
E. Helfrich ◽  
C. Neef ◽  
F. W. H. M. Merkus
Keyword(s):  
Population Pharmacokinetics ◽  
Low Dose
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