Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material

AbstractBackground:Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology.Aim: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF).Materials and methods:An 18 year-old male with expulsion of tooth 11 and partial fracture of the alveolar ridge was treated with augmentation of the alveolar ridge using bone graft material, injectable platelet–rich-fibrin(i-PRF) and advanced platelet-rich-fibrin (A-PRF). Clinical results were reviewed 4 months after the augmentation and a dental implant was placed.Results:The postoperative period was uneventful. The control CBCT scan showed good organization of new bone allowing placement of a dental implant.Conclusion:The successful clinical and radiographic results of the case suggest that using A-PRF and i-PRF can be beneficial for bone augmentation of the alveolar ridge before implant placement.

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Evaluation of Ground Cortical Autograft as a Bone Graft Material in a New Canine Bilateral Segmental Long Bone Defect Model

Journal of Orthopaedic Trauma ◽

10.1097/00005131-199601000-00005 ◽

1996 ◽

Vol 10 (1) ◽

pp. 28-36 ◽

Cited By ~ 23

Author(s):

Kenneth D. Johnson ◽

Adrian August ◽

Marcus F. Sciadini ◽

Cathy Smith

Keyword(s):

Bone Graft ◽

Bone Defect ◽

Long Bone ◽

Graft Material ◽

Defect Model ◽

Bone Graft Material ◽

Long Bone Defect

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Sinus Augmentation With Platelet-Rich Fibrin in Combination With Bovine Bone Graft Versus Bovine Bone Graft in Combination With Collagen Membrane

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-13-00129 ◽

2015 ◽

Vol 41 (5) ◽

pp. 586-595 ◽

Cited By ~ 15

Author(s):

Nilufer Bolukbasi ◽

Selim Ersanlı ◽

Nurullah Keklikoglu ◽

Cansu Basegmez ◽

Tayfun Ozdemir

Keyword(s):

Bone Graft ◽

Test Group ◽

Control Group ◽

Collagen Membrane ◽

Bovine Bone ◽

Graft Material ◽

Sinus Augmentation ◽

Platelet Rich Fibrin ◽

Bone Graft Material ◽

Sinus Floor

The purpose of this study was to compare the efficacy between the use of bovine bone graft material and platelet-rich fibrin (PRF) mixture (test group) and bovine bone graft material and collagen membrane combination (control group) in 2-stage maxillary sinus augmentation. According to specific inclusion/exclusion criteria, patients treated between 2008 and 2012 were selected. Panoramic radiographs were used for radiologic assessments. To evaluate the relationship between sinus-graft height and each implant, the bone level (BL) was divided by implant length (IL). To evaluate the change in the height of grafted sinus, the grafted sinus floor above the lowest part of the original sinus height (GSH) was divided by the original sinus height (OSH). Samples taken during implant surgery were used for histologic and histomorphometric analyses. Twenty-five patients, 32 augmentation surgeries, and 66 one-stage implants were included in the study. No implant loss or complication was observed in either group. There were no statistical differences according to new bone formation (P = .61) and biomaterial remnant (P = .87). During the evaluation period, the test group showed statistically less change in the BL/IL ratio (P = .022). The difference of GSH/OSH ratio was found to be insignificant between groups (P = .093). It was observed that the grafted sinus covering the implant apex and sinus floor was above the original sinus height in both groups. It may be concluded from this study that both combinations can be successfully used for sinus augmentation. Further studies evaluating different graft materials and PRF combinations in the early phases of healing would be beneficial.

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Comparative evaluation of bioactive glass bone graft material with platelet rich fibrin and bioactive glass bone graft material alone for the treatment of periodontal intrabony defects: a clinical and radiographic study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20162281 ◽

2016 ◽

pp. 3288-3294 ◽

Cited By ~ 1

Author(s):

Prashant Ashawan ◽

R. Zade

Keyword(s):

Bioactive Glass ◽

Bone Graft ◽

Comparative Evaluation ◽

Graft Material ◽

Radiographic Study ◽

Intrabony Defects ◽

Platelet Rich Fibrin ◽

Bone Graft Material

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Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

BioMed Research International ◽

10.1155/2019/3295756 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 3

Author(s):

Yiping Liu ◽

Xiaolin Sun ◽

Jize Yu ◽

Jia Wang ◽

Peisong Zhai ◽

...

Keyword(s):

Bone Graft ◽

Bone Regeneration ◽

Ridge Preservation ◽

Graft Material ◽

Platelet Rich Fibrin ◽

Bone Graft Material ◽

Alveolar Ridge Preservation ◽

Autologous Platelet Concentrate ◽

New Type

Platelet-rich fibrin (PRF) is an autologous platelet concentrate that consists of cytokines, platelets, leukocytes, and circulating stem cells. It has been considered to be effective in bone regeneration and is mainly used for oral and maxillofacial bone. Although currently the use of PRF is thought to support alveolar ridge preservation, there is a lack of evidence regarding the application of PRF in osteogenesis. In this paper, we will provide examples of PRF application, and we will also summarize different measures to improve the properties of PRF for achieving better osteogenesis. The effect of PRF as a bone graft material on osteogenesis based on laboratory investigations, animal tests, and clinical evaluations is first reviewed here. In vitro, PRF was able to stimulate cell proliferation, differentiation, migration, mineralization, and osteogenesis-related gene expression. Preclinical and clinical trials suggested that PRF alone may have a limited effect. To enlighten researchers, modified PRF graft materials are further reviewed, including PRF combined with other bone graft materials, PRF combined with drugs, and a new-type PRF. Finally, we will summarize the common shortcomings in the application of PRF that probably lead to application failure. Future scientists should avoid or solve these problems to achieve better regeneration.

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