Primary Colon Cancer Without Gross Mucosal Tumor: Unusual Presentation of a Common Malignancy

1998 ◽  
Vol 91 (12) ◽  
pp. 1173-1176 ◽  
Author(s):  
ALAN P. WIMMER ◽  
JOHN P. BOUFFARD ◽  
PATRICK R. STORMS ◽  
JOHN A. PILCHER ◽  
CHANG Y. LIANG ◽  
...  
2015 ◽  
Vol 4 (4) ◽  
pp. 157-166 ◽  
Author(s):  
Paul H Sugarbaker ◽  
Paolo Sammartino ◽  
Antonios-Apostolos Tentes

2021 ◽  
pp. 41-46
Author(s):  
Anum Aqsa ◽  
Sami Droubi ◽  
Shivantha Amarnath ◽  
Fady Haddad ◽  
Liliane Deeb

Metastasis to the colon from another primary internal malignancy is an untypical and a seldom reported entity. Direct visualization during colonoscopy is considered the gold standard of diagnosis. Pathologic diagnosis with immunohistochemical staining is essential to differentiate primary colorectal malignancy from secondary metastasis to the colon. We, hereby, present a case of a 53-year-old female status-post resection of left-sided papillary serous ovarian neoplasm who presented 2 years later with a single rectosigmoid intraluminal ulcerative mass imitating a primary colon cancer. Biopsies of the mass were consistent with metastasis from her primary ovarian carcinoma. We believe this case is unique because of the rarity of ovarian cancer metastasizing to the colon intraluminally rather than through direct locoregional invasion. Furthermore, it highlights the importance of considering secondary metastasis in patients with previous history of another primary internal malignancy.


2005 ◽  
Vol 30 (4) ◽  
pp. 286-288
Author(s):  
Venanzio Valenza ◽  
Daniela Di Giuda ◽  
Germano Perotti ◽  
Arnaldo Carbone

2005 ◽  
Vol 66 (2) ◽  
pp. 86-87
Author(s):  
Keizo Yoneda ◽  
Keiji Suzuki ◽  
Kenji Katumata ◽  
Tatehiko Wada ◽  
Fumiaki Katou ◽  
...  

2021 ◽  
Vol 11 ◽  
Author(s):  
Yansong Xu ◽  
Yi Chen ◽  
Chenyan Long ◽  
Huage Zhong ◽  
Fangfang Liang ◽  
...  

BackgroundLymph node metastasis (LNM) is a well-established prognostic factor for colon cancer. Preoperative LNM evaluation is relevant for planning colon cancer treatment. The aim of this study was to construct and evaluate a nomogram for predicting LNM in primary colon cancer according to pathological features.Patients and MethodsSix-hundred patients with clinicopathologically confirmed colon cancer (481 cases in the training set and 119 cases in the validation set) were enrolled in the Affiliated Cancer Hospital of Guangxi Medical University from January 2010 to December 2019. The expression of molecular markers (p53 and β-catenin) was determined by immunohistochemistry. Multivariate logistic regression was used to screen out independent risk factors, and a nomogram was established. The accuracy and discriminability of the nomogram were evaluated by consistency index and calibration curve.ResultsUnivariate logistic analysis revealed that LNM in colon cancer is significantly correlated (P <0.05) with tumor size, grading, stage, preoperative carcinoembryonic antigen (CEA) level, and peripheral nerve infiltration (PNI). Multivariate logistic regression analysis confirmed that CEA, grading, and PNI were independent prognostic factors of LNM (P <0.05). The nomogram for predicting LNM risk showed acceptable consistency and calibration capability in the training and validation sets.ConclusionsPreoperative CEA level, grading, and PNI were independent risk factor for LNM. Based on the present parameters, the constructed prediction model of LNM has potential application value.


2009 ◽  
Vol 34 (9) ◽  
pp. 596-597 ◽  
Author(s):  
Linh Ho ◽  
Heidi Wassef ◽  
Robert Henderson ◽  
John Seto

2018 ◽  
Vol 61 (4) ◽  
pp. 454-460 ◽  
Author(s):  
Emma Rosander ◽  
Caroline Nordenvall ◽  
Annika Sjövall ◽  
Fredrik Hjern ◽  
Torbjörn Holm

2012 ◽  
Vol 6 ◽  
pp. CMO.S8194 ◽  
Author(s):  
J. Quidde ◽  
D. Arnold ◽  
A. Stein

Large randomized trials demonstrated a benefit of adjuvant chemotherapy after resection of the primary colon cancer. It improves overall survival and reduces the risk of death, by 5% in UICC (Union Internationale Contre le Cancer) stage II and approximately 15%–20% in stage III. Fluoropyrimidines have been the standard drugs for the treatment of colon cancer since large randomized controlled trials demonstrated their efficacy and safety in treating patients suffering from this disease. Capecitabine is an orally administered fluoropyrimidine, which is preferably activated in tumor tissue to the active moiety 5-fluorouracil (5FU) and is cytotoxic through inhibition of DNA synthesis. It has proven equivalent efficacy and tolerability despite a changed toxicity profile compared to 5FU with less myelosuppression but more hand-and-foot syndrome. Capecitabine is well tolerated in elderly patients. The oral route of administration avoids frequent clinical visits as well as insertion of central venous catheters. The impact of the particular drug features on daily clinical practice is discussed in this review.


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