Case Study: Long-Term Potentiation of Neuroleptics with Transdermal Nicotine in Tourette's Syndrome

Author(s):  
ARCHIE A. SILVER ◽  
R DOUGLAS SHYTLE ◽  
MARY K. PHILIPP ◽  
PAUL R. SANBERG
Author(s):  
Jyh-Woei Lin

Ginkgo biloba has been used in traditional medicine, by which memory in the brain could be improved. In this study, a dementia patient has taken Ginkgo biloba during the time period of a year as a case study. He has taken a pill with 665 mg for a year from 08 November 2018 to 08 November 2019 (Taiwan Standard Time, TST). Later, the brain waves were largely different. However, he could only know his family name, the long term memory (LTM) could showed only a small recovery. The treatment outcome has been limited. Focusing on synapses in the brain can be a good way of interpreting the results. For future research, some new medications containing Ginkgo biloba can be devised for keeping a normal converting long-term potentiation (LTP) for healthy persons and for resisting dementia. The new proposal contributes to this study. Ginkgo biloba should be necessary as a pharmaceutical ingredient.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Grace Edwards ◽  
Anna Berestova ◽  
Lorella Battelli

AbstractStable sensory perception is achieved through balanced excitatory-inhibitory interactions of lateralized sensory processing. In real world experience, sensory processing is rarely equal across lateralized processing regions, resulting in continuous rebalancing. Using lateralized attention as a case study, we predicted rebalancing lateralized processing following prolonged spatial attention imbalance could cause a gain in attention in the opposite direction. In neurotypical human adults, we isolated covert attention to one visual field with a 30-min attention-demanding task and found an increase in attention in the opposite visual field after manipulation. We suggest a gain in lateralized attention in the previously unattended visual field is due to an overshoot through attention rebalancing. The offline post-manipulation effect is suggestive of long-term potentiation affecting behavior. Our finding of visual field specific attention increase could be critical for the development of clinical rehabilitation for patients with a unilateral lesion and lateralized attention deficits. This proof-of-concept study initiates the examination of overshoot following the release of imbalance in other lateralized control and sensory domains, important in our basic understanding of lateralized processing.


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