Effect Of Troglitazone On Blood Insulin Levels After Pancreas Transplantation With Systemic Venous Drainage In Rats

The effect of two experimental manipulations designed to mobilize lipids from adipose tissue have been investigated in rats with parasagittal knife cuts in the ventromedial hypothalamus (VMH). Those animals which displayed hyperphagia during the initial 5 days VMH knife cuts were then restricted in food intake to reduce body weights to levels comparable to that of the sham-operated controls. Two weeks following the knife-cut lesions, or sham operations, animals in the first experiment were exposed to the cold for 60 min, and those in the second experiment were injected with 2-deoxy-D-glucose (2-DG). The injections of 2-DG increased the level of glycerol in the control animals but not in the animals with VMH knife cuts. Both groups showed a rise in glucose. Plasma insulin and triglycerides were the same in both groups. Exposure to the cold increased the level of glycerol in both groups. The insulin levels were lower in the corresponding groups with knife cuts. These studies show that VMH knife cuts do not produce hyperinsulinemia in pair-gained rats.

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Portal and Systemic Venous Drainage in Pancreas and Kidney-Pancreas Transplantation: Early Surgical Complications and Outcomes

Transplantation Proceedings ◽

10.1016/j.transproceed.2009.06.046 ◽

2009 ◽

Vol 41 (6) ◽

pp. 2460-2462 ◽

Cited By ~ 12

Author(s):

J. Quintela ◽

J. Aguirrezabalaga ◽

A. Alonso ◽

C. Fernandez ◽

G. Corbal ◽

...

Keyword(s):

Surgical Complications ◽

Pancreas Transplantation ◽

Venous Drainage

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SIGNIFICANCE OF PORTAL VENOUS DRAINAGE AFTER WHOLE-ORGAN PANCREAS TRANSPLANTATION FOR ENDOCRINE GRAFT FUNCTION AND PREVENTION OF DIABETIC NEPHROPATHY

Transplantation Journal ◽

10.1097/00007890-199009000-00008 ◽

1990 ◽

Vol 50 (3) ◽

pp. 394-398 ◽

Cited By ~ 11

Author(s):

R. LOCK ◽

J. KLEMPNAUER ◽

G. EHLERDING ◽

K. KÜHN

Keyword(s):

Diabetic Nephropathy ◽

Pancreas Transplantation ◽

Graft Function ◽

Venous Drainage

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Maternal diets with low healthy eating index or mediterranean diet adherence scores are associated with high cord-blood insulin levels and insulin resistance markers at birth

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2012.92 ◽

2012 ◽

Vol 66 (9) ◽

pp. 1008-1015 ◽

Cited By ~ 34

Author(s):

E Gesteiro ◽

B Rodríguez Bernal ◽

S Bastida ◽

F J Sánchez-Muniz

Keyword(s):

Insulin Resistance ◽

Cord Blood ◽

Mediterranean Diet ◽

Healthy Eating ◽

Healthy Eating Index ◽

Insulin Levels ◽

Blood Insulin ◽

Diet Adherence ◽

Mediterranean Diet Adherence ◽

Resistance Markers

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A reduction in blood insulin levels as a host endocrine response during tumor development

International Journal of Immunopharmacology ◽

10.1016/s0192-0561(00)00067-9 ◽

2000 ◽

Vol 22 (12) ◽

pp. 1113-1119 ◽

Cited By ~ 1

Author(s):

Hugo Oscar Besedovsky ◽

Sigurd Normann ◽

Martin Schardt ◽

Adriana del Rey

Keyword(s):

Tumor Development ◽

Endocrine Response ◽

Insulin Levels ◽

Blood Insulin

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IMPLICATIONS OF VENOUS DRAINAGE IN PANCREAS TRANSPLANTATION ALONE.

Transplantation Journal ◽

10.1097/00007890-200607152-01366 ◽

2006 ◽

Vol 82 (Suppl 2) ◽

pp. 528

Author(s):

&NA;

Keyword(s):

Pancreas Transplantation ◽

Venous Drainage

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Influence of maternal HbA1C on fetal insulin levels

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20170717 ◽

2017 ◽

Vol 4 (2) ◽

pp. 604

Author(s):

Yashoda H. T. ◽

Swetha B. ◽

Manasa G.

Keyword(s):

Cord Blood ◽

Gestational Age ◽

Maternal Diabetes ◽

Medical Complication ◽

Blood Collection ◽

Insulin Levels ◽

Blood Insulin ◽

Gestation Age ◽

Cord Blood Collection ◽

Hba1c Levels

Background: Gestational diabetes is the most common medical complication during pregnancy. The objective of this study was to study the effect of maternal HbA1C levels on fetal insulin levels.Methods: Study was conducted at KIMS. 57 babies born to eligible diabetic pregnant women aged between19 to 40 years with gestational age between 35 and 42 weeks were recruited. Multiple births, gestational age <34 weeks, steroids given within 24 hours before birth, delay of >20 minutes in cord blood collection, delay of >60 minutes before freezing of plasma were excluded. Maternal investigations (HbA1C) were collected from maternal records. Umbilical cord blood was collected immediately after delivery and insulin levels were measured.Results: In this study, mean cord blood insulin levels were 7.83±3.53 μU/ml, mother’s mean HbA1C levels were 6.47±1.26. Statistically significant association was found between maternal HbA1C levels and fetal insulin levels. (r 0.37; P 0.004).Conclusions: Increased cord blood insulin levels were found in infants of diabetic mothers at birth, more so in large for gestation age babies, suggesting inutero fetal programming and hence strict control of maternal diabetes is recommended to decrease long-term fetal effects.

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