WIDESPREAD NEUROFIBRILLARY TANGLES IN A RETARDED PATIENT WITH PROGRESSIVE CONGENITAL HYDROCEPHALUS

1986 ◽  
Vol 45 (3) ◽  
pp. 367 ◽  
Author(s):  
K. J. Fan ◽  
G. Pezeshkpour
Keyword(s):  
Neurofibrillary Tangles ◽  
Congenital Hydrocephalus ◽  
Retarded Patient

Liquid crystalline ordering of paired helical filaments in neurofibrillary tangles of Alzheimer's disease

1986 ◽  
Vol 44 ◽  
pp. 348-349
Author(s):  
D.F. Clapin ◽  
V.J.A. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangles ◽  
Liquid Crystalline ◽  
Amyloid Fibrils ◽  
Geometric Analysis ◽  
Paired Helical Filaments ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Regular Spacing

Alzheimer's disease is characterized by the accumulation of abnormal filamentous proteins. The most important of these are amyloid fibrils and paired helical filaments (PHF). PHF are located intraneuronally forming bundles called neurofibrillary tangles. The designation of these structures as "tangles" is appropriate at the light microscopic level. However, localized domains within individual tangles appear to demonstrate a regular spacing which may indicate a liquid crystalline phase. The purpose of this paper is to present a statistical geometric analysis of PHF packing.

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

1985 ◽  
Vol 43 ◽  
pp. 726-729
Author(s):  
K.S. Kosik ◽  
L.K. Duffy ◽  
S. Bakalis ◽  
C. Abraham ◽  
D.J. Selkoe
Keyword(s):  
Monoclonal Antibodies ◽  
Alzheimer Disease ◽  
Human Brain ◽  
Neurofibrillary Tangles ◽  
Morphological Analysis ◽  
High Specificity ◽  
Cytoskeletal Proteins ◽  
Neuritic Plaque ◽  
Protein Chemistry ◽  
Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer

1996 ◽  
Vol 22 (1) ◽  
pp. 12-16 ◽  
Author(s):  
J. F. Geddes ◽  
G. H. Vowles ◽  
S. F. D. Robinson ◽  
J. C. Sutcliffe
Keyword(s):  
Neurofibrillary Tangles ◽  
Alzheimer Type

A CASE OF FETAL DYSTOCIA DUE TO CONGENITAL HYDROCEPHALUS WITH MICROMELIA IN A PUG AND ITS MANAGEMENT

2019 ◽  
Vol 11 (1) ◽  
pp. 058
Author(s):  
M.S. Bawaskar ◽  
S.K. Sahatpure ◽  
S.S. Bawaskar ◽  
G.S. Nalkande ◽  
V.U. Takle ◽  
...  
Keyword(s):  
Congenital Hydrocephalus
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