MEIBOMIAN GLAND AND TEAR FILM LIPIDS: STRUCTURE, FUNCTION AND CONTROL.

Cornea ◽  
2000 ◽  
Vol 19 (Supplement 2) ◽  
pp. S104
Author(s):  
James P. McCulley ◽  
Ward Shine
Keyword(s):  
Structure Function ◽  
Tear Film ◽  
Meibomian Gland ◽  
And Control

The study of dry eye and meibomian glands in psoriasis

2021 ◽  
pp. 112067212110070
Author(s):  
Ahmad Reza Taheri ◽  
Elahe Allahyari ◽  
Mostafa Zeinaly ◽  
Malihe Nikandish
Keyword(s):  
Dry Eye ◽  
Structural Parameters ◽  
Tear Film ◽  
Meibomian Gland ◽  
Medical Sciences ◽  
Schirmer Test ◽  
Ocular Surface Disease Index ◽  
Meibomian Glands ◽  
And Gender ◽  
And Control

Background: To investigate aqueous and lipid layers of the tear film as well as meibomian gland structure by meibography in psoriatic patients in the Iranian population. Methods: This case-control study was conducted on 31 psoriasis patients and 31 controls in Birjand University of Medical Sciences in 2018. The sampling method was available from the date of approval of the proposal in the Ethics Committee until it reached the sample size. After entering the study, patients were examined individually with a slit lamp. Then, Ocular Surface Disease Index (OSDI) score assessment, Schirmer test 1, lacrimal measurement with SM tube, tear break-up time (TBUT), and meibomian glands imaging by SBM Sistemi were done. Finally, the obtained data were entered into SPSS 15 software and analyzed at a significant level of less than 0.05. Results: The two groups were matched according to age and gender ( p = 0.39 and p = 0.80; respectively). With the exception of the SM Tube score, the mean of all tear film and meibomian glands functional and structural parameters including Schirmer test 1, TBUT, and meibography were significantly different between patients and control groups. Moreover, the proportion of abnormal OSDI (OSDI ⩾ 13) and the dry eye was significantly higher in psoriasis patients. Conclusions: Psoriasis is associated with dry eye as well as meibomian glands atrophy and dysfunction.

Meibomian Gland & Tear Film Lipids: Structure, Function & Control

2005 ◽  
Vol 3 ◽  
pp. S11
Author(s):  
James McCulley ◽  
Hiroto Obata ◽  
John Tiffany
Keyword(s):  
Structure Function ◽  
Tear Film ◽  
Meibomian Gland

Impression cytology and meibomian glands in conjunctivochalasis

2021 ◽  
pp. 112067212110087
Author(s):  
Ersin Muhafiz ◽  
Erdinç Bozkurt ◽  
Remzi Erten
Keyword(s):  
Dropout Rate ◽  
Meibomian Gland ◽  
Control Group ◽  
Study Group ◽  
Impression Cytology ◽  
Schirmer Test ◽  
Significant Difference ◽  
Meibomian Glands ◽  
And Control ◽  
Margin Cytology

Purpose: To evaluate the tear parameters, meibomian glands and lid margin and tarsal conjunctival impression cytology in patients with conjunctivochalasis (CCH). Methods: The study included 57 patients diagnosed with CCH and 35 healthy volunteers. Tear break-up time (TBUT) was measured and Schirmer test was performed. Meibomian gland morphologies, dropout rates, and meiboscores were evaluated using meibography. Finally, impression cytology samples were taken by pressing the impression filters on the lower lid margin and lower tarsal conjunctiva. The samples were evaluated according to the Nelson grading system. Results: Schirmer test was longer and TBUT was shorter in the study group ( p = 0.035 and p < 0.001, respectively). The median of meibomian gland dropout rate was 33.45% (Interquartile range [IQR]; 23.17%–49.75%) and 18.80% (IQR; 12.35%–26.50%) in the study and control groups, respectively ( p < 0.001). There was no significant difference in terms of lid-margin cytology between the two groups ( p = 0.481). In tarsal conjunctiva cytology, the median value of Nelson grade of the study group was 2 (IQR; 1–2) and that of the control group was 1 (IQR; 1–2) ( p = 0.040). When Nelson grade-2 and above was accepted as the pathological limit, it was found that 27.5% of the study group and 15.2% of the control group showed pathological findings ( p = 0.204). Conclusions: In patients with CCH, damage occurs in the tarsal conjunctiva with the effects of redundant conjunctival folds. In these patients, atrophy occurs in the meibomian glands and tear stability is impaired. Therefore, CCH should not be overlooked in clinical practice.

Eyelid Tattooing Induces Meibomian Gland Loss and Tear Film Instability

Cornea ◽  
2015 ◽  
Vol 34 (7) ◽  
pp. 750-755 ◽  
Author(s):  
Young Bok Lee ◽  
Jin Joo Kim ◽  
Joon Young Hyon ◽  
Won Ryang Wee ◽  
Young Joo Shin
Keyword(s):  
Tear Film ◽  
Meibomian Gland ◽  
Film Instability

scholarly journals Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Hyeonha Hwang ◽  
Hee-Jae Jeon ◽  
Kin Choong Yow ◽  
Ho Sik Hwang ◽  
EuiHeon Chung
Keyword(s):  
Quantitative Analysis ◽  
Layer Thickness ◽  
Tear Film ◽  
Meibomian Gland ◽  
Lipid Layer

scholarly journals Effects of a New Eyelid Shampoo on Lid Hygiene and Eyelash Length in Patients with Meibomian Gland Dysfunction: A Comparative Open Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Asuka Kobayashi ◽  
Takeshi Ide ◽  
Teruki Fukumoto ◽  
Emiko Miki ◽  
Kazuo Tsubota ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Controlled Study ◽  
Subjective Symptoms ◽  
Eyelid Margin ◽  
Before And After ◽  
And Function ◽  
Lid Hygiene

Purpose. Meibomian gland dysfunction (MGD) can lead to abnormalities in the composition and function of tear film, resulting in dry eye. Eyelid hygiene is a key to management of MGD. We tested a novel eyelid shampoo (Eye Shampoo Long, ESL) for its ability to maintain lid hygiene. This shampoo is nonirritating and can potentially lengthen eyelashes. This study was aimed to evaluate the efficacy of ESL in the treatment of MGD and its effects on eyelash length. Methods. Ten patients with MGD and 10 healthy subjects without MGD applied ESL twice daily for 8 weeks. Patients were examined for lid margin and dry eye before and after the trial. Subjective symptoms were evaluated. Eyelash length was measured at baseline and at the end of the trial. Results. In the MGD group, significant improvements were observed in subjective symptoms obstruction of the meibomian orifice, secretion of meibum, eyelashes contamination, eyelid margin foam, and SPK. Eyelash length became significantly longer. Conclusions. Maintaining eyelid hygiene using ESL improved the eyelid margins and symptoms of dry eye in MGD patients and increased eyelash length. These findings are promising and warrant confirmation in a larger randomized controlled study.

scholarly journals Diagnostic Test Efficacy of Meibomian Gland Morphology and Function

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jiaxin Xiao ◽  
Muhammed Yasin Adil ◽  
Jonatan Olafsson ◽  
Xiangjun Chen ◽  
Øygunn A. Utheim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Tear Film ◽  
Cross Sectional Study ◽  
Meibomian Gland ◽  
Clinical Parameters ◽  
Cross Sectional ◽  
And Function ◽  
Breakup Time

AbstractMeibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD severity. This retrospective, cross-sectional study included 100 MGD patients and 20 controls. The patients were classified into dry eye severity level (DESL) 1–4 based on symptoms and clinical parameters including tear-film breakup time, ocular staining and Schirmer I. The gland loss, length, thickness, density and distortion were analyzed. We compared the morphology between patients and controls; examined their correlations to meibum expressibility, quality, and DESL. Relative to controls, the gland thickness, density and distortion were elevated in patients (p < 0.001 for all tests). The area under the receiver operating characteristic curve was 0.98 (95% confidence interval [CI], 0.96–1.0) for gland loss, and 0.96 (CI 0.91–1.0) for gland distortion, with a cutoff value of six distorted glands yielding a sensitivity of 93% and specificity of 97% for MGD diagnosis. The gland distortion was negatively correlated to the meibum expressibility (r = −0.53; p < 0.001) and DESL (r = −0.22, p = 0.018). In conclusion, evaluation of meibomian gland loss and distortion are valuable complementary clinical parameters to assess MGD status.

Tear Film and Ocular Surface Changes after Closure of the Meibomian Gland Orifices in the Rabbit

Ophthalmology ◽  
1989 ◽  
Vol 96 (8) ◽  
pp. 1180-1186 ◽  
Author(s):  
Jeffrey P. Gilbard ◽  
Scott R. Rossi ◽  
Kathleen Gray Heyda
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Surface Changes
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