Premedication with Ipratropium Bromide for Bronchoscopy Produces Subjective Discomfort without Significant Clinical Benefit

1998 ◽  
Vol 5 (3) ◽  
pp. 200-203
Author(s):  
Jeffrey B. Rubins ◽  
Carol Bofenkamp ◽  
Melynne Youngblood ◽  
JoAnne Billings ◽  
Alain Broccard
Keyword(s):  
Clinical Benefit ◽  
Ipratropium Bromide ◽  
Significant Clinical Benefit ◽  
Subjective Discomfort

scholarly journals Photochemical Rearrangement of a 6-Azasteroid Oxaziridine to a Novel 17β-Carbomethoxy-A-homo-B-seco-6-aza-3, 5-androstanedione

2019 ◽  
Vol 53 (3) ◽  
Author(s):  
Stephen Frye
Keyword(s):  
Clinical Benefit ◽  
Structure Activity Relationship ◽  
Ring System ◽  
Activity Relationship ◽  
Reaction Sequence ◽  
Human Type ◽  
Significant Clinical Benefit ◽  
Photochemical Rearrangement ◽  
Structure Activity

4- and 6-azasteroids have been shown to be potent inhibitors of human 5α-reductase and certain azasteroids have shown significant clinical benefit in the treatment of androgen-related disorders. In an effort to expand the diversity of steroidal heterocycles synthetically accessible for structure-activity relationship exploration, a novel reaction sequence was applied to the preparation of the 6-azasteroid framework. To this end, photolysis of the oxaziridine derived from 17β-carbomethoxy-3β-triisopropylsilyloxy-6-azaandrost-5-ene (1) yielded a novel 7, 5-steroidal ring system that was evaluated for inhibition of human type 1 and 2 5α-reductase.

scholarly journals Particle beam radiotherapy with a surgical spacer placement for advanced abdominal leiomyosarcoma results in a significant clinical benefit

2009 ◽  
Vol 101 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Takumi Fukumoto ◽  
Shohei Komatsu ◽  
Yuichi Hori ◽  
Masao Murakami ◽  
Yoshio Hishikawa ◽  
...  
Keyword(s):  
Clinical Benefit ◽  
Particle Beam ◽  
Significant Clinical Benefit

Essential hypertension—definition, epidemiology, and pathophysiology

2010 ◽  
pp. 3023-3039
Author(s):  
Bryan Williams
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Cardiovascular Risk ◽  
High Blood Pressure ◽  
Clinical Benefit ◽  
Lower Blood Pressure ◽  
Significant Clinical Benefit ◽  
Lower Blood ◽  
Absolute Cardiovascular Risk

‘Essential hypertension’ is high blood pressure for which there is no clearly defined aetiology. From a practical perspective, it is best defined as that level of blood pressure at which treatment to lower blood pressure results in significant clinical benefit—a level which will vary from patient to patient depending on their absolute cardiovascular risk....

Sign in / Sign up

Export Citation Format

Share Document