A55 CHRONIC ORAL ADMINISTRATION OF CALCIUM AND IRON TO ACCELERATE BODY LEAD DETOXIFICATION AFTER CHRONIC LEAD EXPOSURE IN WISTAR RATS

Objective: The aim of this study was to characterise the resveratrol inclusion complex with β-cyclodextrin (RCD) and evaluate their toxicity in wistar rats.Methods: The RCD were prepared in ultra-turrax. For characterization of the RCD were used: Fourier transform infra-red Spectroscopy, Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC) and X-ray powder diffraction. The RCD and others 4 treatments were performed by the chronic oral administration in 35 rats during 60 ds. After the treatments they were euthanized and the serum blood were collected to analyzed some hemogram and biochemical parameters including aspartyl aminotransferase (AST); alanine aminotransferase (AST); phosphatase alkaline (ALP); total bilirubin (TB); direct bilirubin (DB); total protein (TP); total cholesterol (TC), triacylglycerol (TAG), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), calcium, iron and phosphate using fully automated biochemistry analyzer.Results: The characterization results indicated a successful formation of the RCD. All hematological parameters analysed were within the normal values in all the groups. Furthermore, the hemogram and biochemical parameters were significantly (P>0.05) similar to the control group.Conclusion: The daily oral administration during 60 d of RCD are not harmful on blood parameters of Wistar rats. Thus, RCD can be used safely for treatment of some metabolic diseases.

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Oral administration of soybean peptide Vglycin normalizes fasting glucose and restores impaired pancreatic function in Type 2 diabetic Wistar rats

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2014.04.010 ◽

2014 ◽

Vol 25 (9) ◽

pp. 954-963 ◽

Cited By ~ 7

Author(s):

Hua Jiang ◽

Jueping Feng ◽

Zhongxia Du ◽

Hui Zhen ◽

Mei Lin ◽

...

Keyword(s):

Oral Administration ◽

Wistar Rats ◽

Fasting Glucose ◽

Pancreatic Function ◽

Type 2 Diabetic

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Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502010000100010 ◽

2010 ◽

Vol 25 (1) ◽

pp. 37-42 ◽

Cited By ~ 4

Author(s):

Vinicius von Diemen ◽

Manoel Roberto Maciel Trindade

Keyword(s):

Weight Gain ◽

Oral Administration ◽

Wistar Rats ◽

Monosodium Glutamate ◽

The Other ◽

Control Group ◽

Pregnant Rats ◽

Dependent Relation ◽

Dose Dependent

PURPOSE: Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life. METHODS: Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period. RESULTS: Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p<0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p<0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21st day of life was lower in the G20 regarding the other two groups (p<0,01). The G20 had a NAL increase percentage from birth to the 21st day of life lower than the G10 and this lower than the GC (p<0,01). CONCLUSIONS: MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up.

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