Ki-67/MIB-1 LABELING INDEX PREDICTS PATIENT SURVIVAL IN LOW GRADE AND ANAPLASTIC ASTROCYTOMAS

Object In residual nonfunctioning pituitary adenomas, reliable prognostic parameters indicating probability of tumor progression are needed. The Ki 67 expression/MIB-1 labeling index (LI) is considered to be a promising candidate factor. The aim in the present study was to analyze the clinical usefulness of MIB-1 LI for prognosis of tumor progression. Methods The authors studied a cohort of 92 patients with nonfunctioning pituitary adenomas. Based on sequential postoperative MR images, patients were classified as tumor free (51 patients) or as harboring residual tumor (41 individuals). The residual tumor group was further subdivided in groups with stable residual tumors (14 patients) or progressive residual tumors (27 patients). The MIB-1 LI was assessed in tumor specimens obtained in all patients, and statistical comparisons of MIB-1 LI of the various subgroups were performed. Results . The authors found no significant difference of MIB-1 LI in the residual tumor group compared with the tumor-free group. However, MIB-1 LI was significantly higher in the progressive residual tumor group, compared with the stable residual tumor group. Additionally, the time period to second surgery was significantly shorter in residual adenomas showing an MIB-1 LI > 3%. Conclusions The data indicate that MIB-1 LI in nonfunctioning pituitary adenomas is a clinically useful prognostic parameter indicating probability of progression of postoperative tumor remnants. The MIB-1 LI may be helpful in decisions of postoperative disease management (for example, frequency of radiographic intervals, planning for reoperation, radiotherapy, and/or radiosurgery).

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Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma

Journal of Neurosurgery ◽

10.3171/2020.10.jns202881 ◽

2021 ◽

pp. 1-7

Author(s):

Sadahiro Kaneko ◽

Eric Suero Molina ◽

Peter Sporns ◽

Stephanie Schipmann ◽

David Black ◽

...

Keyword(s):

Real Time ◽

Aminolevulinic Acid ◽

Protoporphyrin Ix ◽

Low Grade Glioma ◽

Low Grade ◽

Gadolinium Contrast ◽

Ki 67 ◽

Fet Pet ◽

Kinetics Of ◽

Mib 1

OBJECTIVE 5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection. However, the value of 5-ALA–induced fluorescence in low-grade glioma (LGG) is unclear. Time dependency and time kinetics have not yet been investigated. The purpose of this study was to investigate real-time kinetics of protoporphyrin IX (PpIX) in LGG based on hyperspectral fluorescence-based measurements and identify factors that predict fluorescence. METHODS Patients with grade II gliomas and imaging from which HGGs could not be completely ruled out received 5-ALA at 20 mg/kg body weight 4 hours prior to surgery. Fluorescence intensity (FI) and PpIX concentration (CPpIX) were measured in tumor tissue utilizing a hyperspectral camera. Apparent diffusion coefficient (ADC)–based tumor cell density, Ki-67/MIB-1 index, chromosomal 1p/19q codeletion, and 18F-fluoroethyl-l-tyrosine (18F-FET) PET values and their role for predicting fluorescence were evaluated. RESULTS Eighty-one biopsies from 25 patients were included. Tissues with fluorescence demonstrated FI and CPpIX maxima between 7 and 8 hours after administration. When visible fluorescence was observed, peaks of FI and CPpIX were observed within this 7- to 8-hour time frame, regardless of any MRI gadolinium contrast enhancement. Gadolinium enhancement (p = 0.008), Ki-67/MIB-1 index (p < 0.001), 18F-FET PET uptake ratio (p = 0.004), and ADC-based tumor cellularity (p = 0.017) significantly differed between fluorescing and nonfluorescing tissue, but not 1p/19q codeletions. Logistic regression demonstrated that 18F-FET PET uptake and Ki-67/MIB-1 index were independently related to fluorescence. CONCLUSIONS This study reports a fluorescence-based assessment of CPpIX in human LGG tissues related to 18F-FET PET uptake and Ki-67/MIB-1. As in HGGs, fluorescence in LGGs peaked between 7 and 8 hours after 5-ALA application, which has consequences for the timing of administration.

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MIB-1 labeling index, Ki-67, is an indicator of invasive intraductal papillary mucinous neoplasm

Molecular and Clinical Oncology ◽

10.3892/mco.2016.908 ◽

2016 ◽

Vol 5 (2) ◽

pp. 317-322 ◽

Cited By ~ 2

Author(s):

Tatsuo Shimura ◽

Yasuhide Kofunato ◽

Ryo Okada ◽

Rei Yashima ◽

Koji Okada ◽

...

Keyword(s):

Intraductal Papillary Mucinous Neoplasm ◽

Labeling Index ◽

Ki 67 ◽

Mucinous Neoplasm ◽

Mib 1

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Predictors of invasive breast cancer or DCIS recurrence in estrogen receptor positive (ER+) and estrogen receptor negative (ER-) ductal carcinoma in situ (DCIS) patients with and without associated invasive carcinoma (IC)

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e11523 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e11523-e11523 ◽

Cited By ~ 1

Author(s):

J. Picarsic ◽

A. Brufsky ◽

A. Onisko ◽

M. Chivukula

Keyword(s):

Estrogen Receptor ◽

Biological Markers ◽

Hormone Receptors ◽

Invasive Carcinoma ◽

Ductal Carcinoma ◽

Response To Therapy ◽

Proliferation Index ◽

Low Grade ◽

Ki 67 ◽

Mib 1

e11523 Background: DCIS is a heterogeneous pre-invasive carcinoma with a spectrum of clinical behavior. Patients with ER+ IC have better outcomes compared to ER- patients. FOXA1 and GATA 3 family of transcription factors have been shown to be associated with hormone receptors (ER and PR) and other variables of good prognosis with better overall and relapse-free survival rate. The specific aim of this study is to analyze the expression of these novel biological markers: FOXA1, GATA-3, with recognized markers: MIB-1(Ki-67) and HER2 /neu in DCIS patients with/without associated IC. Methods: Sixty-nine (69) cases of DCIS [(fifty two (52) cases in ER+; seventeen (17) in ER-] were retrieved from our Pathology database. The expressions of the biological markers are analyzed by using a panel of immunohistochemical stains. FOXA1, GATA 3, ER, PR are nuclear stains, a cumulative “H score” is derived based on proportionality (PS) and intensity scores (IS). A proliferation index (PI) is calculated for MIB-1 (Ki67) nuclear stain (low <10%, moderate 11–25%, high 26–50%, very high>50%). Her2/neu is scored as per guidelines for HercepTest (0, or 1+ =negative, 2+ =weakly positive, 3+ =strongly positive). Results: DCIS is categorized into low grade (LG) (nuclear grade 1 and 2), high grade (HG) (grade 3). In the HGDCIS (n=48), four (4) cases had IC after a mean of 7.75 years; three cases of recurrent DCIS after a mean 6 years. No recurrent IC or DCIS is seen in the LGDCIS (n=21) group. The results are shown in the Table . Conclusions: (1) Decreased expression of GATA 3 is observed in HGDCIS ER- group may be a contributor to higher recurrence observed in this group (14%) versus (0%) in ER+ group. (2) A strong expression of FOXA, GATA3, low Ki-67 index, absent Her 2 expression are characteristically seen in our ER+ DCIS group, as previously described in IC. 3. Comparing the response to therapy and outcome in the ER+ and ER- groups is on going. [Table: see text] No significant financial relationships to disclose.

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Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography

Journal of Neurosurgery ◽

10.3171/2010.11.jns10553 ◽

2011 ◽

Vol 114 (6) ◽

pp. 1640-1647 ◽

Cited By ~ 46

Author(s):

Natsuki Shinozaki ◽

Yoshio Uchino ◽

Kyosan Yoshikawa ◽

Tomoo Matsutani ◽

Azusa Hasegawa ◽

...

Keyword(s):

Mr Imaging ◽

Histological Type ◽

Labeling Index ◽

Low Grade ◽

Astrocytic Tumors ◽

Ki 67 ◽

Oligodendroglial Tumors ◽

Grade Ii ◽

The Mean ◽

Grade Iii

Object The diagnostic usefulness of 11C-methionine PET scans in gliomas is still controversial. The authors investigated the clinical significance of 11C-methionine PET findings in preoperative diagnosis of histological type and grade. Methods The tissue uptake of 11C-methionine was assessed using PET in 70 patients with histologically confirmed intracerebral gliomas. The ratio of maximum standard uptake values in tumor areas to the mean standard uptake values in the contralateral normal brain tissue (tumor/normal tissue [T/N] ratio) was calculated and correlated with tumor type, histological grade, contrast enhancement on MR imaging, Ki 67 labeling index, and 1p/19q status. Results The T/N ratio was significantly increased as tumor grade advanced in astrocytic tumors (WHO Grade II vs Grade III, p = 0.0011; Grade III vs Grade IV, p = 0.0007). Among Grade II gliomas, the mean T/N ratio was significantly higher in oligodendroglial tumors than in diffuse astrocytomas (DAs) (p < 0.0001). All T/N ratios for oligodendroglial tumors were ≥ 1.46, and those for DA were consistently < 1.46, with the exception of 2 cases of gemistocytic astrocytoma. The Ki 67 labeling index significantly correlated with T/N ratio in astrocytic tumors, but not in oligodendrogliomas. Oligodendroglial tumors without 1p/19q deletion had a significantly higher T/N ratio than those with the codeletion. In combination with Gd-enhanced MR imaging, 67% of nonenhanced tumors with a T/N ratio of ≥ 1.46 were proved to be Grade II oligodendrogliomas. Conclusions These results clearly show that 11C-methionine PET T/N ratios in Grade II oligodendrogliomas were higher than those in DAs independently of their proliferative activity. This information contributes to preoperative differential diagnoses of histological type, especially in suspected low-grade gliomas.

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Increased MIB-1/Ki-67 Labeling Index as a Predictor of an Aggressive Course in a Case of Prolactinoma

Hormone Research in Paediatrics ◽

10.1159/000075375 ◽

2004 ◽

Vol 61 (3) ◽

pp. 111-116 ◽

Cited By ~ 6

Author(s):

Taiba Zornitzki ◽

Hilla Knobler ◽

Dvora Nass ◽

Moshe Hadani ◽

Ilan Shimon

Keyword(s):

Labeling Index ◽

Ki 67 ◽

Mib 1

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The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas

Pathology & Oncology Research ◽

10.1007/bf02893360 ◽

2006 ◽

Vol 12 (3) ◽

pp. 143-147 ◽

Cited By ~ 101

Author(s):

Anne Linn Johannessen ◽

Sverre Helge Torp

Keyword(s):

Labeling Index ◽

Clinical Value ◽

Ki 67 ◽

Human Astrocytomas ◽

Mib 1

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Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples

The Journal of Pathology ◽

10.1002/path.1711740407 ◽

1994 ◽

Vol 174 (4) ◽

pp. 275-282 ◽

Cited By ~ 102

Author(s):

Pauli K. Sallinen ◽

Hannu K. Haapasalo ◽

Tapio Visakorpi ◽

Pauli T. Helén ◽

Immo S. Rantala ◽

...

Keyword(s):

Patient Survival ◽

S Phase ◽

Phase Fraction ◽

Ki 67 ◽

Mib 1

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Histogram analysis in predicting the grade and histological subtype of meningiomas based on diffusion kurtosis imaging

Acta Radiologica ◽

10.1177/0284185119898656 ◽

2020 ◽

Vol 61 (9) ◽

pp. 1228-1239

Author(s):

Xiaodan Chen ◽

Lin Lin ◽

Jie Wu ◽

Guang Yang ◽

Tianjin Zhong ◽

...

Keyword(s):

Pearson Correlation ◽

Mean Diffusivity ◽

Labeling Index ◽

Histogram Analysis ◽

Diffusion Kurtosis Imaging ◽

Low Grade ◽

High Grade ◽

Ki 67 ◽

Diffusion Kurtosis ◽

Median Maximum

Background Presurgical grading is particularly important for selecting the best therapeutic strategy for meningioma patients. Purpose To investigate the value of histogram analysis of diffusion kurtosis imaging (DKI) maps in the differentiation of grades and histological subtypes of meningiomas. Material and Methods A total of 172 patients with histopathologically proven meningiomas underwent preoperative magnetic resonance imaging (MRI) and were classified into low-grade and high-grade groups. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) histograms were generated based on solid components of the whole tumor. The following parameters of each histogram were obtained: 10th, 25th, 75th, and 90th percentiles, mean, median, maximum, minimum, and kurtosis, skewness, and variance. Comparisons of different grades and subtypes were made by Mann–Whitney U test, Kruskal–Wallis test, ROC curves analysis, and multiple logistic regression. Pearson correlation was used to evaluate correlations between histogram parameters and the Ki-67 labeling index. Results Significantly higher maximum, skewness, and variance of MD, mean, median, maximum, variance, 10th, 25th, 75th, and 90th percentiles of MK were found in high-grade than low-grade meningiomas (all P < 0.05). DKI histogram parameters differentiated 7/10 pairs of subtype pairs. The 90th percentile of MK yielded the highest AUC of 0.870 and was the only independent indicator for grading meningiomas. Various DKI histogram parameters were correlated with the Ki-67 labeling index ( P < 0.05). Conclusion The histogram analysis of DKI is useful for differentiating meningioma grades and subtypes. The 90th percentile of MK may serve as an optimal parameter for predicting the grade of meningiomas.

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