THE CHANGE IN PULSE WAVE VELOCITY OVER THE CARDIAC CYCLE IS INDEPENDENTLY ASSOCIATED WITH LEFT VENTRICULAR MASS INDEX IN MIDDLE-AGED HEALTHY SUBJECTS

2011 ◽  
Vol 29 ◽  
pp. e38
Author(s):  
E. Hermeling ◽  
S. Vermeersch ◽  
E. Rietzschel ◽  
M. De Buyzere ◽  
T. Gillebert ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Left Ventricular Mass Index ◽  
Cardiac Cycle ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Middle Aged ◽  
Ventricular Mass Index

A new technique for study of impact of arterial elasticity on left ventricular mass in rats

1996 ◽  
Vol 270 (3) ◽  
pp. H981-H987
Author(s):  
F. Amin ◽  
N. Niederhoffer ◽  
R. Tatchum-Talom ◽  
T. Makki ◽  
J. Guillou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Elastic Modulus ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
New Technique ◽  
Arterial Elasticity ◽  
Ventricular Mass

We investigated possible links between left ventricular mass and central arterial elasticity in the adult spontaneously hypertensive rat (SHR) and in a subgroup of SHR in which blood pressure was normalized by chronic antihypertensive drug treatment; results were compared with those of age-matched normotensive Wistar-Kyoto rats. Two indexes of arterial elasticity, based on the measurement of aortic pressure pulse wave velocity, were used. First, the slope relating carotidofemoral pulse wave velocity to blood pressure in the phenylephrine-infused pithed preparation was used as a pressure-independent index of wall elasticity. Second, to account for hypertension- and treatment-induced aortic remodeling, elastic modulus was determined from the pulse wave velocity recorded when blood pressure reached that measured in awake animals before anesthesia and pithing, together with values for wall thickness and lumen diameter evaluated by histomorphometric analysis after in situ fixation at the same pressure. In control SHR, regression analysis of variance revealed significant correlations between left ventricular mass and both wave velocity/pressure slope and elastic modulus. Chronic antihypertensive treatment normalized all three parameters. In conclusion, this new technique provides experimental evidence of a link between left ventricular mass and central arterial elasticity.

Effect of Aerobic versus Resistance Exercise on Pulse Wave Velocity, Intima Media Thickness and Left Ventricular Mass in Obese Adolescents

2015 ◽  
Vol 27 (4) ◽  
pp. 494-502 ◽  
Author(s):  
Katy Horner ◽  
Emma Barinas-Mitchell ◽  
Curt DeGroff ◽  
Jennifer L. Kuk ◽  
Stacey Drant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Obese Adolescents ◽  
Media Thickness

A cardiovascular comorbidity in obese adolescents is increased aortic pulse wave velocity (aPWV), carotid intima-media thickness (cIMT) and left ventricular mass (LVM). We investigated in obese adolescents 1) the risk factors associated with aPWV, cIMT and LVM, and 2) the effects of aerobic (AE) versus resistance (RE) exercise alone (without calorie restriction) on aPWV, cIMT, LVM index (LVMI) and cardiometabolic risk factors. Eighty-one obese adolescents (12–18 yrs, BMI ≥95th percentile) were randomized to 3 months of AE (n = 30), RE (n = 27) or a control group (n = 24). Outcome measures included aPWV, cIMT, LVMI, body composition, cardiorespiratory fitness (CRF), blood pressure (BP) and lipids. At baseline, the strongest correlates of aPWV were body weight (r = .31) and diastolic BP (r = .28); of cIMT were body weight (r=0.26) and CRF (r=-0.25); and of LVMI was CRF (r=0.32) after adjusting for sex and race (p < .05 for all). Despite significant reductions in total fat and improvements in CRF in the AE and RE groups, aPWV, cIMT, LVMI, BP, lipids and body weight did not change as compared with controls (p > .05 for all). Interventions of longer duration or together with weight loss may be required to improve these early biomarkers of CVD in obese adolescents.

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