Experimental Carbon Dioxide Laser Brain Lesions and Intracranial Dynamics: Part 1

Neurosurgery ◽  
1985 ◽  
Vol 16 (1) ◽  
pp. 5-8
Author(s):  
Ernesto Tiznado ◽  
Hector E. James ◽  
Cecilia Kemper ◽  
James H. Wood
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Laser Energy ◽  
Venous Pressure ◽  
Systolic Arterial Pressure ◽  
Brain Lesions ◽  
Albino Rabbit ◽  
Gross Pathology ◽  
The Impact ◽  
Change In Mean

Abstract Experimental brain lesions were created in the left parietooccipital cortex of the albino rabbit through the intact dura mater with high radiating carbon dioxide laser energy (40-watt impacts of 0.5-second duration for a total of 4 seconds on a 12.5-mm surface). Behavior, intracranial pressure (ICP), systolic arterial pressure (SAP), central venous pressure (CVP), electroencephalography (EEG), and gross pathology were studied at 2, 6, and 24 hours after the insult at a constant PaCO2 (38-42 torr). Disruption of the blood-brain barrier (Evans blue extravasation) was uniformly seen extending from the impact crater into the surrounding white matter in all groups. The ICP was elevated in shamoperated animals at 2 hours after the impact, and it remained elevated at 6 and 24 hours. The EEG revealed severe slowing with high voltage waves in the insulted left hemisphere. There was no change in mean SAP or CVP when compared to the sham-operated group. In the dexamethasone-pretreated group, there was a reduction of ICP when compared to the untreated group at 24 hours after the insult (P<0.005), but no changes in the gross pathology were noted. (Neurosurgery 16:5–8, 1985)

Experimental Carbon Dioxide Laser Brain Lesions and Intracranial Dynamics: Part 2

Neurosurgery ◽  
1985 ◽  
Vol 16 (4) ◽  
pp. 454-457
Author(s):  
Ernesto G. Tiznado ◽  
Hector E. James ◽  
Susan Moore
Keyword(s):  
Carbon Dioxide ◽  
White Matter ◽  
Water Content ◽  
Gray Matter ◽  
Carbon Dioxide Laser ◽  
Brain Lesions ◽  
Brain Water Content ◽  
The Impact ◽  
The Brain ◽  
Brain Water

Abstract Experimental brain lesions were created over the left parietooccipital cortex of the albino rabbit through the intact dura mater with high radiating carbon dioxide laser energy (40-W impact, 0.5-second duration, for a total time of 4 seconds on a 12.5-mm surface). The brain water content was studied 2, 6, and 24 hours after the insult. Another two groups of animals received acute therapy with either dexamethasone (1 mg/kg) or furosemide (1 mg/kg). In all groups, Evans blue extravasation uniformly extended from the impact crater into the surrounding white matter. The brain water content in the gray matter was elevated from the control value by 2 hours after impact (P < 0.005) and remained elevated at 6 and 24 hours. The white matter brain water content did not increase until 6 hours after impact and remained elevated in the 24-hour group (P < 0.005). After dexamethasone treatment, there was a significant decrease of water in the gray matter (P < 0.01), but not in the white matter. With furosemide therapy, there was no reduction of gray or white matter brain water.

Experimental Carbon Dioxide Laser Brain Lesions and Intracranial Dynamics: Part 2

Neurosurgery ◽  
1985 ◽  
Vol 16 (4) ◽  
pp. 454-457 ◽  
Author(s):  
Ernesto G. Tiznado ◽  
Hector E. James ◽  
Susan Moore
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Brain Lesions

Experimental Carbon Dioxide Laser Brain Lesions and Intracranial Dynamics: Part 1

Neurosurgery ◽  
1985 ◽  
Vol 16 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Ernesto Tiznado ◽  
Hector E. James ◽  
Cecilia Kemper
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Brain Lesions

Modified ultrafiltration in paediatric cardiac surgery

Perfusion ◽  
1998 ◽  
Vol 13 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Lise Schlünzen ◽  
Jens Pedersen ◽  
Kirsten Hjortholm ◽  
Ole K Hansen ◽  
Emmy Ditlevsen
Keyword(s):  
Carbon Dioxide ◽  
Heart Rate ◽  
Cardiac Surgery ◽  
Venous Pressure ◽  
Systolic Arterial Pressure ◽  
Carbon Dioxide Tension ◽  
Arterial Oxygen ◽  
Technical Problems ◽  
Paediatric Cardiac Surgery ◽  
Before And After

The effect of modified ultrafiltration (MUF) after cardiopulmonary bypass for paediatric cardiac surgery was evaluated in 138 children with moderate to severe congenital heart disease. The median age was 0.4 years (0 days to 6.5 years), and the weight 5.3 kg (2.2-20 kg). The operation was discontinued in six cases, three because of technical problems and three because of unstable circulation. One-hundred-and-thirty-four patients were ultrafiltrated for a median of 12 min (2-27 min) with an ultrafiltrate of median 44 ml/kg (6-118 ml/kg). Haematocrit was significantly increased from 28% (20-39%) to 36% (26-51%) and systolic arterial pressure from 56 mmHg (30-85 mmHg) to 74.0 mmHg (32-118 mmHg). Furthermore arterial oxygenation was significantly increased from 30.8 kPa (4.8-70.4 kPa) to 34.1 kPa (4.9-80.6 kPa), and arterial carbon dioxide tension from 4.8 kPa (3.1-7.3 kPa) to 5.1 kPa (3.1-7.6 kPa). Heart rate was significantly reduced from 145 beats/min (92-201 beats/min) to 136 beats/min (88-200 beats/min). There were no significant differences in central venous pressure, left atrial pressure and base excess before and after MUF. MUF increases systolic blood pressure, haematocrit, arterial oxygen and carbon dioxide tension coming off bypass in paediatric cardiac surgery and reduces heart rate and postoperative fluid overload.

Experimental carbon dioxide laser brain lesions and intracranial dynamics

Neurosurgery ◽  
1987 ◽  
Vol 20 (2) ◽  
pp. 219???21 ◽  
Author(s):  
H E James ◽  
S Schneider ◽  
S Bhasin
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Brain Lesions

Experimental Carbon Dioxide Laser Brain Lesions and Intracranial Dynamics: Part 3

Neurosurgery ◽  
1987 ◽  
Vol 20 (2) ◽  
pp. 219-221 ◽  
Author(s):  
Hector E. James ◽  
Sylvia Schneider ◽  
Sunil Bhasin
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Brain Lesions
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