BIRTH ASPHYXIA ALTERS GASTRIC EMPTYING TIME AND GASTRIC ELECTRICAL ACTIVITY IN TERM AND PRETERM NEONATES

Background: We aimed to evaluate gastric volume changes during intermittent milk feeds (IMF) and continuous milk feeds (CMF) in very premature neonates (VPN), with gastric residual volume (GRV) based on antral cross-sectional area (ACSA) measurements and to examine if there were differences in GRV between the two feeding methods. Methods: A randomized prospective clinical trial with crossover design was conducted in 31 preterm neonates (gestational age < 30 weeks). Gastric volume was assessed twice in each neonate (during IMF and CMF feeding), at 7 specific time points during a 2-h observation period by measuring ACSA changes via the ultrasound (U/S) method. Results: There was a significantly different pattern of gastric volume changes between the two feeding methods. GRV, expressed as the median percentage of ACSA measurement at 120 min relative to the higher ACSA measurement during IMF, was found to be 3% (range 0–25%) for IMF and 50% (range 15–80%) for CMF. Neonates fed with IMF had a shorter mean gastric emptying time compared to those fed with CMF (p = 0.0032). No signs of feeding intolerance were recorded in either group during the period of observation. Conclusions: Our results showed that gastric volume changes and gastric emptying time in VPN, based on ACSA measurement changes, depend on the milk feeding method. No gastrointestinal complications/adverse events were noted with GRV up to 80% with CMF.

Download Full-text

Caffeine and Gastric Emptying Time in Very Preterm Neonates

Journal of Clinical Medicine ◽

10.3390/jcm9061676 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1676

Author(s):

Antonios K. Gounaris ◽

Ioanna N. Grivea ◽

Maria Baltogianni ◽

Eleni Gounari ◽

George Antonogeorgos ◽

...

Keyword(s):

Gastric Emptying ◽

Preterm Neonates ◽

Control Group ◽

Cross Sectional ◽

Very Preterm ◽

Caffeine Treatment ◽

Study Results ◽

Significant Difference ◽

Gastric Emptying Time ◽

Emptying Time

Background: Caffeine has been commonly used for prevention and treatment of apnea-related symptoms in premature infants. However, its side effects have not been thoroughly studied. We investigated whether caffeine affects gastric motility in very-preterm (VP) neonates. Methods: The study is a randomized crossover clinical trial. Twenty-two neonates with mean birth weight (BW) (standard deviation—SD) 1077 (229) g and mean gestational age (GA) (SD) 28.6 (2.1) weeks were recruited. Each neonate had its gastric emptying time checked twice with ultrasound assessment of changes in antral cross sectional area (ACSA). All neonates were sequentially allocated to the caffeine group (A) and the control group (B). Complications from the gastrointestinal tract were documented throughout the study. Results: Statistically significant difference was found with regards to the gastric emptying time [median, (range)] between caffeine and control group (p = 0.040). Additionally, in the neonates with BW 1000–1500 g and GA ≥ 28 weeks, the gastric emptying time (minutes) was significantly longer during caffeine treatment [44.5 (36–68.2)] and [40 (34.5–66.5)] respectively, as compared to the gastric emptying time during no caffeine treatment [27 (24.2–30)] (p = 0.002) and [27 (24.5–30)] (p = 0.001). The incidence of gastrointestinal (GI) complications was significantly greater in neonates receiving caffeine [6 (27.%)] as compared with those without caffeine treatment [1 (4.6%)] (p = 0.039). Conclusions: During caffeine treatment, a significantly delayed gastric emptying time was noted in all study neonates, especially in these with BW 1000–1500 g and those with GA ≥ 28 weeks. Further larger studies are necessary in order to confirm this interesting finding.

Download Full-text

Randomised controlled trial of cisapride in preterm neonates for gastric emptying time

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/fn.81.2.f159a ◽

1999 ◽

Vol 81 (2) ◽

pp. F159-F159

Author(s):

A K DEORARI ◽

P S REDDY ◽

V K PAUL ◽

C S BAL

Keyword(s):

Gastric Emptying ◽

Randomised Controlled Trial ◽

Controlled Trial ◽

Preterm Neonates ◽

Gastric Emptying Time ◽

Randomised Controlled ◽

Emptying Time

Download Full-text

A modified sonographic technique for assessment of gastric emptying of liquid

Acta Radiologica ◽

10.1080/j.1600-0455.2003.00055.x ◽

2003 ◽

Vol 44 (3) ◽

pp. 340-342 ◽

Cited By ~ 4

Author(s):

J. F. Pedersen

Keyword(s):

Gastric Emptying ◽

Repeated Measurements ◽

Intraindividual Variation ◽

Ultrasound Technique ◽

Liquid Meal ◽

Ultrasound Monitoring ◽

Gastric Emptying Time ◽

The Mean ◽

Antral Area ◽

Emptying Time

Purpose: Ultrasound scanning is replacing scintigraphy in studies of gastric emptying of liquid, but both have considerable day-to-day variability. This study describes a modified ultrasound technique for assessing gastric emptying of liquid, and evaluates the inter- and intraindividual variation in emptying time. Material and Methods: On different days, each of 12 healthy volunteers had meals of 350 ml broth. The antral area was measured at sonography 5 times before the meal as a baseline, and every 1–4 min after the meal. The time until the antral area had decreased to 150% of baseline (T150) was determined and used as surrogate expression of gastric emptying time. Results: The mean T150 for a broth meal was 12.6 min (range 5–21) and 13.5 min (6–23) (first and second meal, respectively). The standard deviation of the differences between the 12 pairs of repeated measurements was 3.1 min and the coefficient of variation was 24%. Conclusion: Ultrasound monitoring of antral size after a liquid meal is a well suited method for assessing gastric emptying of liquid.

Download Full-text