Screening by Anti-Endomysium Antibody for Celiac Disease in Diabetic Children and Adolescents in Austria

Objective: To evaluate the prevalence of autoimmune thyroid disease (AITD) in diabetic children in south Punjab. Methods: This was an observational cross sectional study from Jan 2019 to Dec 2019 in the outpatient diabetic clinic of the department of pediatric endocrinology at Children Hospital and The Institute of Child Health Multan. A total of 161 consecutive patients of both genders with TIDM were enrolled in this study after taking informed consent. Blood samples for Thyroid functions testes including thyroid stimulating hormone (TSH), free thyroxin (fT4), Thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (TG-Ab) and glycosylated hemoglobin (HbA1C) level were sent. Results: Among diabetic children males were 83 (51.6%). Age range was 2-15 years. Mean age and standard deviation was 9.7± 4.3. TPO-Ab was positive in 34 patients (21.1%) and TG-Ab in 27 patients (16.7%), whereas both antibodies were positive in 17 patients (10.5%). Six patients (3.7%) had evidence of subclinical hypothyroidism, 8 patients (4.9%) had overt hypothyroidism and 1 patient (0.62%) had hyperthyroidism Conclusion: The prevalence of AITD among children and adolescents with type 1 diabetes mellitus was 21.1% in our study. Hypothyroidism was more prevalent in these children compared to hyperthyroidism. All diabetic children should be screened for AITD. Thyroid functions should be checked where TPO antibody is positive. Keywords: Autoimmune thyroid disease, anti thyroid peroxidase antibody, anti thyroglobulin Continuous...

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Ultrasonographic evaluation of the functional bladder capacity after spontaneous and stress micturition in diabetic children and adolescents and in a control group

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(00)83480-3 ◽

2000 ◽

Vol 70 ◽

pp. A140-A140

Author(s):

A.F. Camareos ◽

J.C. Castro ◽

E.M. Goulart ◽

M. Carneiro

Keyword(s):

Children And Adolescents ◽

Bladder Capacity ◽

Control Group ◽

Diabetic Children

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Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

Canadian Journal of Gastroenterology ◽

10.1155/2000/847807 ◽

2000 ◽

Vol 14 (11) ◽

pp. 919-921 ◽

Cited By ~ 31

Author(s):

Helen Rachel Gillett ◽

Hugh James Freeman

Keyword(s):

Celiac Disease ◽

Small Bowel ◽

Tissue Transglutaminase ◽

Immunoglobulin A ◽

Collagenous Colitis ◽

Lymphocytic Colitis ◽

Small Bowel Biopsy ◽

Major Antigen ◽

Immunofluorescent Technique ◽

Endomysium Antibody

Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

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