Diffuse Peritoneal Metastases From Primary Colon Cancer Demonstrated by Tc-99m-Labeled Red Blood Cell Scintigraphy

Metastasis to the colon from another primary internal malignancy is an untypical and a seldom reported entity. Direct visualization during colonoscopy is considered the gold standard of diagnosis. Pathologic diagnosis with immunohistochemical staining is essential to differentiate primary colorectal malignancy from secondary metastasis to the colon. We, hereby, present a case of a 53-year-old female status-post resection of left-sided papillary serous ovarian neoplasm who presented 2 years later with a single rectosigmoid intraluminal ulcerative mass imitating a primary colon cancer. Biopsies of the mass were consistent with metastasis from her primary ovarian carcinoma. We believe this case is unique because of the rarity of ovarian cancer metastasizing to the colon intraluminally rather than through direct locoregional invasion. Furthermore, it highlights the importance of considering secondary metastasis in patients with previous history of another primary internal malignancy.

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Primary Colon Cancer Without Gross Mucosal Tumor: Unusual Presentation of a Common Malignancy

Southern Medical Journal ◽

10.1097/00007611-199812000-00017 ◽

1998 ◽

Vol 91 (12) ◽

pp. 1173-1176 ◽

Cited By ~ 3

Author(s):

ALAN P. WIMMER ◽

JOHN P. BOUFFARD ◽

PATRICK R. STORMS ◽

JOHN A. PILCHER ◽

CHANG Y. LIANG ◽

...

Keyword(s):

Colon Cancer ◽

Unusual Presentation ◽

Primary Colon Cancer ◽

Primary Colon ◽

Common Malignancy

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Colonic metastasis after stomach cancer surgery that mimicked primary colon cancer : Case report

Progress of Digestive Endoscopy ◽

10.11641/pde.66.2_86 ◽

2005 ◽

Vol 66 (2) ◽

pp. 86-87

Author(s):

Keizo Yoneda ◽

Keiji Suzuki ◽

Kenji Katumata ◽

Tatehiko Wada ◽

Fumiaki Katou ◽

...

Keyword(s):

Colon Cancer ◽

Case Report ◽

Stomach Cancer ◽

Cancer Surgery ◽

Cancer Case ◽

Colonic Metastasis ◽

Primary Colon Cancer ◽

Primary Colon

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Preoperative Predictors of Lymph Node Metastasis in Colon Cancer

Frontiers in Oncology ◽

10.3389/fonc.2021.667477 ◽

2021 ◽

Vol 11 ◽

Author(s):

Yansong Xu ◽

Yi Chen ◽

Chenyan Long ◽

Huage Zhong ◽

Fangfang Liang ◽

...

Keyword(s):

Colon Cancer ◽

Logistic Regression ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Multivariate Logistic Regression Analysis ◽

Multivariate Logistic Regression ◽

Node Metastasis ◽

Logistic Analysis ◽

Primary Colon Cancer ◽

Primary Colon

BackgroundLymph node metastasis (LNM) is a well-established prognostic factor for colon cancer. Preoperative LNM evaluation is relevant for planning colon cancer treatment. The aim of this study was to construct and evaluate a nomogram for predicting LNM in primary colon cancer according to pathological features.Patients and MethodsSix-hundred patients with clinicopathologically confirmed colon cancer (481 cases in the training set and 119 cases in the validation set) were enrolled in the Affiliated Cancer Hospital of Guangxi Medical University from January 2010 to December 2019. The expression of molecular markers (p53 and β-catenin) was determined by immunohistochemistry. Multivariate logistic regression was used to screen out independent risk factors, and a nomogram was established. The accuracy and discriminability of the nomogram were evaluated by consistency index and calibration curve.ResultsUnivariate logistic analysis revealed that LNM in colon cancer is significantly correlated (P <0.05) with tumor size, grading, stage, preoperative carcinoembryonic antigen (CEA) level, and peripheral nerve infiltration (PNI). Multivariate logistic regression analysis confirmed that CEA, grading, and PNI were independent prognostic factors of LNM (P <0.05). The nomogram for predicting LNM risk showed acceptable consistency and calibration capability in the training and validation sets.ConclusionsPreoperative CEA level, grading, and PNI were independent risk factor for LNM. Based on the present parameters, the constructed prediction model of LNM has potential application value.

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Revised management of advanced primary colon cancer: Case series of 2 patients

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2019.01.046 ◽

2019 ◽

Vol 55 ◽

pp. 233-238 ◽

Cited By ~ 1

Author(s):

Paul H. Sugarbaker ◽

Mohamed T. Hassanein

Keyword(s):

Colon Cancer ◽

Case Series ◽

Cancer Case ◽

Primary Colon Cancer ◽

Primary Colon

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Allogeneic Leukocyte-Reduced Red Blood Cell Transfusion Is Associated with Postoperative Infectious Complications and Cancer Recurrence after Colon Cancer Resection

Digestive Surgery ◽

10.1159/000498865 ◽

2019 ◽

Vol 37 (2) ◽

pp. 163-170 ◽

Cited By ~ 1

Author(s):

Andrew-Paul Deeb ◽

Christopher T. Aquina ◽

John R.T. Monson ◽

Neil Blumberg ◽

Adan Z. Becerra ◽

...

Keyword(s):

Colon Cancer ◽

Blood Cell ◽

Red Blood Cell ◽

Cancer Recurrence ◽

Infectious Complications ◽

Oncologic Outcomes ◽

Red Blood Cell Transfusion ◽

Elective Resection ◽

Increased Risk ◽

The Impact

Background/Aims: Transfusion rates in colon cancer surgery are traditionally very high. Allogeneic red blood cell (RBC) transfusions are reported to induce immunomodulation that contributes to infectious morbidity and adverse oncologic outcomes. In an effort to attenuate these effects, the study institution implemented a universal leukocyte reduction protocol. The purpose of this study was to examine the impact of leukocyte-reduced (LR) transfusions on postoperative infectious complications, recurrence-free survival, and overall survival (OS). Methods: In a retrospective study, patients with stage I–III adenocarcinoma of the colon from 2003 to 2010 who underwent elective resection were studied. The primary outcome measures were postoperative infectious complications and recurrence-free and OS in patients that received a transfusion. Bivariate and multivariable regression analyses were performed for each endpoint. Results: Of 294 patients, 66 (22%) received a LR RBC transfusion. After adjustment, transfusion of LR RBCs was found to be independently associated with increased infectious complications (OR 3.10, 95% CI 1.24–7.73), increased odds of cancer recurrence (hazard ratio [HR] 3.74, 95% CI 1.94–7.21), and reduced OS when ≥3 units were administered (HR 2.24, 95% CI 1.12–4.48). Conclusion: Transfusion of LR RBCs is associated with an increased risk of infectious complications and worsened survival after elective surgery for colon cancer, irrespective of leukocyte reduction.

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