The effect of S100B deficit in early ontogenesis on behavior of adult animals in the open field test

2018 ◽  
pp. 246-249
Author(s):  
А.В. Лобанов ◽  
Д.М. Давыдов ◽  
Н.А. Перепеченова ◽  
О.Л. Черкашина ◽  
Н.С. Карпова ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Early Ontogenesis ◽  
S100b Protein ◽  
Open Field Behavior ◽  
Female Mice ◽  
Behavior Characteristic

Ранее было выявлено, что недостаток белка S100B в раннем онтогенезе влияет на формирование поведенческого фенотипа у мышей в гнездовом периоде развития. В данном исследовании были изучены эффекты недостатка белка S100B, вызванного иммунизацией самок мышей, на поведение их потомства в возрасте 12 месяцев в тесте открытого поля. Было установлено увеличение двигательной и исследовательской активности у самок и снижение активности у самцов мышей, рожденных от иммунизированных животных, относительно нормы. Также отмечено исчезновение нормального полового диморфизма в поведении в тесте открытого поля, характерного для контрольных мышей ICR в возрасте 12 месяцев. Earlier it was shown that the shortage of S100B protein in early ontogenesis affected formation of the behavioral phenotype in mice during the nesting period of development. This study focused on effects of S100B protein deficiency induced by immunization of female mice on behavior of their offspring at the age of 12 months in the open field. The motor and exploratory activity of females was increased whereas the activity of males born from immunized animals was decreased compared to the control. Also, normal sexual dimorphism of the open field behavior characteristic of 12-month old control ICR mice was lost.

Effect of DDT or Parathion on Open-Field Behavior of Offspring from DDT- or Parathion-Treated Mothers

1968 ◽  
Vol 22 (3_suppl) ◽  
pp. 1193-1196 ◽  
Author(s):  
Ghazi M. Al-Hachim ◽  
Gregory B. Fink
Keyword(s):  
Open Field ◽  
Field Test ◽  
Corn Oil ◽  
Open Field Test ◽  
Open Field Behavior ◽  
Field Behavior

Mice offspring were prepared and raised from DDT-, Parathion-, or corn oil-treated mothers during the first, second, and third trimesters of pregnancy. All Ss were subjected to the open-field test when 60 to 66 days old. The offspring of DDT- and Parathion-treated mothers did not behave differently from the offspring of corn oil-treated mothers (control).

scholarly journals Behavioral and Brain Structural Changes in Kindled Rats Induced by Coriaria Lactone/Pentylenetetrazol

2021 ◽  
Vol 15 ◽  
Author(s):  
Shixu He ◽  
Xiangmiao Qiu ◽  
Jing Wang ◽  
Linghui Yang ◽  
Anjiao Peng ◽  
...  
Keyword(s):  
Open Field ◽  
Field Test ◽  
Structural Changes ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Contextual Fear Conditioning ◽  
Support Vector ◽  
Control Group ◽  
Coriaria Lactone ◽  
Structural Brain

Epilepsy is a common chronic neurological disease that is characterized by spontaneous seizures. It is commonly comorbid with behavioral and mood disorders. No studies have yet examined the behavioral or structural brain changes associated with coriaria lactone (CL)-induced and pentylenetetrazol (PTZ)-induced kindlings. This study examined whether the increased seizure susceptibility induced by CL/PTZ is accompanied by behavioral impairments and aimed to identify associated structural brain changes. Kindling models were induced using CL and PTZ, with 10 rats in each group. After successful kindling, rats were subjected to brain structural imaging using T2-weighted imaging and underwent behavioral tests, namely, the open field test, water maze tasks, and contextual fear conditioning. Voxel-based morphometry was then used to identify possible brain structural changes associated with kindling and/or behaviors. Support-vector machine learning was also applied for the integrative analysis of behavioral changes and structural brain imaging. In the open field test, both the CL (P = 0.04) and PTZ groups (P = 0.002) spent more time in the central area than the control group. Only the PTZ group (50.29 ± 29.56 s) showed a freezing time that was significantly less than that of the control group (94.8 ± 41.04 s; P = 0.024, Tukey's HSD-corrected) in contextual fear conditioning, which is suggestive of impaired fear-associated learning ability. Furthermore, brain imaging analysis revealed that the gray matter volume (GMV) of the hippocampus changed in both the CL and PTZ groups when compared to control. The support-vector machine learning model indicated that the retrosplenial dysgranular and primary somatosensory cortices were associated with both of the mentioned kindling models. Furthermore, the support-vector regression model results indicated that kindling-associated GMV changes can be used to predict general exploratory activity in the open field test. In conclusion, this is the first study to report greater general exploratory activity in a CL-induced kindling model. Moreover, the general exploratory activity in the open field test can be predicted by the GMV of brain regions associated with kindling.

Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test

2015 ◽  
Vol 464 (1) ◽  
pp. 223-225 ◽  
Author(s):  
N. V. Sayapina ◽  
T. A. Batalova ◽  
V. V. Chaika ◽  
V. L. Kuznetsov ◽  
A. A. Sergievich ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Open Field ◽  
Field Test ◽  
Open Field Test ◽  
Exploratory Activity ◽  
Multi Walled Carbon Nanotubes ◽  
Anxiety Levels ◽  
Walled Carbon Nanotubes

scholarly journals GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice

2013 ◽  
Vol 4 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Divya Anchan ◽  
Sara Clark ◽  
Kevin Pollard ◽  
Nandini Vasudevan
Keyword(s):  
Open Field ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Female Mice ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

scholarly journals Thigmotaxis in a virtual human open field test

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel Gromer ◽  
Dominik P. Kiser ◽  
Paul Pauli
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Open Field ◽  
Field Test ◽  
Animal Studies ◽  
Open Field Test ◽  
Outer Region ◽  
Open Field Behavior ◽  
Behavioral Operations ◽  
Behavioral Parameters

AbstractAnimal models are used to study neurobiological mechanisms in mental disorders. Although there has been significant progress in the understanding of neurobiological underpinnings of threat-related behaviors and anxiety, little progress was made with regard to new or improved treatments for mental disorders. A possible reason for this lack of success is the unknown predictive and cross-species translational validity of animal models used in preclinical studies. Re-translational approaches, therefore, seek to establish cross-species translational validity by identifying behavioral operations shared across species. To this end, we implemented a human open field test in virtual reality and measured behavioral indices derived from animal studies in three experiments ($$\textit{N}=31$$ N = 31 , $$\textit{N}=30$$ N = 30 , and $$\textit{N}=80$$ N = 80 ). In addition, we investigated the associations between anxious traits and such behaviors. Results indicated a strong similarity in behavior across species, i.e., participants in our study—like rodents in animal studies—preferred to stay in the outer region of the open field, as indexed by multiple behavioral parameters. However, correlational analyses did not clearly indicate that these behaviors were a function of anxious traits of participants. We conclude that the realized virtual open field test is able to elicit thigmotaxis and thus demonstrates cross-species validity of this aspect of the test. Modulatory effects of anxiety on human open field behavior should be examined further by incorporating possible threats in the virtual scenario and/or by examining participants with higher anxiety levels or anxiety disorder patients.

scholarly journals Toxicity and Neuropharmacological Effects of Elenine

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eduardo Navarro ◽  
S. J. Alonso ◽  
R. Navarro
Keyword(s):  
Open Field ◽  
Field Test ◽  
Chemical Structure ◽  
Open Field Test ◽  
Control Group ◽  
General Behaviour ◽  
Similar Chemical ◽  
Sedative Effects ◽  
Traction Test ◽  
Central Depressant

Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived fromJusticia hyssopifolia. (Family: Acanthaceae). Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg. Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.

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