Two-Point Discrimination Predicts Pain Relief after Lower Limb Nerve Decompression for Painful Diabetic Peripheral Neuropathy

Background: Diabetes is one of the most prevalent chronic health conditions and diabetic neuropathy one of its most prevalent and debilitating complications. While there are treatments available for painful diabetic peripheral neuropathy (pDPN), their effectiveness is limited. Method: This retrospective, multi-center, real-world review assessed pain relief and functional improvements for consecutive patients with diabetic neuropathy aged ≥18 years of age who were permanently implanted with a high-frequency (10 kHz) spinal cord stimulation (SCS) device. Available data were extracted from a commercial database. Results: In total 89 patients consented to being included in the analysis. Sixty-one percent (54/89) of participants were male and the average age was 64.4 years (SD = 9.1). Most patients (78.7%, 70/89) identified pain primarily in their feet or legs bilaterally. At the last assessment, 79.5% (58/73) of patients were treatment responders, defined as having at least 50% patient-reported pain relief from baseline. The average time of follow-up was 21.8 months (range: 4.3 to 46.3 months). A majority of patients reported improvements in sleep and overall function relative to their baseline. Conclusions: This real-world study in typical clinical practices found 10 kHz SCS provided meaningful pain relief for a substantial proportion of patients refractory to current pDPN management, similar to published literature. This patient population has tremendous unmet needs and this study helps demonstrate the potential for 10 kHz SCS to provide an alternative pain management approach.

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Relationship Between Pain Relief and Improvements in Patient Function/Quality of Life in Patients With Painful Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Treated With Pregabalin

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.03.008 ◽

2013 ◽

Vol 35 (5) ◽

pp. 612-623 ◽

Cited By ~ 34

Author(s):

Aaron Vinik ◽

Birol Emir ◽

Raymond Cheung ◽

Ed Whalen

Keyword(s):

Quality Of Life ◽

Peripheral Neuropathy ◽

Pain Relief ◽

Postherpetic Neuralgia ◽

Diabetic Peripheral Neuropathy ◽

Painful Diabetic Peripheral Neuropathy

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Capsaicin 8% Patch for Alternative Therapy of Painful Diabetic Peripheral Neuropathy

WMJ (Warmadewa Medical Journal) ◽

10.22225/wmj.6.2.3582.46-56 ◽

2021 ◽

Vol 6 (2) ◽

pp. 46-56

Author(s):

Muhammad Luthfi Adnan

Keyword(s):

Peripheral Neuropathy ◽

Pain Relief ◽

Full Text ◽

Diabetic Peripheral Neuropathy ◽

English Language ◽

Pain Treatment ◽

Meta Analysis ◽

Alternative Therapy ◽

Inclusion Criteria ◽

Painful Diabetic Peripheral Neuropathy

Abstract Diabetes is one of the most common health problems due to its high incidence and complications. One of the complications associated with diabetes is painful diabetic peripheral neuropathy (PDPN). The capsaicin 8% patch is a localized pain treatment that provides effective pain relief from a single application in patients with peripheral neuropathic pain. The aim of this review is to discuss the effect of capsaicin patch 8% in patients with painful diabetic peripheral neuropathy. The search strategy was conducted in PubMed and modified for other databases. The search was limited to English-language reports. The keywords used were "capsaicin”, "capsaicin patch", "painful diabetic peripheral neuropathy", and "pain management". The inclusion criteria used were randomized controlled trials (RCTs), clinical trials or another interventional analysis with full text in English with publications less than the last 10 years. The exclusion criteria used were a review, systematic review, or meta-analysis, studies that were not conducted in humans and non-full text in English with publications over the last 10 years. Results: There are 2 full-text that meet inclusion criteria. From articles related to studies that have been conducted, the use of capsaicin 8% patch can reduce pain, improve nerve function and quality of life in PDPN patients. The use of capsaicin 8% patch has the advantage to pain relief for patients with painful diabetic peripheral neuropathy. Keywords: Alternative therapy, Capsaicin 8% Patch, Diabetes complications, Pain Relief, Painful Diabetic Peripheral Neuropathy, topical drugs

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