Is a History of Tonsillectomy Associated With a Decreased Risk of Helicobacter pylori Infection?

Abstract Background There have been few studies in the English literature regarding verrucous gastritis (VG). The present study investigated the clinical and endoscopic features of verrucous antral gastritis, especially focusing on Helicobacter pylori infection, nutrition, and gastric atrophy. Methods We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative groups. VG was subdivided into classical and numerous types based on the number and distribution of verrucous lesions. Demographic, clinical, and endoscopic data including body mass index (BMI), serum albumin and cholesterol, gastric atrophy, reflux oesophagitis, Barrett’s oesophagus, and H. pylori status were collected. Univariate and multivariable analyses were performed to identify factors associated with VG. Results We analysed the data of 621 patients undergoing routine endoscopy and found that VG (n = 352) was significantly associated with increased BMI (1.12 [1.05–1.18], P < 0.01), reflux esophagitis (1.96 [1.10–3.28], P < 0.01), and H. pylori negativity with or without a history of eradication (9.94 [6.00–16.47] and 6.12 [3.51–10.68], P < 0.001, respectively). Numerous-type (n = 163) VG was associated with both closed- and open-type gastric atrophy (9.9 [4.04–21.37] and 8.10 [3.41–19.24], P < 0.001, respectively). There were no statistical differences between groups regarding age, sex, total cholesterol, albumin, and bile-colored gastric juice. Conclusions Verrucous antral gastritis was related to increased BMI, reflux esophagitis, and H. pylori negativity. Numerous-type verrucous lesions were associated with gastric atrophy. These indicate that VG may be a physiological phenomenon due to high gastric acidity, mechanical overload, and vulnerability of background mucosa.

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Helicobacter pylori Infection and Family History of Gastric Cancer Decrease Expression of FHIT Tumor Suppressor Gene in Gastric Mucosa of Dyspeptic Patients

Helicobacter ◽

10.1111/j.1523-5378.2009.00715.x ◽

2009 ◽

Vol 14 (5) ◽

pp. 478-486 ◽

Cited By ~ 11

Author(s):

Krystyna Stec-Michalska ◽

Lukasz Peczek ◽

Blazej Michalski ◽

Maria Wisniewska-Jarosinska ◽

Agnieszka Krakowiak ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Family History ◽

Gastric Mucosa ◽

Tumor Suppressor ◽

Tumor Suppressor Gene ◽

Suppressor Gene ◽

Helicobacter Pylori Infection ◽

History Of

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Parental history of gastric or duodenal ulcer and prevalence of Helicobacter pylori infection in preschool children: population based study

BMJ ◽

10.1136/bmj.316.7132.665 ◽

1998 ◽

Vol 316 (7132) ◽

pp. 665-665 ◽

Cited By ~ 27

Author(s):

H. Brenner ◽

D. Rothenbacher ◽

G. Bode ◽

G. Adler

Keyword(s):

Duodenal Ulcer ◽

Helicobacter Pylori ◽

Preschool Children ◽

Population Based ◽

Helicobacter Pylori Infection ◽

Parental History ◽

Population Based Study ◽

History Of

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Natural history of Helicobacter pylori infection

Digestive and Liver Disease ◽

10.1016/j.dld.2008.02.035 ◽

2008 ◽

Vol 40 (7) ◽

pp. 490-496 ◽

Cited By ~ 71

Author(s):

P. Correa ◽

M.B. Piazuelo

Keyword(s):

Helicobacter Pylori ◽

Natural History ◽

Helicobacter Pylori Infection ◽

History Of

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Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection

Experimental Biology and Medicine ◽

10.1177/1535370218819423 ◽

2018 ◽

Vol 243 (15-16) ◽

pp. 1161-1164

Author(s):

Maria Pina Dore ◽

Giovanni Mario Pes ◽

Alessandra Errigo ◽

Alessandra Manca ◽

Giuseppe Realdi

Keyword(s):

Helicobacter Pylori ◽

Animal Models ◽

Gastric Mucosa ◽

Natural History ◽

Tissue Transglutaminase ◽

Helicobacter Pylori Infection ◽

Human Gastric Mucosa ◽

Antral Mucosa ◽

History Of ◽

H Pylori

Tissue transglutaminase (t-TG) is a multifunctional protein involved in the healing of gastric erosions and ulcers in animal models. The aim of this study was to measure gastric t-TG activity in patients with dyspepsia according to Helicobacter pylori infection and cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) subtype status. Patients undergoing upper endoscopy not taking any medications were enrolled. Tissue-TG activity was determined in homogenates of antral specimens using a radiometric assay and was expressed in pmol/mg. The cagA and vacA genotypes were determined by PCR amplification using gene-specific oligoprimers. Data from 46 patients were available (17 of them were positive for H. pylori). Antral t-TG activity was significantly increased in H. pylori positive patients compared to H. pylori negative patients (6437 ± 3691 vs. 3773 ± 1530 pmol/mg; P = 0.001) according to Mann–Whitney U test. Patients with H. pylori negative gastritis had higher t-TG activity than patients with normal gastric mucosa. The specimens infected with cagA positive strains (72%) displayed greater t-TG activity than cagA negative samples (7358 ± 4318 vs. 4895 ± 1062 pmol/mg; P = 0.237). Similarly, t-TG activity was higher in H. pylori vacA s1/m1 strains vs. vacA s1/m2 (7429 vs. 5045 pmol/mg; P = 0.744), and vacA s1/m1 vs. s2/m2 (7429 vs. 4489 pmol/mg; P = 0.651) but the results were not significant. No differences were found between histology, endoscopy features and t-TG activity. These results show that t-TG activity is significantly greater in gastritis associated with H. pylori infection, suggesting that this enzyme is induced by inflammation and may have an important role in the natural history of human gastritis. Impact statement Tissue transglutaminase (t-TG) is unique among TG enzymes because of its additional role in several physiological and pathological activities, including inflammation, fibrosis, and wound healing. The presence of t-TG has previously been described in the intestine of human and animal models, yet studies on t-TG activity in human gastric mucosa are missing. Helicobacter pylori infection is the major cause of gastritis and peptic ulcers. For the first time, our results show that t-TG activity was significantly higher in antral specimens of patients with chronic active gastritis associated with H. pylori infection compared to H. pylori negative chronic gastritis and normal antral mucosa. These findings suggest that t-TG has a role in the natural history of human gastritis, which requires further investigation but may be an avenue for new therapeutic options.

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The role of Helicobacter pylori infection on the natural history of HCV and the impact on the response to therapy

Gastroenterology ◽

10.1016/s0016-5085(03)81953-4 ◽

2003 ◽

Vol 124 (4) ◽

pp. A385-A386

Author(s):

Maher Azzouz ◽

Christopher J. Christensen ◽

Gagan Sood

Keyword(s):

Helicobacter Pylori ◽

Natural History ◽

Response To Therapy ◽

Helicobacter Pylori Infection ◽

History Of ◽

The Impact

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Duodenal ulcer during the period of twenty years after discovering of Helicobacter pylori: Experience gained at our centre

Medicinski pregled ◽

10.2298/mpns1004258j ◽

2010 ◽

Vol 63 (3-4) ◽

pp. 258-261

Author(s):

Ivan Jovanovic ◽

Petar Djuric ◽

Tamara Alempijevic ◽

Aleksandra Sokic-Milutinovic ◽

Miodrag Krstic ◽

...

Keyword(s):

Duodenal Ulcer ◽

Helicobacter Pylori ◽

Clinicopathological Features ◽

Helicobacter Pylori Infection ◽

Helicobacter Pylori Eradication ◽

Duodenal Ulcer Disease ◽

Ulcer Disease ◽

Dyspeptic Symptoms ◽

History Of ◽

Second Period

Introduction It is now well established that Helicobacter pylori eradication can significantly modify the natural history of peptic ulcer disease. The aim of this study was to assess the frequency of duodenal ulcer among patients endoscopically examined for dyspeptic symptoms and analyse the disease time trend during two ten-year long distinctive retrospective periods (1987-2006). Material and methods Data were obtained through retrospective analysis of outpatients upper endoscopy reports. Full reports were available for 58 515 patients which were analysed for selected clinicopathological features in two clearly defined time periods. The first one, starting from 1987 to 1996 in which Helicobacter pylori infection was not assessed and treated accordingly and the second period from 1997 to 2006 during which the presence of Helicobacter pylori infection in certain diseases was routinely assessed and then treated with PPI based triple therapy. Results Syptoms of dyspepsia appeared to be approximately the same as the indication for endoscopy in both periods (65.1%:63.3%). The frequency of duodenal ulcer disease significantly decreased in the second period of analysis (t=14761; p<0.01). In both periods men had more often duodenal ulcer comparing to women (??= 218.53, p<0.01; ??=21.7, p<0.01). During the second examined period the number of women who had duodenal ulcer significantly increased comparing to the first ten-year period (??=17232; p<0.01). Conclusion The test-and-treat strategy and the implementation of consensus on diagnosis and treatment of Helicobacter pylori infection resulted in a significant decrease in the frequency of duodenal ulcer disease.

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