Antagonism of meta-chlorophenylpiperazine-induced inhibition of exploratory activity in an emergence procedure, the open field test, in rats

1997 ◽  
Vol 8 (4) ◽  
pp. 353-363 ◽  
Author(s):  
T F Meert ◽  
W Melis ◽  
N Aerts ◽  
G Clincke
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Exploratory Activity

scholarly journals Behavioral and Brain Structural Changes in Kindled Rats Induced by Coriaria Lactone/Pentylenetetrazol

2021 ◽  
Vol 15 ◽  
Author(s):  
Shixu He ◽  
Xiangmiao Qiu ◽  
Jing Wang ◽  
Linghui Yang ◽  
Anjiao Peng ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Structural Changes ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Contextual Fear Conditioning ◽  
Support Vector ◽  
Control Group ◽  
Coriaria Lactone ◽  
Structural Brain

Epilepsy is a common chronic neurological disease that is characterized by spontaneous seizures. It is commonly comorbid with behavioral and mood disorders. No studies have yet examined the behavioral or structural brain changes associated with coriaria lactone (CL)-induced and pentylenetetrazol (PTZ)-induced kindlings. This study examined whether the increased seizure susceptibility induced by CL/PTZ is accompanied by behavioral impairments and aimed to identify associated structural brain changes. Kindling models were induced using CL and PTZ, with 10 rats in each group. After successful kindling, rats were subjected to brain structural imaging using T2-weighted imaging and underwent behavioral tests, namely, the open field test, water maze tasks, and contextual fear conditioning. Voxel-based morphometry was then used to identify possible brain structural changes associated with kindling and/or behaviors. Support-vector machine learning was also applied for the integrative analysis of behavioral changes and structural brain imaging. In the open field test, both the CL (P = 0.04) and PTZ groups (P = 0.002) spent more time in the central area than the control group. Only the PTZ group (50.29 ± 29.56 s) showed a freezing time that was significantly less than that of the control group (94.8 ± 41.04 s; P = 0.024, Tukey's HSD-corrected) in contextual fear conditioning, which is suggestive of impaired fear-associated learning ability. Furthermore, brain imaging analysis revealed that the gray matter volume (GMV) of the hippocampus changed in both the CL and PTZ groups when compared to control. The support-vector machine learning model indicated that the retrosplenial dysgranular and primary somatosensory cortices were associated with both of the mentioned kindling models. Furthermore, the support-vector regression model results indicated that kindling-associated GMV changes can be used to predict general exploratory activity in the open field test. In conclusion, this is the first study to report greater general exploratory activity in a CL-induced kindling model. Moreover, the general exploratory activity in the open field test can be predicted by the GMV of brain regions associated with kindling.

Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test

2015 ◽  
Vol 464 (1) ◽  
pp. 223-225 ◽  
Author(s):  
N. V. Sayapina ◽  
T. A. Batalova ◽  
V. V. Chaika ◽  
V. L. Kuznetsov ◽  
A. A. Sergievich ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Multi Walled Carbon Nanotubes ◽  
Anxiety Levels ◽  
Walled Carbon Nanotubes

The effect of S100B deficit in early ontogenesis on behavior of adult animals in the open field test

2018 ◽  
pp. 246-249
Author(s):  
А.В. Лобанов ◽  
Д.М. Давыдов ◽  
Н.А. Перепеченова ◽  
О.Л. Черкашина ◽  
Н.С. Карпова ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Early Ontogenesis ◽  
S100b Protein ◽  
Open Field Behavior ◽  
Female Mice ◽  
Behavior Characteristic

Ранее было выявлено, что недостаток белка S100B в раннем онтогенезе влияет на формирование поведенческого фенотипа у мышей в гнездовом периоде развития. В данном исследовании были изучены эффекты недостатка белка S100B, вызванного иммунизацией самок мышей, на поведение их потомства в возрасте 12 месяцев в тесте открытого поля. Было установлено увеличение двигательной и исследовательской активности у самок и снижение активности у самцов мышей, рожденных от иммунизированных животных, относительно нормы. Также отмечено исчезновение нормального полового диморфизма в поведении в тесте открытого поля, характерного для контрольных мышей ICR в возрасте 12 месяцев. Earlier it was shown that the shortage of S100B protein in early ontogenesis affected formation of the behavioral phenotype in mice during the nesting period of development. This study focused on effects of S100B protein deficiency induced by immunization of female mice on behavior of their offspring at the age of 12 months in the open field. The motor and exploratory activity of females was increased whereas the activity of males born from immunized animals was decreased compared to the control. Also, normal sexual dimorphism of the open field behavior characteristic of 12-month old control ICR mice was lost.

scholarly journals Toxicity and Neuropharmacological Effects of Elenine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eduardo Navarro ◽  
S. J. Alonso ◽  
R. Navarro
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chemical Structure ◽  
Open Field Test ◽  
Control Group ◽  
General Behaviour ◽  
Similar Chemical ◽  
Sedative Effects ◽  
Traction Test ◽  
Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

scholarly journals Participation ofGABAAChloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Juan Francisco Rodríguez-Landa ◽  
Rosa Isela García-Ríos ◽  
Jonathan Cueto-Escobedo ◽  
Blandina Bernal-Morales ◽  
Carlos M. Contreras
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chloride Channels ◽  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Acid Mixture ◽  
Plus Maze ◽  
Gaba Binding ◽  
Defensive Burying

Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μg%; C14:0, myristic acid, 6.9 μg%; C16:0, palmitic acid, 35.3 μg%; C16:1, palmitoleic acid, 16.4 μg%; C18:0, stearic acid, 8.5 μg%; C18:1cis, oleic acid, 18.4 μg%; C18:1trans, elaidic acid, 3.5 μg%; C18:2, linoleic acid, 10.1 μg%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement ofγ-aminobutyric acid-A (GABAA) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, threeGABAAreceptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg),GABAAbenzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitiveGABAAchloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. TheGABAAantagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects throughGABAAreceptor chloride channels.

Acute effects of ethanol on behavioral responses of male and female zebrafish in the open field test with the influence of a non-familiar object

2021 ◽  
pp. 104474
Author(s):  
Thiele P. Souza ◽  
Francini Franscescon ◽  
Flavia V. Stefanello ◽  
Talise E. Müller ◽  
Laura W. Santos ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Behavioral Responses ◽  
Familiar Object ◽  
Acute Effects ◽  
Male And Female ◽  
Female Zebrafish
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