High Glucose Concentration Favors the Selective Secretion of Islet Amyloid Polypeptide Through a Constitutive Secretory Pathway in Human Pancreatic Islets

Pancreas ◽  
2001 ◽  
Vol 22 (3) ◽  
pp. 307-310 ◽  
Author(s):  
R. Gasa ◽  
R. Gomis ◽  
R. Casamitjana ◽  
A. Novials
Keyword(s):  
Pancreatic Islets ◽  
High Glucose ◽  
Glucose Concentration ◽  
Secretory Pathway ◽  
Islet Amyloid Polypeptide ◽  
High Glucose Concentration ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Regulation of Islet Amyloid Polypeptide in Human Pancreatic Islets

Diabetes ◽  
1993 ◽  
Vol 42 (10) ◽  
pp. 1514-1519 ◽  
Author(s):  
A. Novials ◽  
Y. Sarri ◽  
R. Casamitjana ◽  
F. Rivera ◽  
R. Gomis
Keyword(s):  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Regulation of islet amyloid polypeptide in human pancreatic islets

Diabetes ◽  
1993 ◽  
Vol 42 (10) ◽  
pp. 1514-1519 ◽  
Author(s):  
A. Novials ◽  
Y. Sarri ◽  
R. Casamitjana ◽  
F. Rivera ◽  
R. Gomis
Keyword(s):  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Glucose induces an acute increase of superoxide dismutase activity in incubated rat pancreatic islets

1999 ◽  
Vol 276 (2) ◽  
pp. C507-C510 ◽  
Author(s):  
Henriette R. Oliveira ◽  
Rui Curi ◽  
Angelo R. Carpinelli
Keyword(s):  
Superoxide Dismutase ◽  
Pancreatic Islets ◽  
High Glucose ◽  
Glucose Concentration ◽  
Pentose Phosphate ◽  
High Glucose Concentration ◽  
Sod Activity ◽  
High Potassium ◽  
Rat Pancreatic Islets ◽  
Short Period

The activity of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSP) in isolated rat pancreatic islets exposed to high glucose concentration for a short period of time (60 min) was determined. High glucose concentration (16.7 mM) did not significantly alter catalase activity. GSP activity was increased by glucose at 5.6 mM, remaining elevated at higher concentrations up to 16.7 mM. However, the activity of SOD increased with glucose concentration, and this increment was closely correlated with the rate of insulin secretion ( r = 0.96). High potassium (30 mM) did not increase SOD activity, suggesting that the increase in intracellular ionic calcium concentration does not stimulate this enzyme activity. α-Ketoisocaproic acid and pyruvate, which are metabolized through the TCA cycle, did not increase SOD activity, indicating that the stimulation of SOD activity might be triggered by a factor produced through glycolysis or the pentose phosphate pathway.

scholarly journals Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

Diabetologia ◽  
1989 ◽  
Vol 32 (4) ◽  
pp. 240-244 ◽  
Author(s):  
A. Lukinius ◽  
E. Wilander ◽  
G. T. Westermark ◽  
U. Engstr�m ◽  
P. Westermark
Keyword(s):  
B Cell ◽  
Pancreatic Islets ◽  
Secretory Granules ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets

Metabolism and β-cell function of rat pancreatic islets exposed to human interleukin-1β in the presence of a high glucose concentration

1990 ◽  
Vol 26 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Stellan Sandler ◽  
Klaus Bendtzen ◽  
Décio L. Eizirik ◽  
Eva Strandell ◽  
Michael Welsh ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
High Glucose ◽  
Glucose Concentration ◽  
Cell Function ◽  
Interleukin 1Β ◽  
High Glucose Concentration ◽  
Β Cell ◽  
Rat Pancreatic Islets ◽  
Β Cell Function

scholarly journals Islet amyloid polypeptide: demonstration of mRNA in human pancreatic islets by in situ hybridization in islets with and without amyloid deposits

Diabetologia ◽  
1993 ◽  
Vol 36 (4) ◽  
pp. 323-328 ◽  
Author(s):  
G. T. Westermark ◽  
L. Christmanson ◽  
G. Terenghi ◽  
J. Permerth ◽  
C. Betsholtz ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Pancreatic Islets ◽  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Human Pancreatic Islets ◽  
Amyloid Deposits
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